Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease

Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson′s disease. In Parkinson′s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neural regeneration research 2014-10, Vol.9 (19), p.1708-1711
Hauptverfasser: Hegarty, ShaneV, O′Keeffe, GerardW, Sullivan, AideenM
Format: Artikel
Sprache:eng
Schlagworte:
Clinical trials
Parkinson's disease
Patients
Rodents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1711
container_issue 19
container_start_page 1708
container_title Neural regeneration research
container_volume 9
creator Hegarty, ShaneV
O′Keeffe, GerardW
Sullivan, AideenM
description Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson′s disease. In Parkinson′s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson′s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
doi_str_mv 10.4103/1673-5374.143410
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2382755354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2382755354</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1580-2560c30a9f12008c00e60b8cb5c647800b4d51bed08c8f100e4ea5b480cb92753</originalsourceid><addsrcrecordid>eNo1kMFKxDAQQIMouK7ePQY8d500SZt6k0VXYVEPeg5pOnW7dpuatII3v8lP8ktMWT1lyHvMwCPknMFCMOCXLMt5InkuFkzw-HNAZkzlWZIXUh3G-R8fk5MQtgBSFSmfEXzA0bvBu37TWFobOzgfrmjt3Y52E6rwA1vX77AbTEs9vo6tmRw6ONq5yOiwQW_6BgOtnadPxr81XXDdz9d3oFUT0AQ8JUe1aQOe_b1z8nJ787y8S9aPq_vl9TqxTCpIUpmB5WCKmqUAygJgBqWypbSZyBVAKSrJSqwiUzWLWKCRpVBgyyLNJZ-Ti_3e3rv3EcOgt270XTypU66iIbkU0YK9Zb0LwWOte9_sjP_UDPQUU0-19FRL72PyX9MxaT4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2382755354</pqid></control><display><type>article</type><title>Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease</title><source>Medknow Open Access Medical Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Journals@Ovid Complete</source><source>PubMed Central Open Access</source><creator>Hegarty, ShaneV ; O′Keeffe, GerardW ; Sullivan, AideenM</creator><creatorcontrib>Hegarty, ShaneV ; O′Keeffe, GerardW ; Sullivan, AideenM</creatorcontrib><description>Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson′s disease. In Parkinson′s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson′s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.4103/1673-5374.143410</identifier><language>eng</language><publisher>Mumbai: Medknow Publications &amp; Media Pvt. Ltd</publisher><subject>Clinical trials ; Parkinson's disease ; Patients ; Rodents</subject><ispartof>Neural regeneration research, 2014-10, Vol.9 (19), p.1708-1711</ispartof><rights>2014. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1580-2560c30a9f12008c00e60b8cb5c647800b4d51bed08c8f100e4ea5b480cb92753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Hegarty, ShaneV</creatorcontrib><creatorcontrib>O′Keeffe, GerardW</creatorcontrib><creatorcontrib>Sullivan, AideenM</creatorcontrib><title>Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease</title><title>Neural regeneration research</title><description>Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson′s disease. In Parkinson′s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson′s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.</description><subject>Clinical trials</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Rodents</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo1kMFKxDAQQIMouK7ePQY8d500SZt6k0VXYVEPeg5pOnW7dpuatII3v8lP8ktMWT1lyHvMwCPknMFCMOCXLMt5InkuFkzw-HNAZkzlWZIXUh3G-R8fk5MQtgBSFSmfEXzA0bvBu37TWFobOzgfrmjt3Y52E6rwA1vX77AbTEs9vo6tmRw6ONq5yOiwQW_6BgOtnadPxr81XXDdz9d3oFUT0AQ8JUe1aQOe_b1z8nJ787y8S9aPq_vl9TqxTCpIUpmB5WCKmqUAygJgBqWypbSZyBVAKSrJSqwiUzWLWKCRpVBgyyLNJZ-Ti_3e3rv3EcOgt270XTypU66iIbkU0YK9Zb0LwWOte9_sjP_UDPQUU0-19FRL72PyX9MxaT4</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Hegarty, ShaneV</creator><creator>O′Keeffe, GerardW</creator><creator>Sullivan, AideenM</creator><general>Medknow Publications &amp; Media Pvt. Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20141001</creationdate><title>Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease</title><author>Hegarty, ShaneV ; O′Keeffe, GerardW ; Sullivan, AideenM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1580-2560c30a9f12008c00e60b8cb5c647800b4d51bed08c8f100e4ea5b480cb92753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Clinical trials</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hegarty, ShaneV</creatorcontrib><creatorcontrib>O′Keeffe, GerardW</creatorcontrib><creatorcontrib>Sullivan, AideenM</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hegarty, ShaneV</au><au>O′Keeffe, GerardW</au><au>Sullivan, AideenM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease</atitle><jtitle>Neural regeneration research</jtitle><date>2014-10-01</date><risdate>2014</risdate><volume>9</volume><issue>19</issue><spage>1708</spage><epage>1711</epage><pages>1708-1711</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson′s disease. In Parkinson′s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson′s disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.</abstract><cop>Mumbai</cop><pub>Medknow Publications &amp; Media Pvt. Ltd</pub><doi>10.4103/1673-5374.143410</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1673-5374
ispartof Neural regeneration research, 2014-10, Vol.9 (19), p.1708-1711
issn 1673-5374
1876-7958
language eng
recordid cdi_proquest_journals_2382755354
source Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Journals@Ovid Complete; PubMed Central Open Access
subjects Clinical trials
Parkinson's disease
Patients
Rodents
title Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson′s disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A09%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neurotrophic%20factors:%20from%20neurodevelopmental%20regulators%20to%20novel%20therapies%20for%20Parkinson%E2%80%B2s%20disease&rft.jtitle=Neural%20regeneration%20research&rft.au=Hegarty,%20ShaneV&rft.date=2014-10-01&rft.volume=9&rft.issue=19&rft.spage=1708&rft.epage=1711&rft.pages=1708-1711&rft.issn=1673-5374&rft.eissn=1876-7958&rft_id=info:doi/10.4103/1673-5374.143410&rft_dat=%3Cproquest_cross%3E2382755354%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2382755354&rft_id=info:pmid/&rfr_iscdi=true