Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin–dopamine antagonists against insomnia and nocturnal delirium

Torsade de pointes (TdP) occurred in a long QT syndrome type 3 (LQT3) patient after switching perospirone to blonanserin. We studied how their electropharmacological effects had induced TdP in the LQT3 patient. Perospirone hydrochloride ( n = 4) or blonanserin ( n = 4) of 0.01, 0.1, and 1 mg/kg, i...

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Veröffentlicht in:	Heart and vessels 2020-04, Vol.35 (4), p.593-602
Hauptverfasser:	Kambayashi, Ryuichi, Hagiwara-Nagasawa, Mihoko, Goto, Ai, Chiba, Koki, Izumi-Nakaseko, Hiroko, Naito, Atsuhiko T., Matsumoto, Akio, Sugiyama, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Anesthetics, Inhalation Animals Antagonists Biomedical Engineering and Bioengineering Blood pressure Calcium (intracellular) Calcium Channel Agonists - toxicity Calcium currents Calcium ions Cardiac Conduction System Disease - physiopathology Cardiac output Cardiac Surgery Cardiology Conduction Delirium - drug therapy Dogs Dopamine Dopamine Antagonists - toxicity Dosage Dose-Response Relationship, Drug Drug therapy Electrocardiography Female Halothane Heart Conduction System - drug effects Heart Conduction System - metabolism Heart Conduction System - physiopathology Heart rate Humans Hypotension Insomnia Isoindoles Long QT syndrome Long QT Syndrome - physiopathology Medicine Medicine & Public Health Mental disorders Middle Aged Models, Animal Muscle contraction Original Article Piperazines Piperidines Potassium Channel Blockers - toxicity Prolongation Serotonin Serotonin Antagonists - toxicity Sleep disorders Sleep Initiation and Maintenance Disorders - drug therapy Sympathetic nervous system Thiazoles Torsades de Pointes - chemically induced Torsades de Pointes - metabolism Torsades de Pointes - physiopathology Vascular Surgery
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