What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation

Transposable elements (TEs) are sequences currently or historically mobile, and are present across all eukaryotic genomes. A growing interest in understanding the regulation and function of TEs has revealed seemingly dichotomous roles for these elements in evolution, development, and disease. On the...

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Veröffentlicht in:	BioEssays 2020-04, Vol.42 (4), p.e1900232-n/a
Hauptverfasser:	Percharde, Michelle, Sultana, Tania, Ramalho‐Santos, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biological evolution Chromatin chromatin organization Deoxyribonucleic acid Deregulation DNA endogenous retroviruses Gene expression Genomes Genomics LINE1 Mammals mutagenesis Mutation preimplantation development Senescence transposable elements Transposons
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