Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer＇s disease

Mice carrying mutant amyloid precursor protein and presenilin-1 genes （APP/PS1 double trans- genic mice） have frequently been used in studies of Alzheimer＇s disease; however, such studies have focused mainly on hippocampal and cortical changes. The severity of Alzheimer＇s disease is known to correla...

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Veröffentlicht in:	Neural regeneration research 2013-08, Vol.8 (24), p.2249-2255
Hauptverfasser:	Liu, Lihua, Luo, Saiping, Zeng, Leping, Wang, Weihong, Yuan, Liming, Jian, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alzheimer's disease Brain Cytokines Dementia Memory Morphology Pathology Proteins Quantitative analysis Rodents Studies Transgenic animals 淀粉样前体蛋白肾上腺素能蓝斑转基因小鼠酪氨酸羟化酶阳性神经元阿尔茨海默氏病阿尔茨海默氏症
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