EFFICACY OF INTRAVENOUS KETOROLAC IN POST ELECTRO-CONVULSIVE THERAPY HEADACHE
ABSTRACT Objectives: To compare the mean headache score after single dose Intra-venous (I/V) ketorolac administered as part of General Anaesthesia (GA) following Electro-convulsive Therapy (ECT) versus placebo. Study Design: Randomized controlled trial. Place and Duration of Study: Psychiatry Depart...
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| Veröffentlicht in: | Pakistan Armed Forces medical journal 2020-02 (1), p.236 |
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| description | ABSTRACT Objectives: To compare the mean headache score after single dose Intra-venous (I/V) ketorolac administered as part of General Anaesthesia (GA) following Electro-convulsive Therapy (ECT) versus placebo. Study Design: Randomized controlled trial. Place and Duration of Study: Psychiatry Department, CMH Lahore, from Jun 2014 to Dec 2014. Methodology: 100 patients fulfilling the inclusion criteria were selected after permission from Hospital Ethical Committee and completion of informed written consent. Registration numbers, name, age and gender were noted. Patients were divided into two groups randomly by using random number table. In group A, Intravenous Ketorolac 0.5mg/kg body weight was given to all patients as part of medications administered at the time of ECT while in group B placebo (normal saline) was given. All patients were assessed 2 hrs after ECT for subjective experience of headache on Visual Analogue Scale (VAS). All the information was collected through well defined proforma. Results: Headache scores showed significant improvement after treatment with a p-value |
| format | Article |
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Study Design: Randomized controlled trial. Place and Duration of Study: Psychiatry Department, CMH Lahore, from Jun 2014 to Dec 2014. Methodology: 100 patients fulfilling the inclusion criteria were selected after permission from Hospital Ethical Committee and completion of informed written consent. Registration numbers, name, age and gender were noted. Patients were divided into two groups randomly by using random number table. In group A, Intravenous Ketorolac 0.5mg/kg body weight was given to all patients as part of medications administered at the time of ECT while in group B placebo (normal saline) was given. All patients were assessed 2 hrs after ECT for subjective experience of headache on Visual Analogue Scale (VAS). All the information was collected through well defined proforma. Results: Headache scores showed significant improvement after treatment with a p-value <0.001. Mean score in placebo group was 4.54 ± 2.83 whereas the mean headache score in ketorolac group was 2.48 ± 2.34. Single dose I/V ketorolac reduced 2.06 ± 0.52 score in headache compared to placebo group. There was a statistically significant decrease in headache score after treatment. Conclusion: Based on our results single dose I/V ketorolac is effective with respect to placebo in reducing postECT headache.</description><identifier>ISSN: 0030-9648</identifier><identifier>EISSN: 2411-8842</identifier><language>eng</language><publisher>Rawalpindi: Knowledge Bylanes</publisher><subject>Age ; Anesthesia ; Anti-inflammatory agents ; Depression (Mood disorder) ; Drug therapy ; Electroconvulsive therapy ; Eletriptan ; Gender ; Headaches ; Mental disorders ; Misinformation ; Nonsteroidal anti-inflammatory agents ; Pain ; Psychiatry ; Steroidal anti-inflammatory agents ; Studies ; Succinylcholine ; Suicidal behavior</subject><ispartof>Pakistan Armed Forces medical journal, 2020-02 (1), p.236</ispartof><rights>COPYRIGHT 2020 Knowledge Bylanes</rights><rights>(c)2020 Pakistan Armed Forces Medical Journal</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Umer, Muhammed</creatorcontrib><creatorcontrib>Farrukh Saleem Shah</creatorcontrib><creatorcontrib>Rahim, Sajid</creatorcontrib><title>EFFICACY OF INTRAVENOUS KETOROLAC IN POST ELECTRO-CONVULSIVE THERAPY HEADACHE</title><title>Pakistan Armed Forces medical journal</title><description>ABSTRACT Objectives: To compare the mean headache score after single dose Intra-venous (I/V) ketorolac administered as part of General Anaesthesia (GA) following Electro-convulsive Therapy (ECT) versus placebo. Study Design: Randomized controlled trial. Place and Duration of Study: Psychiatry Department, CMH Lahore, from Jun 2014 to Dec 2014. Methodology: 100 patients fulfilling the inclusion criteria were selected after permission from Hospital Ethical Committee and completion of informed written consent. Registration numbers, name, age and gender were noted. Patients were divided into two groups randomly by using random number table. In group A, Intravenous Ketorolac 0.5mg/kg body weight was given to all patients as part of medications administered at the time of ECT while in group B placebo (normal saline) was given. All patients were assessed 2 hrs after ECT for subjective experience of headache on Visual Analogue Scale (VAS). All the information was collected through well defined proforma. Results: Headache scores showed significant improvement after treatment with a p-value <0.001. Mean score in placebo group was 4.54 ± 2.83 whereas the mean headache score in ketorolac group was 2.48 ± 2.34. Single dose I/V ketorolac reduced 2.06 ± 0.52 score in headache compared to placebo group. There was a statistically significant decrease in headache score after treatment. Conclusion: Based on our results single dose I/V ketorolac is effective with respect to placebo in reducing postECT headache.</description><subject>Age</subject><subject>Anesthesia</subject><subject>Anti-inflammatory agents</subject><subject>Depression (Mood disorder)</subject><subject>Drug therapy</subject><subject>Electroconvulsive therapy</subject><subject>Eletriptan</subject><subject>Gender</subject><subject>Headaches</subject><subject>Mental disorders</subject><subject>Misinformation</subject><subject>Nonsteroidal anti-inflammatory agents</subject><subject>Pain</subject><subject>Psychiatry</subject><subject>Steroidal anti-inflammatory agents</subject><subject>Studies</subject><subject>Succinylcholine</subject><subject>Suicidal behavior</subject><issn>0030-9648</issn><issn>2411-8842</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptTVtLwzAYDaLgmPsPBZ8ruTd9DDG1w7qMrhvsqaRpOjq2Vdft_xtR0Ae_8_AdDudyAyaYIhQLQfEtmEBIYJxyKu7BbBz3MBwjmEI2AW86y-ZKqm1ksmi-qEq50QuzXkWvujKlKaQKarQ0qyrShVZVaWJlFpt1sZpvdFTlupTLbZRr-SxVrh_AXWcPo5_9_ClYZ7pSeVyYl7BSxDvE2SX2QnhsUdM02GGYYhoI4h1i1grRudbxlKQYURZYIxz3TZtwy2wnWsgTl5ApePzufT8PH1c_Xur9cD2fwmSNiUCM85TSX9fOHnzdn7rhcrbu2I-ulhwlKCEEfnU9_eMKaP2xd8PJd33Q_wQ-AaelX_A</recordid><startdate>20200229</startdate><enddate>20200229</enddate><creator>Umer, Muhammed</creator><creator>Farrukh Saleem Shah</creator><creator>Rahim, Sajid</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20200229</creationdate><title>EFFICACY OF INTRAVENOUS KETOROLAC IN POST ELECTRO-CONVULSIVE THERAPY HEADACHE</title><author>Umer, Muhammed ; Farrukh Saleem Shah ; Rahim, Sajid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g165t-e88e2a1bbb2c20924bb216f15aa88fcdc69392145dc6b8c6ebd76a5af8d067c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Anesthesia</topic><topic>Anti-inflammatory agents</topic><topic>Depression (Mood disorder)</topic><topic>Drug therapy</topic><topic>Electroconvulsive therapy</topic><topic>Eletriptan</topic><topic>Gender</topic><topic>Headaches</topic><topic>Mental disorders</topic><topic>Misinformation</topic><topic>Nonsteroidal anti-inflammatory agents</topic><topic>Pain</topic><topic>Psychiatry</topic><topic>Steroidal anti-inflammatory agents</topic><topic>Studies</topic><topic>Succinylcholine</topic><topic>Suicidal behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Umer, Muhammed</creatorcontrib><creatorcontrib>Farrukh Saleem Shah</creatorcontrib><creatorcontrib>Rahim, Sajid</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pakistan Armed Forces medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Umer, Muhammed</au><au>Farrukh Saleem Shah</au><au>Rahim, Sajid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFICACY OF INTRAVENOUS KETOROLAC IN POST ELECTRO-CONVULSIVE THERAPY HEADACHE</atitle><jtitle>Pakistan Armed Forces medical journal</jtitle><date>2020-02-29</date><risdate>2020</risdate><issue>1</issue><spage>236</spage><pages>236-</pages><issn>0030-9648</issn><eissn>2411-8842</eissn><abstract>ABSTRACT Objectives: To compare the mean headache score after single dose Intra-venous (I/V) ketorolac administered as part of General Anaesthesia (GA) following Electro-convulsive Therapy (ECT) versus placebo. Study Design: Randomized controlled trial. Place and Duration of Study: Psychiatry Department, CMH Lahore, from Jun 2014 to Dec 2014. Methodology: 100 patients fulfilling the inclusion criteria were selected after permission from Hospital Ethical Committee and completion of informed written consent. Registration numbers, name, age and gender were noted. Patients were divided into two groups randomly by using random number table. In group A, Intravenous Ketorolac 0.5mg/kg body weight was given to all patients as part of medications administered at the time of ECT while in group B placebo (normal saline) was given. All patients were assessed 2 hrs after ECT for subjective experience of headache on Visual Analogue Scale (VAS). All the information was collected through well defined proforma. Results: Headache scores showed significant improvement after treatment with a p-value <0.001. Mean score in placebo group was 4.54 ± 2.83 whereas the mean headache score in ketorolac group was 2.48 ± 2.34. Single dose I/V ketorolac reduced 2.06 ± 0.52 score in headache compared to placebo group. There was a statistically significant decrease in headache score after treatment. Conclusion: Based on our results single dose I/V ketorolac is effective with respect to placebo in reducing postECT headache.</abstract><cop>Rawalpindi</cop><pub>Knowledge Bylanes</pub><oa>free_for_read</oa></addata></record> |
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| subjects | Age Anesthesia Anti-inflammatory agents Depression (Mood disorder) Drug therapy Electroconvulsive therapy Eletriptan Gender Headaches Mental disorders Misinformation Nonsteroidal anti-inflammatory agents Pain Psychiatry Steroidal anti-inflammatory agents Studies Succinylcholine Suicidal behavior |
| title | EFFICACY OF INTRAVENOUS KETOROLAC IN POST ELECTRO-CONVULSIVE THERAPY HEADACHE |
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