Comparative quantitative study of the Total anthracen derivatives in combined preparations of Rheum palmatum

Polygonaceae - a medicinal plant, widely used in traditional medicine of the European Union, homeopathy, Chinese medicine, is promising for use in domestic medicine due to the content of a large number of anthracen derivatives, causing laxative effect, and tannins that have the opposite effect on the gastrointestinal tract. [...]the nature of the action of extracts from Rheum palmatum roots on the gastrointestinal tract depends on the dosage: astringent, anti-inflammatory effect is provided by small amounts of extracts, laxative effect is on the contrary large amounts.1,2,3 Laxative effect of anthracen derivatives contained in the roots of Rheum palmatum, associated with the reflex effect on intestinal peristalsis, which causes its accelerated emptying. According to the mechanism of action of drugs based on Rheum palmatum belong to the group of laxatives that cause irritation of the receptors of the mucous membrane of the intestine. The study of electronic spectra showed that the electronic spectra of alkaline-ammonia solutions of aqueous-alcoholic extracts of the contents of capsules and tablets coincide with the spectrum of the aqueous-alcoholic solution of the frangula-emodin standard, and the maximum absorption is at 510 nm, which is characteristic of the alkaline-ammonia solution of aqueous-alcoholic extraction from the roots of Rheum palmatum (Fig. 1). [...]the value of 510 nm can be used as the analytical wavelength, and the standard sample can be the dominant anthraglycoside - frangulaemodin, and in the absence of a standard in the calculation formula, the theoretical value of the specific absorption index can be used.