Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies
The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we...
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| Veröffentlicht in: | Nature communications 2020-03, Vol.11 (1), p.1364-1364, Article 1364 |
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| creator | Mabuchi, Seiji Komura, Naoko Sasano, Tomoyuki Shimura, Kotaro Yokoi, Eriko Kozasa, Katsumi Kuroda, Hiromasa Takahashi, Ryoko Kawano, Mahiru Matsumoto, Yuri Kato, Hiroki Hatazawa, Jun Kimura, Tadashi |
| description | The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate the impact of pretreatment tumor-related leukocytosis (TRL) on the diagnostic performance of 18F-FDG-PET/CT in detecting pelvic and paraaortic lymph node metastasis. We demonstrate that pretreatment TRL misleads 18F-FDG-PET/CT during lymph node staging in gynecological malignancies. In the mechanistic investigations, we show that the false-positive 18F-FDG-PET/CT result for detecting nodal metastasis can be reproduced in animal models of TRL-positive cancer bearing G-CSF expressing cervical cancer cells. We also show that increased 18F-FDG uptake in non-metastatic nodes can be explained by the MDSC-mediated premetastatic niche formation in which proinflammatory factors, such as S100A8 or S100A9, are abundantly expressed. Together, our results suggest that the MDSC-mediated premetastatic niche created in the lymph node of TRL-positive patients misleads 18F-FDG-PET/CT for detecting nodal metastasis.
Modern imaging techniques can detect cancer cells in the lymph nodes of cancer patients. In this study, the authors show that tumour related leukocytosis, a phenomenon where leukocytes are increased in number, can lead to the false positive detection of cancer cells in lymph nodes. |
| doi_str_mv | 10.1038/s41467-020-15186-z |
| format | Article |
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Modern imaging techniques can detect cancer cells in the lymph nodes of cancer patients. In this study, the authors show that tumour related leukocytosis, a phenomenon where leukocytes are increased in number, can lead to the false positive detection of cancer cells in lymph nodes.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/s41467-020-15186-z</identifier><identifier>PMID: 32170086</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/109 ; 13/21 ; 13/31 ; 13/51 ; 38/77 ; 59 ; 59/78 ; 631/67 ; 64/60 ; 64/86 ; 692/4028 ; Animal models ; Animals ; Cancer ; Cell Line, Tumor ; Cervical cancer ; Computed tomography ; Diagnostic systems ; Disease Models, Animal ; Emissions ; Female ; Fluorine ; Fluorine isotopes ; Fluorodeoxyglucose F18 ; Glycolysis ; Granulocyte colony-stimulating factor ; Gynecological cancer ; Gynecology ; Humanities and Social Sciences ; Humans ; Imaging techniques ; Inflammation ; Leukocytes ; Leukocytosis ; Leukocytosis - diagnostic imaging ; Leukocytosis - pathology ; Lymph nodes ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymphatic system ; Metastases ; Metastasis ; Middle Aged ; multidisciplinary ; Neoplasms - diagnostic imaging ; Neoplasms - pathology ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography - methods ; Pretreatment ; Science ; Science (multidisciplinary) ; Tomography ; Tumors ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Nature communications, 2020-03, Vol.11 (1), p.1364-1364, Article 1364</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-784c5c1f45d47d4b9c773516c9810a2619ac13d364d548dea698bc4abd1a951e3</citedby><cites>FETCH-LOGICAL-c690t-784c5c1f45d47d4b9c773516c9810a2619ac13d364d548dea698bc4abd1a951e3</cites><orcidid>0000-0003-0838-6772 ; 0000-0003-4300-5517</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069975/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069975/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32170086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mabuchi, Seiji</creatorcontrib><creatorcontrib>Komura, Naoko</creatorcontrib><creatorcontrib>Sasano, Tomoyuki</creatorcontrib><creatorcontrib>Shimura, Kotaro</creatorcontrib><creatorcontrib>Yokoi, Eriko</creatorcontrib><creatorcontrib>Kozasa, Katsumi</creatorcontrib><creatorcontrib>Kuroda, Hiromasa</creatorcontrib><creatorcontrib>Takahashi, Ryoko</creatorcontrib><creatorcontrib>Kawano, Mahiru</creatorcontrib><creatorcontrib>Matsumoto, Yuri</creatorcontrib><creatorcontrib>Kato, Hiroki</creatorcontrib><creatorcontrib>Hatazawa, Jun</creatorcontrib><creatorcontrib>Kimura, Tadashi</creatorcontrib><title>Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate the impact of pretreatment tumor-related leukocytosis (TRL) on the diagnostic performance of 18F-FDG-PET/CT in detecting pelvic and paraaortic lymph node metastasis. We demonstrate that pretreatment TRL misleads 18F-FDG-PET/CT during lymph node staging in gynecological malignancies. In the mechanistic investigations, we show that the false-positive 18F-FDG-PET/CT result for detecting nodal metastasis can be reproduced in animal models of TRL-positive cancer bearing G-CSF expressing cervical cancer cells. We also show that increased 18F-FDG uptake in non-metastatic nodes can be explained by the MDSC-mediated premetastatic niche formation in which proinflammatory factors, such as S100A8 or S100A9, are abundantly expressed. Together, our results suggest that the MDSC-mediated premetastatic niche created in the lymph node of TRL-positive patients misleads 18F-FDG-PET/CT for detecting nodal metastasis.
Modern imaging techniques can detect cancer cells in the lymph nodes of cancer patients. In this study, the authors show that tumour related leukocytosis, a phenomenon where leukocytes are increased in number, can lead to the false positive detection of cancer cells in lymph nodes.</description><subject>13/1</subject><subject>13/109</subject><subject>13/21</subject><subject>13/31</subject><subject>13/51</subject><subject>38/77</subject><subject>59</subject><subject>59/78</subject><subject>631/67</subject><subject>64/60</subject><subject>64/86</subject><subject>692/4028</subject><subject>Animal models</subject><subject>Animals</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cervical cancer</subject><subject>Computed tomography</subject><subject>Diagnostic systems</subject><subject>Disease Models, Animal</subject><subject>Emissions</subject><subject>Female</subject><subject>Fluorine</subject><subject>Fluorine isotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glycolysis</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Gynecological cancer</subject><subject>Gynecology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Imaging techniques</subject><subject>Inflammation</subject><subject>Leukocytes</subject><subject>Leukocytosis</subject><subject>Leukocytosis - diagnostic imaging</subject><subject>Leukocytosis - pathology</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - pathology</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Pretreatment</subject><subject>Science</subject><subject>Science 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Eriko</au><au>Kozasa, Katsumi</au><au>Kuroda, Hiromasa</au><au>Takahashi, Ryoko</au><au>Kawano, Mahiru</au><au>Matsumoto, Yuri</au><au>Kato, Hiroki</au><au>Hatazawa, Jun</au><au>Kimura, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2020-03-13</date><risdate>2020</risdate><volume>11</volume><issue>1</issue><spage>1364</spage><epage>1364</epage><pages>1364-1364</pages><artnum>1364</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>The accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT) can be influenced by the increased glycolytic activity of inflammatory lesions. Here, using clinical data obtained from gynecological cancer patients, tumor samples and animal models, we investigate the impact of pretreatment tumor-related leukocytosis (TRL) on the diagnostic performance of 18F-FDG-PET/CT in detecting pelvic and paraaortic lymph node metastasis. We demonstrate that pretreatment TRL misleads 18F-FDG-PET/CT during lymph node staging in gynecological malignancies. In the mechanistic investigations, we show that the false-positive 18F-FDG-PET/CT result for detecting nodal metastasis can be reproduced in animal models of TRL-positive cancer bearing G-CSF expressing cervical cancer cells. We also show that increased 18F-FDG uptake in non-metastatic nodes can be explained by the MDSC-mediated premetastatic niche formation in which proinflammatory factors, such as S100A8 or S100A9, are abundantly expressed. Together, our results suggest that the MDSC-mediated premetastatic niche created in the lymph node of TRL-positive patients misleads 18F-FDG-PET/CT for detecting nodal metastasis.
Modern imaging techniques can detect cancer cells in the lymph nodes of cancer patients. In this study, the authors show that tumour related leukocytosis, a phenomenon where leukocytes are increased in number, can lead to the false positive detection of cancer cells in lymph nodes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32170086</pmid><doi>10.1038/s41467-020-15186-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0838-6772</orcidid><orcidid>https://orcid.org/0000-0003-4300-5517</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_proquest_journals_2376946254 |
| source | SpringerOpen; MEDLINE; Nature Free; PubMed Central; Directory of Open Access Journals; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | 13/1 13/109 13/21 13/31 13/51 38/77 59 59/78 631/67 64/60 64/86 692/4028 Animal models Animals Cancer Cell Line, Tumor Cervical cancer Computed tomography Diagnostic systems Disease Models, Animal Emissions Female Fluorine Fluorine isotopes Fluorodeoxyglucose F18 Glycolysis Granulocyte colony-stimulating factor Gynecological cancer Gynecology Humanities and Social Sciences Humans Imaging techniques Inflammation Leukocytes Leukocytosis Leukocytosis - diagnostic imaging Leukocytosis - pathology Lymph nodes Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymphatic system Metastases Metastasis Middle Aged multidisciplinary Neoplasms - diagnostic imaging Neoplasms - pathology Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography - methods Pretreatment Science Science (multidisciplinary) Tomography Tumors Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology |
| title | Pretreatment tumor-related leukocytosis misleads positron emission tomography-computed tomography during lymph node staging in gynecological malignancies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A51%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pretreatment%20tumor-related%20leukocytosis%20misleads%20positron%20emission%20tomography-computed%20tomography%20during%20lymph%20node%20staging%20in%20gynecological%20malignancies&rft.jtitle=Nature%20communications&rft.au=Mabuchi,%20Seiji&rft.date=2020-03-13&rft.volume=11&rft.issue=1&rft.spage=1364&rft.epage=1364&rft.pages=1364-1364&rft.artnum=1364&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/s41467-020-15186-z&rft_dat=%3Cproquest_doaj_%3E2376946254%3C/proquest_doaj_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2376946254&rft_id=info:pmid/32170086&rft_doaj_id=oai_doaj_org_article_b8525580108c49c3872c6765a3364aec&rfr_iscdi=true |