Permeability of Intestinal and Blood—Tissue Barriers in Rats for Evans Blue Dye under Conditions of Acute Intoxication with Cyclophosphamide
Myeloablative therapy was modeled by administration of cyclophosphamide to rats in a dose of 2.1 LD50 for 14 days. Under these conditions, increased accumulation of Evans blue dye given by gavage was observed in the blood, brain, lung, liver, kidney, and ileum (by 34, 1.6, 149, 46, 30, and 6.2 times...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2019-11, Vol.168 (1), p.38-40 |
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| description | Myeloablative therapy was modeled by administration of cyclophosphamide to rats in a dose of 2.1 LD50 for 14 days. Under these conditions, increased accumulation of Evans blue dye given by gavage was observed in the blood, brain, lung, liver, kidney, and ileum (by 34, 1.6, 149, 46, 30, and 6.2 times, respectively). After intravenous injection of the dye, its accumulation was increased only in the lung and ileum. Thus, simulation of myeloablation cytostatic therapy by cyclophosphamide injection to rats is associated with impairment of the intestinal and lung—blood barriers. These alterations predispose to penetration of biologically active substances from the small intestine, gastrointestinal chyme, and lungs to the blood, thus contributing to the development of the early toxic effects of cyclophosphamide. |
| doi_str_mv | 10.1007/s10517-019-04640-8 |
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V. ; Ivnitsky, Ju. Ju ; Rejniuk, V. L.</creator><creatorcontrib>Schäfer, T. V. ; Ivnitsky, Ju. Ju ; Rejniuk, V. L.</creatorcontrib><description>Myeloablative therapy was modeled by administration of cyclophosphamide to rats in a dose of 2.1 LD50 for 14 days. Under these conditions, increased accumulation of Evans blue dye given by gavage was observed in the blood, brain, lung, liver, kidney, and ileum (by 34, 1.6, 149, 46, 30, and 6.2 times, respectively). After intravenous injection of the dye, its accumulation was increased only in the lung and ileum. Thus, simulation of myeloablation cytostatic therapy by cyclophosphamide injection to rats is associated with impairment of the intestinal and lung—blood barriers. These alterations predispose to penetration of biologically active substances from the small intestine, gastrointestinal chyme, and lungs to the blood, thus contributing to the development of the early toxic effects of cyclophosphamide.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-019-04640-8</identifier><identifier>PMID: 31748869</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute intoxication ; Animals ; Biological activity ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Blood-Brain Barrier - drug effects ; Brain - drug effects ; Brain - metabolism ; Cell Biology ; Cyclophosphamide ; Cyclophosphamide - pharmacology ; Dyes ; Evans Blue - metabolism ; Ileum ; Injection ; Internal Medicine ; Intestines - drug effects ; Intoxication ; Intravenous administration ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Laboratory Medicine ; Liver ; Liver - drug effects ; Liver - metabolism ; Lung - drug effects ; Lung - metabolism ; Male ; Methylene blue ; Pathology ; Permeability ; Rats ; Small intestine</subject><ispartof>Bulletin of experimental biology and medicine, 2019-11, Vol.168 (1), p.38-40</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2019). 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Ju</creatorcontrib><creatorcontrib>Rejniuk, V. L.</creatorcontrib><title>Permeability of Intestinal and Blood—Tissue Barriers in Rats for Evans Blue Dye under Conditions of Acute Intoxication with Cyclophosphamide</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Myeloablative therapy was modeled by administration of cyclophosphamide to rats in a dose of 2.1 LD50 for 14 days. Under these conditions, increased accumulation of Evans blue dye given by gavage was observed in the blood, brain, lung, liver, kidney, and ileum (by 34, 1.6, 149, 46, 30, and 6.2 times, respectively). After intravenous injection of the dye, its accumulation was increased only in the lung and ileum. Thus, simulation of myeloablation cytostatic therapy by cyclophosphamide injection to rats is associated with impairment of the intestinal and lung—blood barriers. These alterations predispose to penetration of biologically active substances from the small intestine, gastrointestinal chyme, and lungs to the blood, thus contributing to the development of the early toxic effects of cyclophosphamide.</description><subject>Acute intoxication</subject><subject>Animals</subject><subject>Biological activity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cell Biology</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Dyes</subject><subject>Evans Blue - metabolism</subject><subject>Ileum</subject><subject>Injection</subject><subject>Internal Medicine</subject><subject>Intestines - drug effects</subject><subject>Intoxication</subject><subject>Intravenous administration</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Laboratory Medicine</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Male</subject><subject>Methylene blue</subject><subject>Pathology</subject><subject>Permeability</subject><subject>Rats</subject><subject>Small intestine</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksFu1DAQhiMEokvhBTggS0jcUuw4sZ3jdilQqVIrtHfLsSeNq8Re7ATYG0_AiSfkSXC6hW4ltEI-WDPzzW_N-M-ylwSfEIz520hwRXiOSZ3jkpU4F4-yBak4zUVRkMfZAicqL4UQR9mzGG_mEDPyNDuihKc0qxfZjysIA6jG9nbcIt-iczdCHK1TPVLOoNPee_Pr-8-1jXECdKpCsBAisg59UmNErQ_o7ItyMZGp_m4LaHIGAlp5Z-xofaok1aWeRpi1_Ter1ZxGX-3YodVW937T-bjp1GANPM-etKqP8OLuPs7W78_Wq4_5xeWH89XyItcVJ2NeVQ0XmJVVQQiwCrBq6oaDLlrdMl3w2gisOFG6NqVoGWUpMMJAyVKeKXqcvd7JboL_PKV55Y2fQpo5yoIKXFEhuLinrlUP0rrWj0HpwUYtl0wUmLOqZIcpQuuCUoITdfIPKh0Dg9XeQWtT_oHs_zXsvfBmr6ED1Y9d9P10-wcPlQ-De4rFDtTBxxiglZtgBxW2kmA5O1DuHCiTA-WtA-W8tFd3q52aAczflj-WSwDdATGV3DWE-90fkP0NYq_kMA</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Schäfer, T. 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After intravenous injection of the dye, its accumulation was increased only in the lung and ileum. Thus, simulation of myeloablation cytostatic therapy by cyclophosphamide injection to rats is associated with impairment of the intestinal and lung—blood barriers. These alterations predispose to penetration of biologically active substances from the small intestine, gastrointestinal chyme, and lungs to the blood, thus contributing to the development of the early toxic effects of cyclophosphamide.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31748869</pmid><doi>10.1007/s10517-019-04640-8</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute intoxication Animals Biological activity Biomedical and Life Sciences Biomedicine Blood Blood-Brain Barrier - drug effects Brain - drug effects Brain - metabolism Cell Biology Cyclophosphamide Cyclophosphamide - pharmacology Dyes Evans Blue - metabolism Ileum Injection Internal Medicine Intestines - drug effects Intoxication Intravenous administration Kidney - drug effects Kidney - metabolism Kidneys Laboratory Medicine Liver Liver - drug effects Liver - metabolism Lung - drug effects Lung - metabolism Male Methylene blue Pathology Permeability Rats Small intestine |
| title | Permeability of Intestinal and Blood—Tissue Barriers in Rats for Evans Blue Dye under Conditions of Acute Intoxication with Cyclophosphamide |
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