Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report
Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant m...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2020-03, Vol.476 (3), p.469-473 |
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| creator | Minami, Kazuhiro Jimbo, Naoe Tanaka, Yugo Hokka, Daisuke Miyamoto, Yoshifumi Itoh, Tomoo Maniwa, Yoshimasa |
| description | Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant mesothelioma in situ (MIS) has been gaining increasing attention with advances in genome-based methods including fluorescence in situ hybridization (FISH) as well as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male with a history of asbestos exposure presenting with massive pleural effusion in the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural biopsy of the right side revealed a single layer of atypical mesothelial cells without invasive lesions by hematoxylin and eosin staining. However, these mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry and homozygous deletion of
CDKN2A
(
p16
) by FISH, leading to the diagnosis of MIS. |
| doi_str_mv | 10.1007/s00428-019-02674-x |
| format | Article |
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CDKN2A
(
p16
) by FISH, leading to the diagnosis of MIS.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-019-02674-x</identifier><identifier>PMID: 31667596</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>5'-Methylthioadenosine phosphorylase ; Aged ; Asbestos ; Biomarkers, Tumor - analysis ; Biopsy ; Brief Report ; Case reports ; Clonal deletion ; Cyclin-Dependent Kinase Inhibitor p16 - analysis ; Cyclin-Dependent Kinase Inhibitor p16 - genetics ; Early Diagnosis ; Fluorescence ; Fluorescence in situ hybridization ; Gene deletion ; Genes, p16 ; Genomes ; Humans ; Immunohistochemistry ; Lung Neoplasms - diagnosis ; Male ; Medicine ; Medicine & Public Health ; Mesothelioma ; Mesothelioma - diagnosis ; Mesothelioma, Malignant ; Pathology ; Phosphorylase ; Phosphorylases ; Pleural effusion ; Pleural Neoplasms - diagnosis ; Purine-Nucleoside Phosphorylase - analysis ; Purine-Nucleoside Phosphorylase - biosynthesis ; Quality in Pathology ; Sequence Deletion ; Surgery ; Thorax</subject><ispartof>Virchows Archiv : an international journal of pathology, 2020-03, Vol.476 (3), p.469-473</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Virchows Archiv is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-b51a5498f8a9e4aec570bb53d6b002518611015ac4c8babe7e06a56805d5afc53</citedby><cites>FETCH-LOGICAL-c485t-b51a5498f8a9e4aec570bb53d6b002518611015ac4c8babe7e06a56805d5afc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-019-02674-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-019-02674-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31667596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minami, Kazuhiro</creatorcontrib><creatorcontrib>Jimbo, Naoe</creatorcontrib><creatorcontrib>Tanaka, Yugo</creatorcontrib><creatorcontrib>Hokka, Daisuke</creatorcontrib><creatorcontrib>Miyamoto, Yoshifumi</creatorcontrib><creatorcontrib>Itoh, Tomoo</creatorcontrib><creatorcontrib>Maniwa, Yoshimasa</creatorcontrib><title>Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant mesothelioma in situ (MIS) has been gaining increasing attention with advances in genome-based methods including fluorescence in situ hybridization (FISH) as well as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male with a history of asbestos exposure presenting with massive pleural effusion in the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural biopsy of the right side revealed a single layer of atypical mesothelial cells without invasive lesions by hematoxylin and eosin staining. However, these mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry and homozygous deletion of
CDKN2A
(
p16
) by FISH, leading to the diagnosis of MIS.</description><subject>5'-Methylthioadenosine phosphorylase</subject><subject>Aged</subject><subject>Asbestos</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy</subject><subject>Brief Report</subject><subject>Case reports</subject><subject>Clonal deletion</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - analysis</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - genetics</subject><subject>Early Diagnosis</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene deletion</subject><subject>Genes, p16</subject><subject>Genomes</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesothelioma</subject><subject>Mesothelioma - diagnosis</subject><subject>Mesothelioma, Malignant</subject><subject>Pathology</subject><subject>Phosphorylase</subject><subject>Phosphorylases</subject><subject>Pleural effusion</subject><subject>Pleural Neoplasms - diagnosis</subject><subject>Purine-Nucleoside Phosphorylase - analysis</subject><subject>Purine-Nucleoside Phosphorylase - biosynthesis</subject><subject>Quality in Pathology</subject><subject>Sequence 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Academic UKI Edition</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minami, Kazuhiro</au><au>Jimbo, Naoe</au><au>Tanaka, Yugo</au><au>Hokka, Daisuke</au><au>Miyamoto, Yoshifumi</au><au>Itoh, Tomoo</au><au>Maniwa, Yoshimasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>476</volume><issue>3</issue><spage>469</spage><epage>473</epage><pages>469-473</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant mesothelioma in situ (MIS) has been gaining increasing attention with advances in genome-based methods including fluorescence in situ hybridization (FISH) as well as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male with a history of asbestos exposure presenting with massive pleural effusion in the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural biopsy of the right side revealed a single layer of atypical mesothelial cells without invasive lesions by hematoxylin and eosin staining. However, these mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry and homozygous deletion of
CDKN2A
(
p16
) by FISH, leading to the diagnosis of MIS.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31667596</pmid><doi>10.1007/s00428-019-02674-x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2020-03, Vol.476 (3), p.469-473 |
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| subjects | 5'-Methylthioadenosine phosphorylase Aged Asbestos Biomarkers, Tumor - analysis Biopsy Brief Report Case reports Clonal deletion Cyclin-Dependent Kinase Inhibitor p16 - analysis Cyclin-Dependent Kinase Inhibitor p16 - genetics Early Diagnosis Fluorescence Fluorescence in situ hybridization Gene deletion Genes, p16 Genomes Humans Immunohistochemistry Lung Neoplasms - diagnosis Male Medicine Medicine & Public Health Mesothelioma Mesothelioma - diagnosis Mesothelioma, Malignant Pathology Phosphorylase Phosphorylases Pleural effusion Pleural Neoplasms - diagnosis Purine-Nucleoside Phosphorylase - analysis Purine-Nucleoside Phosphorylase - biosynthesis Quality in Pathology Sequence Deletion Surgery Thorax |
| title | Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report |
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