Evaluation of body composition as a potential biomarker in spinal muscular atrophy
Introduction We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments. Methods Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric me...
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| Veröffentlicht in: | Muscle & nerve 2020-04, Vol.61 (4), p.530-534 |
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| creator | Baranello, Giovanni De Amicis, Ramona Arnoldi, Maria Teresa Zanin, Riccardo Mastella, Chiara Masson, Riccardo Leone, Alessandro Alberti, Katia Foppiani, Andrea Battezzati, Alberto Bertoli, Simona |
| description | Introduction
We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments.
Methods
Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII).
Results
Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.
Discussion
BC shows promise as a potential biomarker for SMA, but further studies are needed. |
| doi_str_mv | 10.1002/mus.26823 |
| format | Article |
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We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments.
Methods
Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII).
Results
Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.
Discussion
BC shows promise as a potential biomarker for SMA, but further studies are needed.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26823</identifier><identifier>PMID: 32012296</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Absorptiometry, Photon ; Adipose Tissue - diagnostic imaging ; Adipose Tissue - physiopathology ; Anthropometry ; Assessments ; Atrophy ; Biomarkers ; Body composition ; Body Composition - physiology ; Body fat ; Body mass ; Body mass index ; Body size ; Child ; Child, Preschool ; Children ; Correlation ; Cross-Sectional Studies ; fat‐free mass ; Female ; Hammersmith Functional Motor Scale―Expanded ; Human motion ; Humans ; Infant ; Male ; Muscular Atrophy, Spinal - diagnosis ; Muscular Atrophy, Spinal - diagnostic imaging ; Muscular Atrophy, Spinal - physiopathology ; Neuromuscular diseases ; Spinal muscular atrophy ; The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders</subject><ispartof>Muscle & nerve, 2020-04, Vol.61 (4), p.530-534</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-48a5d35fbf7085feb38356326f42baf6fd3680c4456293783c08e045073de54c3</citedby><cites>FETCH-LOGICAL-c3883-48a5d35fbf7085feb38356326f42baf6fd3680c4456293783c08e045073de54c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26823$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26823$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32012296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baranello, Giovanni</creatorcontrib><creatorcontrib>De Amicis, Ramona</creatorcontrib><creatorcontrib>Arnoldi, Maria Teresa</creatorcontrib><creatorcontrib>Zanin, Riccardo</creatorcontrib><creatorcontrib>Mastella, Chiara</creatorcontrib><creatorcontrib>Masson, Riccardo</creatorcontrib><creatorcontrib>Leone, Alessandro</creatorcontrib><creatorcontrib>Alberti, Katia</creatorcontrib><creatorcontrib>Foppiani, Andrea</creatorcontrib><creatorcontrib>Battezzati, Alberto</creatorcontrib><creatorcontrib>Bertoli, Simona</creatorcontrib><title>Evaluation of body composition as a potential biomarker in spinal muscular atrophy</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction
We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments.
Methods
Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII).
Results
Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.
Discussion
BC shows promise as a potential biomarker for SMA, but further studies are needed.</description><subject>Absorptiometry, Photon</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - physiopathology</subject><subject>Anthropometry</subject><subject>Assessments</subject><subject>Atrophy</subject><subject>Biomarkers</subject><subject>Body composition</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>fat‐free mass</subject><subject>Female</subject><subject>Hammersmith Functional Motor Scale―Expanded</subject><subject>Human motion</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Muscular Atrophy, Spinal - diagnosis</subject><subject>Muscular Atrophy, Spinal - diagnostic imaging</subject><subject>Muscular Atrophy, Spinal - physiopathology</subject><subject>Neuromuscular diseases</subject><subject>Spinal muscular atrophy</subject><subject>The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAUhYMozji68A9IwJWLzqR5NV3KMD5gRFAH3JW0TTBj29SkVfrvjdPRnasLh--ee-4B4DxG8xghvKh7P8dcYHIApjFKk4iyVByCKYqpiDhJXyfgxPstQigWPDkGE4JRjHHKp-Bp9SmrXnbGNtBqmNtygIWtW-vNTpMeStjaTjWdkRXMja2le1cOmgb61jRBC9eLvpIOys7Z9m04BUdaVl6d7ecMbG5WL8u7aP14e7-8XkcFEYJEVEhWEqZznSDBtMqJIIwTzDXFudRcl4QLVFDKOE5JIkiBhEKUoYSUitGCzMDl6Ns6-9Er32Vb27uQyGeYJFyEbY4CdTVShbPeO6Wz1pnww5DFKPtpLwv5s117gb3YO_Z5rco_8reuACxG4MtUavjfKXvYPI-W32e8ePc</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Baranello, Giovanni</creator><creator>De Amicis, Ramona</creator><creator>Arnoldi, Maria Teresa</creator><creator>Zanin, Riccardo</creator><creator>Mastella, Chiara</creator><creator>Masson, Riccardo</creator><creator>Leone, Alessandro</creator><creator>Alberti, Katia</creator><creator>Foppiani, Andrea</creator><creator>Battezzati, Alberto</creator><creator>Bertoli, Simona</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>202004</creationdate><title>Evaluation of body composition as a potential biomarker in spinal muscular atrophy</title><author>Baranello, Giovanni ; De Amicis, Ramona ; Arnoldi, Maria Teresa ; Zanin, Riccardo ; Mastella, Chiara ; Masson, Riccardo ; Leone, Alessandro ; Alberti, Katia ; Foppiani, Andrea ; Battezzati, Alberto ; Bertoli, Simona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-48a5d35fbf7085feb38356326f42baf6fd3680c4456293783c08e045073de54c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Absorptiometry, Photon</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - physiopathology</topic><topic>Anthropometry</topic><topic>Assessments</topic><topic>Atrophy</topic><topic>Biomarkers</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>fat‐free mass</topic><topic>Female</topic><topic>Hammersmith Functional Motor Scale―Expanded</topic><topic>Human motion</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Muscular Atrophy, Spinal - diagnosis</topic><topic>Muscular Atrophy, Spinal - diagnostic imaging</topic><topic>Muscular Atrophy, Spinal - physiopathology</topic><topic>Neuromuscular diseases</topic><topic>Spinal muscular atrophy</topic><topic>The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baranello, Giovanni</creatorcontrib><creatorcontrib>De Amicis, Ramona</creatorcontrib><creatorcontrib>Arnoldi, Maria Teresa</creatorcontrib><creatorcontrib>Zanin, Riccardo</creatorcontrib><creatorcontrib>Mastella, Chiara</creatorcontrib><creatorcontrib>Masson, Riccardo</creatorcontrib><creatorcontrib>Leone, Alessandro</creatorcontrib><creatorcontrib>Alberti, Katia</creatorcontrib><creatorcontrib>Foppiani, Andrea</creatorcontrib><creatorcontrib>Battezzati, Alberto</creatorcontrib><creatorcontrib>Bertoli, Simona</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baranello, Giovanni</au><au>De Amicis, Ramona</au><au>Arnoldi, Maria Teresa</au><au>Zanin, Riccardo</au><au>Mastella, Chiara</au><au>Masson, Riccardo</au><au>Leone, Alessandro</au><au>Alberti, Katia</au><au>Foppiani, Andrea</au><au>Battezzati, Alberto</au><au>Bertoli, Simona</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of body composition as a potential biomarker in spinal muscular atrophy</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-04</date><risdate>2020</risdate><volume>61</volume><issue>4</issue><spage>530</spage><epage>534</epage><pages>530-534</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Introduction
We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments.
Methods
Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII).
Results
Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.
Discussion
BC shows promise as a potential biomarker for SMA, but further studies are needed.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32012296</pmid><doi>10.1002/mus.26823</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Muscle & nerve, 2020-04, Vol.61 (4), p.530-534 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Absorptiometry, Photon Adipose Tissue - diagnostic imaging Adipose Tissue - physiopathology Anthropometry Assessments Atrophy Biomarkers Body composition Body Composition - physiology Body fat Body mass Body mass index Body size Child Child, Preschool Children Correlation Cross-Sectional Studies fat‐free mass Female Hammersmith Functional Motor Scale―Expanded Human motion Humans Infant Male Muscular Atrophy, Spinal - diagnosis Muscular Atrophy, Spinal - diagnostic imaging Muscular Atrophy, Spinal - physiopathology Neuromuscular diseases Spinal muscular atrophy The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders |
| title | Evaluation of body composition as a potential biomarker in spinal muscular atrophy |
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