Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe
We report an intracellular imaging and assay nanoplatform for RNase A using a DNA tetrahedron-based fluorescent probe as a substrate. Importantly, a natural compound was used as an RNase A activity stimulator to improve the sensitivity. This platform provides an alternative for the diagnosis and pro...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (21), p.3229-3232 |
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| container_end_page | 3232 |
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| container_issue | 21 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 56 |
| creator | Tong, Chunyi Hu, Yalei Xie, Qian Zhou, Ting Fan, Jialong Qin, Yan Liu, Bin Wang, Wei |
| description | We report an intracellular imaging and assay nanoplatform for RNase A using a DNA tetrahedron-based fluorescent probe as a substrate. Importantly, a natural compound was used as an RNase A activity stimulator to improve the sensitivity. This platform provides an alternative for the diagnosis and prognosis of RNase A-related diseases and drug screening.
We report an intracellular imaging and assay nanoplatform for RNase A using a DNA tetrahedron-based fluorescent probe as a substrate. |
| doi_str_mv | 10.1039/d0cc00284d |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-03, Vol.56 (21), p.3229-3232 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biological Products - chemistry DNA - chemistry Drug Evaluation, Preclinical Fluorescent Dyes - chemistry Fluorescent indicators Hep G2 Cells Humans Medical imaging Optical Imaging Ribonuclease, Pancreatic - analysis Ribonuclease, Pancreatic - metabolism Stimulators Substrates Tetrahedra |
| title | Sensitive RNase A detection and intracellular imaging using a natural compound-assisted tetrahedral DNA nanoprobe |
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