A pump‐free tricellular blood–brain barrier on‐a‐chip model to understand barrier property and evaluate drug response

Disruption of the blood–brain barrier (BBB) leads to various neurovascular diseases. Development of therapeutics required to cross the BBB is difficult due to a lack of relevant in vitro models. We have developed a three‐dimensional (3D) microfluidic BBB chip (BBBC) to study cell interactions in the...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-04, Vol.117 (4), p.1127-1136
Hauptverfasser:	Yu, Fang, Kumar, Nivasini D/O Selva, Foo, Lynette C., Ng, Sum Huan, Hunziker, Walter, Choudhury, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - metabolism Barrier layers Blood Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Brain - cytology cell culture Cell interactions Cells, Cultured Coculture Techniques - instrumentation Coculture Techniques - methods Collagen Collagen (type I) Computational fluid dynamics Dexamethasone Disruption Drug delivery Drug development Drug Evaluation, Preclinical - instrumentation drug screening Endothelial cells Equipment Design Fluid flow Glucocorticoids Hydrogels In vivo methods and tests Inflammation Inflammation - metabolism Lab-On-A-Chip Devices Microchannels Microfluidic Analytical Techniques - instrumentation Microfluidics Microvasculature Neonates organ‐on‐a‐chip Patterning Pericytes Pericytes - cytology Pericytes - drug effects Pericytes - metabolism Rats Rats, Sprague-Dawley Tumor necrosis factor-α
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