Synthesis and Antidiabetic Evaluation of Some New Coumarin Coupled 4-Thiazolidinone Derivatives

[...]an attempt was made towards the incorporation of 4thiazolidinone with coumarin moiety and to probe how this combination could influence the antidiabetic activity. All the chemicals were of analytical grade: 4-hydroxy coumarin, pyridine, piperidine, substituted aromatic amine, acetyl chloride, ethanol, thioglycollic acid and dioxane. All IR spectra were recorded in Alpha Bruker using ATR method. ¾ NMR spectra were recorded on Bruker spectrophotometer (400 MHz) in DMSO-d6 solvent using tetra methyl silane (TMS) as an internal standard. General Procedure: Synthesis of 3-acetyl-4-hydroxy coumarin11 4-hydroxy coumarin (2.4g) was dissolved in pyridine (30ml) and few drops of piperidine were added and the contents were cooled to 0-4°C. Acetyl chloride (2.4g) was added to the reaction mixture and shaken for 48 hours.