Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice
•Behavioral sensitization to ethanol (BSE) only occurred after a drug-free interval.•Repeated treatment with aripiprazole attenuated the expression of BSE.•The effects of aripiprazole on BSE did not depend on the treatment environment.•Aripiprazole prevented the reinstatement of ethanol-induced CPP....
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| Veröffentlicht in: | Drug and alcohol dependence 2020-03, Vol.208, p.107856, Article 107856 |
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| creator | Libarino-Santos, Matheus de Santana Santos, Ana Catherine Gomes Cata-Preta, Elisangela G. Barros-Santos, Thaísa Nunes Brandão, Nina Rosa Borges, Aurea Lorena Nunes Santos-Baldaia, Renan Hollais, André W. Baldaia, Marilia A. Berro, Laís F. Marinho, Eduardo A.V. Frussa-Filho, Roberto Oliveira-Lima, Alexandre J. |
| description | •Behavioral sensitization to ethanol (BSE) only occurred after a drug-free interval.•Repeated treatment with aripiprazole attenuated the expression of BSE.•The effects of aripiprazole on BSE did not depend on the treatment environment.•Aripiprazole prevented the reinstatement of ethanol-induced CPP.•Aripiprazole blocked CPP when given in the CPP apparatus, but not in the home-cage.
Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization in a context-dependent manner, suggesting that the treatment environment may modulate the therapeutic effects of aripiprazole. The present study aimed to evaluate the effects of treatment with aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice, and the role of the treatment environment in those effects.
Adult female mice were either sensitized with ethanol injections in the open-field apparatus, or conditioned with ethanol in the conditioned place preference (CPP) apparatus. Animals were then treated with vehicle or 0.1 mg/kg aripiprazole paired to the test environment (open-field or CPP apparatus) or not (home-cage treatments) for 4 alternate days, and the subsequent expression of behavioral sensitization or CPP to ethanol was evaluated during or following an ethanol re-exposure, respectively.
Repeated treatment with aripiprazole attenuated the expression of ethanol-induced behavioral sensitization regardless of the treatment environment. Treatment with aripiprazole was only effective at preventing the reinstatement of ethanol-induced CPP when paired with the ethanol-associated environment, but not when administered in the home-cage.
The present findings corroborate previous studies suggesting the effectiveness of aripiprazole for the treatment of alcohol use disorder. Our results also point to an important role of the treatment environment in the therapeutic effects of aripiprazole in rodent models of ethanol abuse. |
| doi_str_mv | 10.1016/j.drugalcdep.2020.107856 |
| format | Article |
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Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization in a context-dependent manner, suggesting that the treatment environment may modulate the therapeutic effects of aripiprazole. The present study aimed to evaluate the effects of treatment with aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice, and the role of the treatment environment in those effects.
Adult female mice were either sensitized with ethanol injections in the open-field apparatus, or conditioned with ethanol in the conditioned place preference (CPP) apparatus. Animals were then treated with vehicle or 0.1 mg/kg aripiprazole paired to the test environment (open-field or CPP apparatus) or not (home-cage treatments) for 4 alternate days, and the subsequent expression of behavioral sensitization or CPP to ethanol was evaluated during or following an ethanol re-exposure, respectively.
Repeated treatment with aripiprazole attenuated the expression of ethanol-induced behavioral sensitization regardless of the treatment environment. Treatment with aripiprazole was only effective at preventing the reinstatement of ethanol-induced CPP when paired with the ethanol-associated environment, but not when administered in the home-cage.
The present findings corroborate previous studies suggesting the effectiveness of aripiprazole for the treatment of alcohol use disorder. Our results also point to an important role of the treatment environment in the therapeutic effects of aripiprazole in rodent models of ethanol abuse.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2020.107856</identifier><identifier>PMID: 31954952</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alcohol Drinking - drug therapy ; Alcohol Drinking - psychology ; Alcohol related disorders ; Alcohol use ; Alcohol-Related Disorders - drug therapy ; Alcohol-Related Disorders - psychology ; Alcoholism ; Animal models ; Animals ; Antipsychotics ; Aripiprazole ; Aripiprazole - pharmacology ; Behavior ; Behavior, Animal - drug effects ; Behavioral sensitization ; Cages ; Cocaine ; Conditioned place preference ; Conditioning, Classical - drug effects ; Disease Models, Animal ; Dopamine ; Dopamine Agonists - pharmacology ; Dopamine D2 receptors ; Drug abuse ; Efficacy ; Environment ; Environmental effects ; Ethanol ; Female ; Females ; Hostility ; Induced ; Mice ; Narcotics ; Place preference conditioning ; Reinstatement ; Rodents ; Sensitization ; Serotonin ; Serotonin receptors ; Serotonin S1 receptors ; Serotonin S2 receptors ; Substance abuse treatment</subject><ispartof>Drug and alcohol dependence, 2020-03, Vol.208, p.107856, Article 107856</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Mar 1, 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-94026d265dd10ed23a7f97abf3fc61621606db5f669942e79e02cb23653106383</citedby><cites>FETCH-LOGICAL-c452t-94026d265dd10ed23a7f97abf3fc61621606db5f669942e79e02cb23653106383</cites><orcidid>0000-0003-4841-4117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.drugalcdep.2020.107856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31954952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Libarino-Santos, Matheus</creatorcontrib><creatorcontrib>de Santana Santos, Ana Catherine Gomes</creatorcontrib><creatorcontrib>Cata-Preta, Elisangela G.</creatorcontrib><creatorcontrib>Barros-Santos, Thaísa</creatorcontrib><creatorcontrib>Nunes Brandão, Nina Rosa</creatorcontrib><creatorcontrib>Borges, Aurea Lorena Nunes</creatorcontrib><creatorcontrib>Santos-Baldaia, Renan</creatorcontrib><creatorcontrib>Hollais, André W.</creatorcontrib><creatorcontrib>Baldaia, Marilia A.</creatorcontrib><creatorcontrib>Berro, Laís F.</creatorcontrib><creatorcontrib>Marinho, Eduardo A.V.</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><creatorcontrib>Oliveira-Lima, Alexandre J.</creatorcontrib><title>Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>•Behavioral sensitization to ethanol (BSE) only occurred after a drug-free interval.•Repeated treatment with aripiprazole attenuated the expression of BSE.•The effects of aripiprazole on BSE did not depend on the treatment environment.•Aripiprazole prevented the reinstatement of ethanol-induced CPP.•Aripiprazole blocked CPP when given in the CPP apparatus, but not in the home-cage.
Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization in a context-dependent manner, suggesting that the treatment environment may modulate the therapeutic effects of aripiprazole. The present study aimed to evaluate the effects of treatment with aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice, and the role of the treatment environment in those effects.
Adult female mice were either sensitized with ethanol injections in the open-field apparatus, or conditioned with ethanol in the conditioned place preference (CPP) apparatus. Animals were then treated with vehicle or 0.1 mg/kg aripiprazole paired to the test environment (open-field or CPP apparatus) or not (home-cage treatments) for 4 alternate days, and the subsequent expression of behavioral sensitization or CPP to ethanol was evaluated during or following an ethanol re-exposure, respectively.
Repeated treatment with aripiprazole attenuated the expression of ethanol-induced behavioral sensitization regardless of the treatment environment. Treatment with aripiprazole was only effective at preventing the reinstatement of ethanol-induced CPP when paired with the ethanol-associated environment, but not when administered in the home-cage.
The present findings corroborate previous studies suggesting the effectiveness of aripiprazole for the treatment of alcohol use disorder. Our results also point to an important role of the treatment environment in the therapeutic effects of aripiprazole in rodent models of ethanol abuse.</description><subject>Alcohol Drinking - drug therapy</subject><subject>Alcohol Drinking - psychology</subject><subject>Alcohol related disorders</subject><subject>Alcohol use</subject><subject>Alcohol-Related Disorders - drug therapy</subject><subject>Alcohol-Related Disorders - psychology</subject><subject>Alcoholism</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antipsychotics</subject><subject>Aripiprazole</subject><subject>Aripiprazole - pharmacology</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral sensitization</subject><subject>Cages</subject><subject>Cocaine</subject><subject>Conditioned place preference</subject><subject>Conditioning, Classical - drug effects</subject><subject>Disease Models, Animal</subject><subject>Dopamine</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine D2 receptors</subject><subject>Drug abuse</subject><subject>Efficacy</subject><subject>Environment</subject><subject>Environmental effects</subject><subject>Ethanol</subject><subject>Female</subject><subject>Females</subject><subject>Hostility</subject><subject>Induced</subject><subject>Mice</subject><subject>Narcotics</subject><subject>Place preference conditioning</subject><subject>Reinstatement</subject><subject>Rodents</subject><subject>Sensitization</subject><subject>Serotonin</subject><subject>Serotonin receptors</subject><subject>Serotonin S1 receptors</subject><subject>Serotonin S2 receptors</subject><subject>Substance abuse treatment</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkduOFCEQhonRuLOrr2BIvO6RQzfdXOrGU7KJidFrQkPhMOmGFuhJ3GfxYaVn1vVSbqiCr-qH-hHClOwpoeLNcW_T-kNPxsKyZ4Rtx_3QiSdoR4deNoS04inaEd6LZuipuELXOR9JXUKS5-iKU9m1smM79PtrnABHh8sBcEmgywyhYAgnn2I4xz6cL8E5MCVvrE5-8UvS9-fagKEcdIhT44NdDVg8wkGffEx6whlC9sXf6-IrqIPFJgbrt6yCy6QN4CWBgwShhlXLwaxr29kbeIGeOT1lePmw36DvH95_u_3U3H35-Pn27V1j2o6VRraECctEZy0lYBnXvZO9Hh13RlDBqCDCjp0TQsqWQS-BMDMyLjpOieADv0GvL32XFH-ukIs6xjWFKqkYH0gdI-W0UsOFMinmXN-sluRnnX4pStRmizqqf7aozRZ1saWWvnoQWMcZ7GPhXx8q8O4CQP3myUNS2fhtItanOnVlo_-_yh8E6aYJ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Libarino-Santos, Matheus</creator><creator>de Santana Santos, Ana Catherine Gomes</creator><creator>Cata-Preta, Elisangela G.</creator><creator>Barros-Santos, Thaísa</creator><creator>Nunes Brandão, Nina Rosa</creator><creator>Borges, Aurea Lorena Nunes</creator><creator>Santos-Baldaia, Renan</creator><creator>Hollais, André W.</creator><creator>Baldaia, Marilia A.</creator><creator>Berro, Laís F.</creator><creator>Marinho, Eduardo A.V.</creator><creator>Frussa-Filho, Roberto</creator><creator>Oliveira-Lima, Alexandre J.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-4841-4117</orcidid></search><sort><creationdate>20200301</creationdate><title>Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice</title><author>Libarino-Santos, Matheus ; de Santana Santos, Ana Catherine Gomes ; Cata-Preta, Elisangela G. ; Barros-Santos, Thaísa ; Nunes Brandão, Nina Rosa ; Borges, Aurea Lorena Nunes ; Santos-Baldaia, Renan ; Hollais, André W. ; Baldaia, Marilia A. ; Berro, Laís F. ; Marinho, Eduardo A.V. ; Frussa-Filho, Roberto ; Oliveira-Lima, Alexandre J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-94026d265dd10ed23a7f97abf3fc61621606db5f669942e79e02cb23653106383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alcohol Drinking - drug therapy</topic><topic>Alcohol Drinking - psychology</topic><topic>Alcohol related disorders</topic><topic>Alcohol use</topic><topic>Alcohol-Related Disorders - drug therapy</topic><topic>Alcohol-Related Disorders - psychology</topic><topic>Alcoholism</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antipsychotics</topic><topic>Aripiprazole</topic><topic>Aripiprazole - pharmacology</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral sensitization</topic><topic>Cages</topic><topic>Cocaine</topic><topic>Conditioned place preference</topic><topic>Conditioning, Classical - drug effects</topic><topic>Disease Models, Animal</topic><topic>Dopamine</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine D2 receptors</topic><topic>Drug abuse</topic><topic>Efficacy</topic><topic>Environment</topic><topic>Environmental effects</topic><topic>Ethanol</topic><topic>Female</topic><topic>Females</topic><topic>Hostility</topic><topic>Induced</topic><topic>Mice</topic><topic>Narcotics</topic><topic>Place preference conditioning</topic><topic>Reinstatement</topic><topic>Rodents</topic><topic>Sensitization</topic><topic>Serotonin</topic><topic>Serotonin receptors</topic><topic>Serotonin S1 receptors</topic><topic>Serotonin S2 receptors</topic><topic>Substance abuse treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Libarino-Santos, Matheus</creatorcontrib><creatorcontrib>de Santana Santos, Ana Catherine Gomes</creatorcontrib><creatorcontrib>Cata-Preta, Elisangela G.</creatorcontrib><creatorcontrib>Barros-Santos, Thaísa</creatorcontrib><creatorcontrib>Nunes Brandão, Nina Rosa</creatorcontrib><creatorcontrib>Borges, Aurea Lorena Nunes</creatorcontrib><creatorcontrib>Santos-Baldaia, Renan</creatorcontrib><creatorcontrib>Hollais, André W.</creatorcontrib><creatorcontrib>Baldaia, Marilia A.</creatorcontrib><creatorcontrib>Berro, Laís F.</creatorcontrib><creatorcontrib>Marinho, Eduardo A.V.</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><creatorcontrib>Oliveira-Lima, Alexandre J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Libarino-Santos, Matheus</au><au>de Santana Santos, Ana Catherine Gomes</au><au>Cata-Preta, Elisangela G.</au><au>Barros-Santos, Thaísa</au><au>Nunes Brandão, Nina Rosa</au><au>Borges, Aurea Lorena Nunes</au><au>Santos-Baldaia, Renan</au><au>Hollais, André W.</au><au>Baldaia, Marilia A.</au><au>Berro, Laís F.</au><au>Marinho, Eduardo A.V.</au><au>Frussa-Filho, Roberto</au><au>Oliveira-Lima, Alexandre J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>208</volume><spage>107856</spage><pages>107856-</pages><artnum>107856</artnum><issn>0376-8716</issn><eissn>1879-0046</eissn><abstract>•Behavioral sensitization to ethanol (BSE) only occurred after a drug-free interval.•Repeated treatment with aripiprazole attenuated the expression of BSE.•The effects of aripiprazole on BSE did not depend on the treatment environment.•Aripiprazole prevented the reinstatement of ethanol-induced CPP.•Aripiprazole blocked CPP when given in the CPP apparatus, but not in the home-cage.
Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated that treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization in a context-dependent manner, suggesting that the treatment environment may modulate the therapeutic effects of aripiprazole. The present study aimed to evaluate the effects of treatment with aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice, and the role of the treatment environment in those effects.
Adult female mice were either sensitized with ethanol injections in the open-field apparatus, or conditioned with ethanol in the conditioned place preference (CPP) apparatus. Animals were then treated with vehicle or 0.1 mg/kg aripiprazole paired to the test environment (open-field or CPP apparatus) or not (home-cage treatments) for 4 alternate days, and the subsequent expression of behavioral sensitization or CPP to ethanol was evaluated during or following an ethanol re-exposure, respectively.
Repeated treatment with aripiprazole attenuated the expression of ethanol-induced behavioral sensitization regardless of the treatment environment. Treatment with aripiprazole was only effective at preventing the reinstatement of ethanol-induced CPP when paired with the ethanol-associated environment, but not when administered in the home-cage.
The present findings corroborate previous studies suggesting the effectiveness of aripiprazole for the treatment of alcohol use disorder. Our results also point to an important role of the treatment environment in the therapeutic effects of aripiprazole in rodent models of ethanol abuse.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>31954952</pmid><doi>10.1016/j.drugalcdep.2020.107856</doi><orcidid>https://orcid.org/0000-0003-4841-4117</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Alcohol Drinking - drug therapy Alcohol Drinking - psychology Alcohol related disorders Alcohol use Alcohol-Related Disorders - drug therapy Alcohol-Related Disorders - psychology Alcoholism Animal models Animals Antipsychotics Aripiprazole Aripiprazole - pharmacology Behavior Behavior, Animal - drug effects Behavioral sensitization Cages Cocaine Conditioned place preference Conditioning, Classical - drug effects Disease Models, Animal Dopamine Dopamine Agonists - pharmacology Dopamine D2 receptors Drug abuse Efficacy Environment Environmental effects Ethanol Female Females Hostility Induced Mice Narcotics Place preference conditioning Reinstatement Rodents Sensitization Serotonin Serotonin receptors Serotonin S1 receptors Serotonin S2 receptors Substance abuse treatment |
| title | Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice |
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