Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome
Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS). Methods: Peripheral blo...
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| Veröffentlicht in: | Experimental Biomedical Research 2019-01, Vol.2 (1), p.8-19 |
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| creator | Celik, Faruk Kucukhuseyin, Ozlem Duran, Bulent Diramali, Murat Zeybek, Sakir Umit Duzenli, Selma Yaylim, Ilhan Arslan, Ali Osman |
| description | Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS). Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected, Polymorphisms in related genes was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, the related biochemical values of the patients were also investigated. Result: In our study there is no significant results for SOD2 gene but the results obtained between GPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waist circumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with the disease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing the disease. Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CAT enzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride, insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in the presence of homozygous mutation. Keywords: Polycystic ovarian syndrome, antioxidant enzyme genes, polymorphisms. |
| doi_str_mv | 10.30714/j-ebr.2019147578 |
| format | Article |
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Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected, Polymorphisms in related genes was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, the related biochemical values of the patients were also investigated. Result: In our study there is no significant results for SOD2 gene but the results obtained between GPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waist circumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with the disease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing the disease. Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CAT enzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride, insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in the presence of homozygous mutation. Keywords: Polycystic ovarian syndrome, antioxidant enzyme genes, polymorphisms.</description><identifier>ISSN: 2618-6454</identifier><identifier>EISSN: 2618-6454</identifier><identifier>DOI: 10.30714/j-ebr.2019147578</identifier><language>eng</language><publisher>Bolu: Hayrettin Ozturk</publisher><subject>Animal genetics ; Antioxidants ; Blood sugar ; Care and treatment ; Catalase ; Dehydroepiandrosterone ; Endothelium ; Enzymes ; Ethylenediaminetetraacetic acid ; Follicle-stimulating hormone ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic research ; Glutathione peroxidase ; Hormones, Sex ; Insulin ; Investigations ; Medical research ; Medicine, Experimental ; Nitric-oxide synthase ; Peripheral blood ; Polycystic ovary syndrome ; Polymerase chain reaction ; Restriction fragment length polymorphism ; Sağlık Hizmetleri ; Stein-Leventhal syndrome ; Superoxide dismutase ; Tıp</subject><ispartof>Experimental Biomedical Research, 2019-01, Vol.2 (1), p.8-19</ispartof><rights>COPYRIGHT 2019 Hayrettin Ozturk</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2608-234ed13b104ad5abe7e3eb4462308aee207b98782c1497d11d9e25bef5d2f1db3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><contributor>Öztürk,Hayrettin</contributor><creatorcontrib>Celik, Faruk</creatorcontrib><creatorcontrib>Kucukhuseyin, Ozlem</creatorcontrib><creatorcontrib>Duran, Bulent</creatorcontrib><creatorcontrib>Diramali, Murat</creatorcontrib><creatorcontrib>Zeybek, Sakir Umit</creatorcontrib><creatorcontrib>Duzenli, Selma</creatorcontrib><creatorcontrib>Yaylim, Ilhan</creatorcontrib><creatorcontrib>Arslan, Ali Osman</creatorcontrib><title>Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome</title><title>Experimental Biomedical Research</title><description>Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS). Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected, Polymorphisms in related genes was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, the related biochemical values of the patients were also investigated. Result: In our study there is no significant results for SOD2 gene but the results obtained between GPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waist circumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with the disease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing the disease. Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CAT enzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride, insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in the presence of homozygous mutation. Keywords: Polycystic ovarian syndrome, antioxidant enzyme genes, polymorphisms.</description><subject>Animal genetics</subject><subject>Antioxidants</subject><subject>Blood sugar</subject><subject>Care and treatment</subject><subject>Catalase</subject><subject>Dehydroepiandrosterone</subject><subject>Endothelium</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Follicle-stimulating hormone</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic research</subject><subject>Glutathione peroxidase</subject><subject>Hormones, Sex</subject><subject>Insulin</subject><subject>Investigations</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nitric-oxide synthase</subject><subject>Peripheral blood</subject><subject>Polycystic ovary syndrome</subject><subject>Polymerase chain reaction</subject><subject>Restriction fragment length polymorphism</subject><subject>Sağlık Hizmetleri</subject><subject>Stein-Leventhal syndrome</subject><subject>Superoxide dismutase</subject><subject>Tıp</subject><issn>2618-6454</issn><issn>2618-6454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpNUU2L2zAUNGULG7b5Ab0JeujJWX3Zko8hze4GAr20ZyFLz1kFW3IlJ13311dpClnEQ8PTzEh6UxSfCV4xLAh_PJbQxhXFpCFcVEJ-KBa0JrKsecXv3uH7YpnSEWNMpeCY4EVx2vkzpMkd9OSCR6FDZx2d9lO6YBPd5Izu-xm5YQxxygcolwtvzl4w-D_zAOgAHhJyHo3ZBi7i3256RWPoZzNnd4NCtp1Rmr2NYYBPxcdO9wmW__eH4ufT9sfmpdx_f95t1vvS0BrLkjIOlrCWYK5tpVsQwKDlvKYMSw1AsWgbKSQ1hDfCEmIboFULXWVpR2zLHoovV98xhl-n_E91DKfo85WKMkHy6HCDM-vrleUs6D743nm4EXfftuu9koyIC3N1ZR50D8r5LkxRm7wsDM4ED53L_XWdH8hZVcksIFeBiSGlCJ0aoxvyKBTB6l926qhyduqWHfsLi26PWA</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Celik, Faruk</creator><creator>Kucukhuseyin, Ozlem</creator><creator>Duran, Bulent</creator><creator>Diramali, Murat</creator><creator>Zeybek, Sakir Umit</creator><creator>Duzenli, Selma</creator><creator>Yaylim, Ilhan</creator><creator>Arslan, Ali Osman</creator><general>Hayrettin Ozturk</general><general>Prof. Dr. Hayrettin Öztürk</general><general>Experimental Biomedical Research</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190101</creationdate><title>Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome</title><author>Celik, Faruk ; Kucukhuseyin, Ozlem ; Duran, Bulent ; Diramali, Murat ; Zeybek, Sakir Umit ; Duzenli, Selma ; Yaylim, Ilhan ; Arslan, Ali Osman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2608-234ed13b104ad5abe7e3eb4462308aee207b98782c1497d11d9e25bef5d2f1db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal genetics</topic><topic>Antioxidants</topic><topic>Blood sugar</topic><topic>Care and treatment</topic><topic>Catalase</topic><topic>Dehydroepiandrosterone</topic><topic>Endothelium</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Follicle-stimulating hormone</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic research</topic><topic>Glutathione peroxidase</topic><topic>Hormones, Sex</topic><topic>Insulin</topic><topic>Investigations</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Nitric-oxide synthase</topic><topic>Peripheral blood</topic><topic>Polycystic ovary syndrome</topic><topic>Polymerase chain reaction</topic><topic>Restriction fragment length polymorphism</topic><topic>Sağlık Hizmetleri</topic><topic>Stein-Leventhal syndrome</topic><topic>Superoxide dismutase</topic><topic>Tıp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Celik, Faruk</creatorcontrib><creatorcontrib>Kucukhuseyin, Ozlem</creatorcontrib><creatorcontrib>Duran, Bulent</creatorcontrib><creatorcontrib>Diramali, Murat</creatorcontrib><creatorcontrib>Zeybek, Sakir Umit</creatorcontrib><creatorcontrib>Duzenli, Selma</creatorcontrib><creatorcontrib>Yaylim, Ilhan</creatorcontrib><creatorcontrib>Arslan, Ali Osman</creatorcontrib><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>Idealonline online kütüphane - Journals</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Experimental Biomedical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Celik, Faruk</au><au>Kucukhuseyin, Ozlem</au><au>Duran, Bulent</au><au>Diramali, Murat</au><au>Zeybek, Sakir Umit</au><au>Duzenli, Selma</au><au>Yaylim, Ilhan</au><au>Arslan, Ali Osman</au><au>Öztürk,Hayrettin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome</atitle><jtitle>Experimental Biomedical Research</jtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2</volume><issue>1</issue><spage>8</spage><epage>19</epage><pages>8-19</pages><issn>2618-6454</issn><eissn>2618-6454</eissn><abstract>Aim: To investigate the possible effects of polymorphisms in genes encoding some important antioxidant enzymes such as super oxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), endothelial NOS (eNOS) and catalase (CAT) in patients with polycystic ovary syndrome (PCOS). Methods: Peripheral blood of 100 patients with PCOS and 100 healthy control group were collected, Polymorphisms in related genes was investigated by using polymerase chain reaction-restriction fragment length polymorphism. In addition, the related biochemical values of the patients were also investigated. Result: In our study there is no significant results for SOD2 gene but the results obtained between GPX1, eNOS and CAT genes were significant. Fasting blood sugar (FBS), insulin, triglyceride, waist circumference and dehydroepiandrosterone sulphate (DHEAS) were found to be significant with the disease, whereas follicle-stimulating hormone (FSH) was found to be effective in preventing the disease. Conclusions: These findings suggest that polymorphisms in genes encoding GPX1, eNOS and CAT enzymes may be associated with PCOS. Additionally, it is thought that the genes of FBS, triglyceride, insulin, DHEAS and waist circumference are important in the pathogenesis of the disease in the presence of homozygous mutation. Keywords: Polycystic ovarian syndrome, antioxidant enzyme genes, polymorphisms.</abstract><cop>Bolu</cop><pub>Hayrettin Ozturk</pub><doi>10.30714/j-ebr.2019147578</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal genetics Antioxidants Blood sugar Care and treatment Catalase Dehydroepiandrosterone Endothelium Enzymes Ethylenediaminetetraacetic acid Follicle-stimulating hormone Gene polymorphism Genes Genetic aspects Genetic polymorphisms Genetic research Glutathione peroxidase Hormones, Sex Insulin Investigations Medical research Medicine, Experimental Nitric-oxide synthase Peripheral blood Polycystic ovary syndrome Polymerase chain reaction Restriction fragment length polymorphism Sağlık Hizmetleri Stein-Leventhal syndrome Superoxide dismutase Tıp |
| title | Investigation of variants of critically important antioxidant enzyme genes in patients with polycystic ovary syndrome |
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