An Insight into the Mechanisms of the Phototoxic Response Induced by Cyamemazine in Cultured Fibroblasts and Keratinocytes

The phototoxicity of cyamemazine (CMZ, Tercian®), a neuroleptic of the phenothiazine family, has recently been reported in humans. CMZ has an absorbance maximum at 267 nm (molar absorptivity, 25 800 M−1 cm−1) but a weaker molar absorptivity in the ultraviolet A (UV-A) region. CMZ exhibits a fluoresc...

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Veröffentlicht in:	Photochemistry and photobiology 2004-02, Vol.79 (2), p.163-171
Hauptverfasser:	Morlière, Patrice, Haigle, Josiane, Aissani, Karim, Filipe, Paulo, Silva, João Nuno, Santus, René
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Death Cells, Cultured Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Fibroblasts - drug effects Fibroblasts - metabolism Humans Intracellular Membranes - drug effects Intracellular Membranes - metabolism Keratinocytes - drug effects Keratinocytes - metabolism Lipid Peroxidation - drug effects Lysosomes - drug effects Lysosomes - metabolism Microscopy, Phase-Contrast Phenothiazines - analysis Phenothiazines - toxicity Photosensitizing Agents - toxicity Research s Spectrometry, Fluorescence Ultraviolet Rays
Online-Zugang:	Volltext
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