Cyclooxygenase-2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches

Inflammatory stimuli result in the production of cutaneous eicosanoids, which are known to contribute to the process of tumor promotion. Cyclooxygenase (COX), the rate-limiting enzyme for the production of prostaglandins (PG) from arachidonic acid, exists in at least two isoforms, COX-1 and COX-2. C...

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Veröffentlicht in:	Photochemistry and photobiology 2002-07, Vol.76 (1), p.73-80
Hauptverfasser:	An, Kathy P., Athar, Mohammad, Tang, Xiuwei, Katiyar, Santosh K., Russo, Justin, Beech, J., Aszterbaum, Michelle, Kopelovich, Levy, Epstein, Ervin H., Mukhtar, Hasan, Bickers, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - therapeutic use Female Humans Isoenzymes - metabolism Male Membrane Proteins Mice Mice, Hairless Mice, Inbred C57BL Mice, Inbred DBA Mice, Mutant Strains Middle Aged Neoplasms, Radiation-Induced - drug therapy Neoplasms, Radiation-Induced - enzymology PHOTOMEDICINE Prostaglandin-Endoperoxide Synthases - metabolism Skin - enzymology Skin - radiation effects Skin Neoplasms - drug therapy Skin Neoplasms - enzymology Ultraviolet Rays - adverse effects
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