Human umbilical cord mesenchymal stem cell- loaded amniotic membrane for the repair of radial nerve injuryFNx01
In this study, we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits, i.e., a relatively closed nerve regeneration chamber. After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was...
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| Veröffentlicht in: | Neural regeneration research 2013-12, Vol.8 (36), p.3441-3448 |
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| container_title | Neural regeneration research |
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| creator | Li, Zhi Qin, Hanjiao Feng, Zishan Liu, Wei Zhou, Ye Yang, Lifeng Zhao, Wei Li, Youjun |
| description | In this study, we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits, i.e., a relatively closed nerve regeneration chamber. After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 × 10 7 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury. |
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After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 × 10 7 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><language>eng</language><publisher>Mumbai: Medknow Publications and Media Pvt. Ltd</publisher><subject>Amnion ; Amniotic sac ; Analysis ; Brachial plexus ; Care and treatment ; Cell adhesion & migration ; Cells ; Collagen ; Heparan sulfate ; Methods ; Spinal cord ; Stem cells ; Tissue engineering ; Transplantation ; Transplants & implants ; Umbilical cord</subject><ispartof>Neural regeneration research, 2013-12, Vol.8 (36), p.3441-3448</ispartof><rights>COPYRIGHT 2013 Medknow Publications and Media Pvt. Ltd.</rights><rights>2013. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). 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These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.</description><subject>Amnion</subject><subject>Amniotic sac</subject><subject>Analysis</subject><subject>Brachial plexus</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Cells</subject><subject>Collagen</subject><subject>Heparan sulfate</subject><subject>Methods</subject><subject>Spinal cord</subject><subject>Stem cells</subject><subject>Tissue engineering</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Umbilical cord</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptjVFLwzAQx4soOKffIeBzJW2aJn0cwzlB9GXv5ZJctowmmWkr7tsbUNAHuYe7-_H7310Ui0qKthQdl5d5bgUrORPNdXEzjkdKuexqtijidvYQyOyVG5yGgeiYDPE4YtCHs89gnNATjcNQkiGCQUPABxcnp7PmVYKAxMZEpgOShCdwiURLEhiXwwHTBxIXjnM6b14_aXVbXFkYRrz76ctit3ncrbfly9vT83r1Uu47TssOK6HQUuRWgqpo0zXWQM2hAtUyCdA0GVSqRcYZFUZiXqnqqAYqmGnYsrj_PntK8X3GceqPcU4hf-xrJmshKZX019rDgL0LNk4JtHej7ldMMi4op122Hv6xchn0TseA1mX-J_AF4vpysg</recordid><startdate>20131225</startdate><enddate>20131225</enddate><creator>Li, Zhi</creator><creator>Qin, Hanjiao</creator><creator>Feng, Zishan</creator><creator>Liu, Wei</creator><creator>Zhou, Ye</creator><creator>Yang, Lifeng</creator><creator>Zhao, Wei</creator><creator>Li, Youjun</creator><general>Medknow Publications and Media Pvt. 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After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 × 10 7 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.</abstract><cop>Mumbai</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neural regeneration research, 2013-12, Vol.8 (36), p.3441-3448 |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access |
| subjects | Amnion Amniotic sac Analysis Brachial plexus Care and treatment Cell adhesion & migration Cells Collagen Heparan sulfate Methods Spinal cord Stem cells Tissue engineering Transplantation Transplants & implants Umbilical cord |
| title | Human umbilical cord mesenchymal stem cell- loaded amniotic membrane for the repair of radial nerve injuryFNx01 |
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