Stable and Monochromatic All-Inorganic Halide Perovskite Assisted by Hollow Carbon Nitride Nanosphere for Ratiometric Electrochemiluminescence Bioanalysis
Lead halide perovskites have been promising electrochemiluminescence (ECL) candidates because of their excellent photophysical attributes, but their poor stability has severely restricted ECL applications. Herein, the in situ assembly of all-inorganic perovskite CsPbBr3 nanocrystals (CPB) into hollo...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2020-03, Vol.92 (5), p.4123-4130 |
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| creator | Cao, Yue Zhu, Wenlei Wei, Huifang Ma, Cheng Lin, Yuehe Zhu, Jun-Jie |
| description | Lead halide perovskites have been promising electrochemiluminescence (ECL) candidates because of their excellent photophysical attributes, but their poor stability has severely restricted ECL applications. Herein, the in situ assembly of all-inorganic perovskite CsPbBr3 nanocrystals (CPB) into hollow graphitic carbon nitride nanospheres (HCNS) were described as a novel ECL emitter. The architecture guaranteed not only improved stability because of the peripheral HCNS protecting shell but also high-performance ECL of CPB because of a matching band-edge arrangement. Dual-ECL readouts were obtained from the nanocomposite including an anodic ECL from CPB and a cathodic ECL from HCNS. The former displayed prominent color purity to construct an efficient ECL resonance energy transfer system, and the latter served as an internal standard for a ratiometric analysis. A well-designed DNA probe was further utilized for the targeting of CD44 receptors on the MCF-7 cell surface and the double signal amplification. The sensing strategy exhibited good analytical performance for MCF-7 cells, ranging from 1.0 × 103 to 3.2 × 105 cells mL–1 with a detection limit of 320 cells mL–1. Sensitive and accurate evaluation of CD44 expression was finally achieved at 0.22 pM. This work is the first attempt to use halide perovskite for reliable ECL bioanalysis and provides a perspective to design a perovskite-based nanocomposite as a high-performance ECL emitter for its exclusive ECL system. |
| doi_str_mv | 10.1021/acs.analchem.0c00070 |
| format | Article |
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Herein, the in situ assembly of all-inorganic perovskite CsPbBr3 nanocrystals (CPB) into hollow graphitic carbon nitride nanospheres (HCNS) were described as a novel ECL emitter. The architecture guaranteed not only improved stability because of the peripheral HCNS protecting shell but also high-performance ECL of CPB because of a matching band-edge arrangement. Dual-ECL readouts were obtained from the nanocomposite including an anodic ECL from CPB and a cathodic ECL from HCNS. The former displayed prominent color purity to construct an efficient ECL resonance energy transfer system, and the latter served as an internal standard for a ratiometric analysis. A well-designed DNA probe was further utilized for the targeting of CD44 receptors on the MCF-7 cell surface and the double signal amplification. The sensing strategy exhibited good analytical performance for MCF-7 cells, ranging from 1.0 × 103 to 3.2 × 105 cells mL–1 with a detection limit of 320 cells mL–1. Sensitive and accurate evaluation of CD44 expression was finally achieved at 0.22 pM. This work is the first attempt to use halide perovskite for reliable ECL bioanalysis and provides a perspective to design a perovskite-based nanocomposite as a high-performance ECL emitter for its exclusive ECL system.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.0c00070</identifier><identifier>PMID: 32046479</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Calcium Compounds - chemistry ; Carbon ; Carbon nitride ; CD44 antigen ; Cell surface ; Chemistry ; Deoxyribonucleic acid ; DNA ; DNA Probes - chemistry ; Electrochemical Techniques - methods ; Electrochemiluminescence ; Emitters ; Energy transfer ; Graphite - chemistry ; Humans ; Hyaluronan Receptors - chemistry ; Hyaluronan Receptors - metabolism ; Lead compounds ; Limit of Detection ; Luminescent Measurements ; MCF-7 Cells ; Metal halides ; Microscopy, Confocal ; Nanocomposites ; Nanocrystals ; Nanospheres ; Nanospheres - chemistry ; Nitrogen Compounds - chemistry ; Oxides - chemistry ; Perovskites ; Receptors ; Sensitivity analysis ; Titanium - chemistry</subject><ispartof>Analytical chemistry (Washington), 2020-03, Vol.92 (5), p.4123-4130</ispartof><rights>Copyright American Chemical Society Mar 3, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-676a67585cc1619083f2ce4b88ba38014e18997f77b244312b02606bf6ed40773</citedby><cites>FETCH-LOGICAL-a376t-676a67585cc1619083f2ce4b88ba38014e18997f77b244312b02606bf6ed40773</cites><orcidid>0000-0003-3791-7587 ; 0000-0002-8934-7195 ; 0000-0001-5729-8483 ; 0000-0002-8201-1285</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c00070$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.0c00070$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32046479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>Zhu, Wenlei</creatorcontrib><creatorcontrib>Wei, Huifang</creatorcontrib><creatorcontrib>Ma, Cheng</creatorcontrib><creatorcontrib>Lin, Yuehe</creatorcontrib><creatorcontrib>Zhu, Jun-Jie</creatorcontrib><title>Stable and Monochromatic All-Inorganic Halide Perovskite Assisted by Hollow Carbon Nitride Nanosphere for Ratiometric Electrochemiluminescence Bioanalysis</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Lead halide perovskites have been promising electrochemiluminescence (ECL) candidates because of their excellent photophysical attributes, but their poor stability has severely restricted ECL applications. Herein, the in situ assembly of all-inorganic perovskite CsPbBr3 nanocrystals (CPB) into hollow graphitic carbon nitride nanospheres (HCNS) were described as a novel ECL emitter. The architecture guaranteed not only improved stability because of the peripheral HCNS protecting shell but also high-performance ECL of CPB because of a matching band-edge arrangement. Dual-ECL readouts were obtained from the nanocomposite including an anodic ECL from CPB and a cathodic ECL from HCNS. The former displayed prominent color purity to construct an efficient ECL resonance energy transfer system, and the latter served as an internal standard for a ratiometric analysis. A well-designed DNA probe was further utilized for the targeting of CD44 receptors on the MCF-7 cell surface and the double signal amplification. The sensing strategy exhibited good analytical performance for MCF-7 cells, ranging from 1.0 × 103 to 3.2 × 105 cells mL–1 with a detection limit of 320 cells mL–1. Sensitive and accurate evaluation of CD44 expression was finally achieved at 0.22 pM. This work is the first attempt to use halide perovskite for reliable ECL bioanalysis and provides a perspective to design a perovskite-based nanocomposite as a high-performance ECL emitter for its exclusive ECL system.</description><subject>Calcium Compounds - chemistry</subject><subject>Carbon</subject><subject>Carbon nitride</subject><subject>CD44 antigen</subject><subject>Cell surface</subject><subject>Chemistry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Probes - chemistry</subject><subject>Electrochemical Techniques - methods</subject><subject>Electrochemiluminescence</subject><subject>Emitters</subject><subject>Energy transfer</subject><subject>Graphite - chemistry</subject><subject>Humans</subject><subject>Hyaluronan Receptors - chemistry</subject><subject>Hyaluronan Receptors - metabolism</subject><subject>Lead compounds</subject><subject>Limit of Detection</subject><subject>Luminescent Measurements</subject><subject>MCF-7 Cells</subject><subject>Metal halides</subject><subject>Microscopy, Confocal</subject><subject>Nanocomposites</subject><subject>Nanocrystals</subject><subject>Nanospheres</subject><subject>Nanospheres - chemistry</subject><subject>Nitrogen Compounds - chemistry</subject><subject>Oxides - chemistry</subject><subject>Perovskites</subject><subject>Receptors</subject><subject>Sensitivity analysis</subject><subject>Titanium - chemistry</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuGyEQhlHVqnHTvEFVIfW87sCuYffoWEkcKU2rpDmvgJ2tSVlwYJ3Kr9KnLSs7OfYyaOD_vxn0E_KJwZwBZ1-VSXPllTMbHOZgAEDCGzJjCw6FqGv-lszyXVlwCXBCPqT0CMAYMPGenJQcKlHJZkb-3o9KO6TKd_Rb8MFsYhjUaA1dOldc-xB_KZ-7tXK2Q_oDY3hOv-2IdJmSTSN2VO_pOjgX_tCVijp4emvHOIlvlQ9pu8GItA-R3mVsGDC_GXrh0IwxTLtbtxusx2TQG6TnNkyf2mf2R_KuVy7h2fE8JQ-XFz9X6-Lm-9X1anlTqFKKsRBSKCEX9cIYJlgDddlzg5Wua63KGliFrG4a2UupeVWVjGvgAoTuBXYVSFmeki8H7jaGpx2msX0Mu5iXSC0vpZSQS5NV1UFlYkgpYt9uox1U3LcM2imQNgfSvgTSHgPJts9H-E4P2L2aXhLIAjgIJvvr4P8y_wH0V5xm</recordid><startdate>20200303</startdate><enddate>20200303</enddate><creator>Cao, Yue</creator><creator>Zhu, Wenlei</creator><creator>Wei, Huifang</creator><creator>Ma, Cheng</creator><creator>Lin, Yuehe</creator><creator>Zhu, Jun-Jie</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-3791-7587</orcidid><orcidid>https://orcid.org/0000-0002-8934-7195</orcidid><orcidid>https://orcid.org/0000-0001-5729-8483</orcidid><orcidid>https://orcid.org/0000-0002-8201-1285</orcidid></search><sort><creationdate>20200303</creationdate><title>Stable and Monochromatic All-Inorganic Halide Perovskite Assisted by Hollow Carbon Nitride Nanosphere for Ratiometric Electrochemiluminescence Bioanalysis</title><author>Cao, Yue ; Zhu, Wenlei ; Wei, Huifang ; Ma, Cheng ; Lin, Yuehe ; Zhu, Jun-Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-676a67585cc1619083f2ce4b88ba38014e18997f77b244312b02606bf6ed40773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Calcium Compounds - chemistry</topic><topic>Carbon</topic><topic>Carbon nitride</topic><topic>CD44 antigen</topic><topic>Cell surface</topic><topic>Chemistry</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Probes - chemistry</topic><topic>Electrochemical Techniques - methods</topic><topic>Electrochemiluminescence</topic><topic>Emitters</topic><topic>Energy transfer</topic><topic>Graphite - chemistry</topic><topic>Humans</topic><topic>Hyaluronan Receptors - chemistry</topic><topic>Hyaluronan Receptors - metabolism</topic><topic>Lead compounds</topic><topic>Limit of Detection</topic><topic>Luminescent Measurements</topic><topic>MCF-7 Cells</topic><topic>Metal halides</topic><topic>Microscopy, Confocal</topic><topic>Nanocomposites</topic><topic>Nanocrystals</topic><topic>Nanospheres</topic><topic>Nanospheres - chemistry</topic><topic>Nitrogen Compounds - chemistry</topic><topic>Oxides - chemistry</topic><topic>Perovskites</topic><topic>Receptors</topic><topic>Sensitivity analysis</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Yue</creatorcontrib><creatorcontrib>Zhu, Wenlei</creatorcontrib><creatorcontrib>Wei, Huifang</creatorcontrib><creatorcontrib>Ma, Cheng</creatorcontrib><creatorcontrib>Lin, Yuehe</creatorcontrib><creatorcontrib>Zhu, Jun-Jie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Yue</au><au>Zhu, Wenlei</au><au>Wei, Huifang</au><au>Ma, Cheng</au><au>Lin, Yuehe</au><au>Zhu, Jun-Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stable and Monochromatic All-Inorganic Halide Perovskite Assisted by Hollow Carbon Nitride Nanosphere for Ratiometric Electrochemiluminescence Bioanalysis</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2020-03-03</date><risdate>2020</risdate><volume>92</volume><issue>5</issue><spage>4123</spage><epage>4130</epage><pages>4123-4130</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>Lead halide perovskites have been promising electrochemiluminescence (ECL) candidates because of their excellent photophysical attributes, but their poor stability has severely restricted ECL applications. Herein, the in situ assembly of all-inorganic perovskite CsPbBr3 nanocrystals (CPB) into hollow graphitic carbon nitride nanospheres (HCNS) were described as a novel ECL emitter. The architecture guaranteed not only improved stability because of the peripheral HCNS protecting shell but also high-performance ECL of CPB because of a matching band-edge arrangement. Dual-ECL readouts were obtained from the nanocomposite including an anodic ECL from CPB and a cathodic ECL from HCNS. The former displayed prominent color purity to construct an efficient ECL resonance energy transfer system, and the latter served as an internal standard for a ratiometric analysis. A well-designed DNA probe was further utilized for the targeting of CD44 receptors on the MCF-7 cell surface and the double signal amplification. The sensing strategy exhibited good analytical performance for MCF-7 cells, ranging from 1.0 × 103 to 3.2 × 105 cells mL–1 with a detection limit of 320 cells mL–1. Sensitive and accurate evaluation of CD44 expression was finally achieved at 0.22 pM. This work is the first attempt to use halide perovskite for reliable ECL bioanalysis and provides a perspective to design a perovskite-based nanocomposite as a high-performance ECL emitter for its exclusive ECL system.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>32046479</pmid><doi>10.1021/acs.analchem.0c00070</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3791-7587</orcidid><orcidid>https://orcid.org/0000-0002-8934-7195</orcidid><orcidid>https://orcid.org/0000-0001-5729-8483</orcidid><orcidid>https://orcid.org/0000-0002-8201-1285</orcidid></addata></record> |
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| subjects | Calcium Compounds - chemistry Carbon Carbon nitride CD44 antigen Cell surface Chemistry Deoxyribonucleic acid DNA DNA Probes - chemistry Electrochemical Techniques - methods Electrochemiluminescence Emitters Energy transfer Graphite - chemistry Humans Hyaluronan Receptors - chemistry Hyaluronan Receptors - metabolism Lead compounds Limit of Detection Luminescent Measurements MCF-7 Cells Metal halides Microscopy, Confocal Nanocomposites Nanocrystals Nanospheres Nanospheres - chemistry Nitrogen Compounds - chemistry Oxides - chemistry Perovskites Receptors Sensitivity analysis Titanium - chemistry |
| title | Stable and Monochromatic All-Inorganic Halide Perovskite Assisted by Hollow Carbon Nitride Nanosphere for Ratiometric Electrochemiluminescence Bioanalysis |
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