Light-assisted gadofullerene nanoparticles disrupt tumor vasculatures for potent melanoma treatment

The traditional photodynamic therapy (PDT) using a photosensitizer and oxygen under light generates reactive oxygen species (ROS) to kill tumor cells. However, its treatment efficiency is limited by insufficient oxygen in tumor cells. Herein, β-alanine modified gadofullerene nanoparticles (GFNPs) we...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-03, Vol.8 (12), p.258-2518
Hauptverfasser:	Lu, Zhigao, Jia, Wang, Deng, Ruijun, Zhou, Yue, Li, Xue, Yu, Tong, Zhen, Mingming, Wang, Chunru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Animals beta-Alanine - chemistry Cadherins Cell Death - drug effects Disruption Efficiency Endothelial cells Female Fullerenes - chemistry Fullerenes - pharmacology Hypoxemia Light Melanoma Melanoma - drug therapy Melanoma - pathology Mice Mice, Inbred BALB C Mice, Nude Nanoparticles Nanoparticles - chemistry Necrosis Oxygen Particle Size Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Porphyrins - chemistry Porphyrins - pharmacology Proteins Reactive oxygen species Singlet oxygen Singlet Oxygen - analysis Skin Neoplasms - drug therapy Skin Neoplasms - pathology Surface Properties Tumor cells Tumors
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