Rat liver and kidney post-mitochondrial dysfunction by addition of chronic mixed metal intoxication and hepatorenal wellness mediated by phenolic components from Croton zambiscus leaves

•Chronic exposure to EOMABRSL increased the markers of liver toxicity and kidney failure•Chronic exposure to mixture of environmental toxicants decreased the key markers of hepatorenal ATP•Phenolic antioxidants from Croton zambiscus leaves promoted hepatorenal wellness. Chronic exposure of mixed-met...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2020-02, Vol.74, p.103293, Article 103293
Hauptverfasser:	Akintunde, J.K, Ayeni, S.A, Adeoye, M.A, Shittu, A.O
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Bilirubin Chronic exposure Coalescing Creatinine Croton Damage Degeneration Electrolytes Electrolytic cells Epithelial cells Exposure Fraction Hepatocytes Hepatorenal Intoxication Kidneys L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Liver Liver diseases Metals Mitochondria Mixed-metal intoxication Necrosis Nucleotidase Oral administration Oxidative stress Phenolic antioxidant Phenolic compounds Phenols Renal failure Sheaths Spleen Splenocytes Toxicity Urea Uric acid zambesicus
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