APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer＇s disease
Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive declin...
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| Veröffentlicht in: | Neural regeneration research 2014-03, Vol.9 (6), p.653-660 |
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| creator | Zhou, Qin Peng, Dantao Yuan, Xinrui Lv, Zeping Pang, Shenghang Jiang, Wenyu Yang, Chuyu Shi, Xiaohong Pang, Guofang Yang, Yige Xie, Haiqun Zhang, Wandong Hu, Caiyou Yang, Ze |
| description | Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease. |
| doi_str_mv | 10.4103/1673-5374.130117 |
| format | Article |
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However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.4103/1673-5374.130117</identifier><language>eng</language><publisher>Mumbai: Medknow Publications & Media Pvt. Ltd</publisher><subject>Alzheimer's disease ; Apolipoproteins ; Cognitive ability ; Dementia ; Deoxyribonucleic acid ; Disease ; DNA ; Genes ; Low density lipoprotein receptors ; Patients ; Proteins ; Thermal cycling ; 中国汉族 ; 基因多态性 ; 患者 ; 认知功能障碍 ; 载脂蛋白E ; 迟发性 ; 阿尔茨海默氏病 ; 阿尔茨海默病</subject><ispartof>Neural regeneration research, 2014-03, Vol.9 (6), p.653-660</ispartof><rights>2014. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1847-11feaf416c92a7c4b9dcd45921296caf1dcee450ba88081472eb612a0d20be5f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Zhou, Qin</creatorcontrib><creatorcontrib>Peng, Dantao</creatorcontrib><creatorcontrib>Yuan, Xinrui</creatorcontrib><creatorcontrib>Lv, Zeping</creatorcontrib><creatorcontrib>Pang, Shenghang</creatorcontrib><creatorcontrib>Jiang, Wenyu</creatorcontrib><creatorcontrib>Yang, Chuyu</creatorcontrib><creatorcontrib>Shi, Xiaohong</creatorcontrib><creatorcontrib>Pang, Guofang</creatorcontrib><creatorcontrib>Yang, Yige</creatorcontrib><creatorcontrib>Xie, Haiqun</creatorcontrib><creatorcontrib>Zhang, Wandong</creatorcontrib><creatorcontrib>Hu, Caiyou</creatorcontrib><creatorcontrib>Yang, Ze</creatorcontrib><title>APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer＇s disease</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease.</description><subject>Alzheimer's disease</subject><subject>Apolipoproteins</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>Genes</subject><subject>Low density lipoprotein receptors</subject><subject>Patients</subject><subject>Proteins</subject><subject>Thermal cycling</subject><subject>中国汉族</subject><subject>基因多态性</subject><subject>患者</subject><subject>认知功能障碍</subject><subject>载脂蛋白E</subject><subject>迟发性</subject><subject>阿尔茨海默氏病</subject><subject>阿尔茨海默病</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo9kM1O3TAQhaOqSKXAnqUR64DHP3GyvLqiBQmJLtp15OtMEqMbO3hCK_oCbHkg3qmvgK8uZTVHmnPOjL6iOAV-oYDLS6iMLLU06gIkBzCfikOoTVWaRtefs_6__lJ8JbrnXNeNkIfFy-rH3RWzoWNZrIENGJDNcfs0xTSPniZiNiGzRNF5u2DH_vhlZC4OwS_-NzI_zdanCcPC5hSHhEQ-BuYDW48-IOU2u_i8pn1ym0vKGAgXttr-HdFPmP69PhPrPKElPC4OerslPHmfR8Wvb1c_19fl7d33m_XqtnRQK1MC9Gh7BZVrhDVObZrOdUo3AkRTOdtD5xCV5htb17wGZQRuKhCWd4JvUPfyqDjf9-avHx6RlvY-PqaQT7ZC1sJo3WiZXXzvcikSJezbOfnJpqcWeLvj3u7Atjuw7Z57jpy9R8YYhgcfho-MaqRSlVTyDVephBc</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Zhou, Qin</creator><creator>Peng, Dantao</creator><creator>Yuan, Xinrui</creator><creator>Lv, Zeping</creator><creator>Pang, Shenghang</creator><creator>Jiang, Wenyu</creator><creator>Yang, Chuyu</creator><creator>Shi, Xiaohong</creator><creator>Pang, Guofang</creator><creator>Yang, Yige</creator><creator>Xie, Haiqun</creator><creator>Zhang, Wandong</creator><creator>Hu, Caiyou</creator><creator>Yang, Ze</creator><general>Medknow Publications & Media Pvt. 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However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer＇s disease patients. We performed a 30-month longitudi- nal cohort study to investigate the relationship between Alzheimer＇s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer＇s disease were recruit- ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa- tients＇ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE 4 carriers compared with non-carriers. In addition, the APOE 4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive im- pairment progression group. In conclusion, APOE e4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ~4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer＇s disease.</abstract><cop>Mumbai</cop><pub>Medknow Publications & Media Pvt. Ltd</pub><doi>10.4103/1673-5374.130117</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access |
| subjects | Alzheimer's disease Apolipoproteins Cognitive ability Dementia Deoxyribonucleic acid Disease DNA Genes Low density lipoprotein receptors Patients Proteins Thermal cycling 中国汉族 基因多态性 患者 认知功能障碍 载脂蛋白E 迟发性 阿尔茨海默氏病 阿尔茨海默病 |
| title | APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer＇s disease |
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