Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process?
Sperm cryopreservation is a routine method in andrology and IVF laboratory. However, the sperm quality and its fertilizing capacity have been decreased during this process. The purpose of this experiment was to determine the role of myoinositol as a supplement in amelioration of total and progressiv...
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| Veröffentlicht in: | Cell and tissue banking 2020-03, Vol.21 (1), p.99-106 |
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| creator | Abdolsamadi, Mona Mohammadi, Fatemeh Nashtaei, Maryam Shabani Teimouri, Maryam Sardar, Reza Dayani, Maliheh Haghighi, Maryam Ghasemi, Samaneh Vatannejad, Akram Zandieh, Zahra |
| description | Sperm cryopreservation is a routine method in andrology and IVF laboratory. However, the sperm quality and its fertilizing capacity have been decreased during this process. The purpose of this experiment was to determine the role of myoinositol as a supplement in amelioration of total and progressive sperm motility, DNA fragmentation, total antioxidant capacity (TAC), reactive oxygen species (ROS), and lipid peroxidation after the freezing–thawing process on patients with oligoasthenoteratozoospermia (OAT) syndrome. Semen samples obtained from 40 patients were divided into two aliquots and freezed with simple and 2 mg/mL myoinositol (MYO) supplemented freezing media. All samples were thawed and assessed after one month. Semen parameters were analyzed in terms of the motility by CASA, the level of total ROS by fluorimetry, TAC and MDA by colorimetric assay and finally DNA fragmentation by TUNEL assay. Our results clearly showed that MYO could improve total (37.46 vs. 12.91,
p
|
| doi_str_mv | 10.1007/s10561-019-09801-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2371561385</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2371561385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-cbcd9455d6040c8599981a305168fb1a3995a693cbbaae5239379c1d924419413</originalsourceid><addsrcrecordid>eNp9UctO3DAUtVARr_YHuqgssQ614ziJVxXi1UoINu3acpKbGaNJnPp6QMOKf-iun9cv4TIzwK4rH_m8pHsY-yzFiRSi-opS6FJmQppMmFrIrNphB1JXKitrWXwgrGqTGaXUPjtEvBMiF1Wu9ti-knWhRZkfsL_nAZAPq-DHgD6FBcflNC1ggDFxP0wx3APHCeLAJxfdAAkicjd2_PzmlPsxwSz6tCJEfPLkQv7g05yHhZ8Fh2kOYyCPS-ExhHWQd9z19MWJ430EePTj7N_TnzR3D4Q4dbaA-O0j2-3dAuHT9j1ivy4vfp59z65vr36cnV5nrap0ytqm7UyhdVeKQrS1NsbU0imhZVn3DSFjtCuNapvGOdC5MqoyrexMXhTSFFIdseNNLhX_XgImexeWcaRKm6tK0olVrUmVb1RtDIgRejtFP7i4slLYlznsZg5Lc9j1HLYi05dt9LIZoHuzvN6fBGojQKLGGcT37v_EPgMl65py</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2371561385</pqid></control><display><type>article</type><title>Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process?</title><source>MEDLINE</source><source>SpringerLink</source><creator>Abdolsamadi, Mona ; Mohammadi, Fatemeh ; Nashtaei, Maryam Shabani ; Teimouri, Maryam ; Sardar, Reza ; Dayani, Maliheh ; Haghighi, Maryam ; Ghasemi, Samaneh ; Vatannejad, Akram ; Zandieh, Zahra</creator><creatorcontrib>Abdolsamadi, Mona ; Mohammadi, Fatemeh ; Nashtaei, Maryam Shabani ; Teimouri, Maryam ; Sardar, Reza ; Dayani, Maliheh ; Haghighi, Maryam ; Ghasemi, Samaneh ; Vatannejad, Akram ; Zandieh, Zahra</creatorcontrib><description>Sperm cryopreservation is a routine method in andrology and IVF laboratory. However, the sperm quality and its fertilizing capacity have been decreased during this process. The purpose of this experiment was to determine the role of myoinositol as a supplement in amelioration of total and progressive sperm motility, DNA fragmentation, total antioxidant capacity (TAC), reactive oxygen species (ROS), and lipid peroxidation after the freezing–thawing process on patients with oligoasthenoteratozoospermia (OAT) syndrome. Semen samples obtained from 40 patients were divided into two aliquots and freezed with simple and 2 mg/mL myoinositol (MYO) supplemented freezing media. All samples were thawed and assessed after one month. Semen parameters were analyzed in terms of the motility by CASA, the level of total ROS by fluorimetry, TAC and MDA by colorimetric assay and finally DNA fragmentation by TUNEL assay. Our results clearly showed that MYO could improve total (37.46 vs. 12.91,
p
< 0.001) and progressive motility (21.92 vs. 6.49,
p
< 0.001) in experimental group compared to control group. A higher TAC level was observed in the MYO treated group in comparison to control group (1.11 vs. 0.91,
p
= 0.05). While MYO supplementation could not be effective on ROS level, it reduced DNA fragmentation of sperm after freeze–thaw process (
p
= 0.01). Therefore, MYO could be a good supplement for sperm freezing to reduce the detrimental effects of freezing process especially on DNA integrity, which is an important factor in the success of ART, in OAT suffered patients.</description><identifier>ISSN: 1389-9333</identifier><identifier>EISSN: 1573-6814</identifier><identifier>DOI: 10.1007/s10561-019-09801-7</identifier><identifier>PMID: 31845062</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Antioxidants ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Colorimetry ; Cryopreservation ; Cryopreservation - methods ; Cryoprotective Agents - pharmacology ; Deoxyribonucleic acid ; DNA ; DNA fragmentation ; DNA Fragmentation - drug effects ; Freeze-thawing ; Freezing ; Full Length Paper ; Humans ; Inositol - pharmacology ; Life Sciences ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Male ; Middle Aged ; Motility ; Oligoasthenoteratozoospermia ; Oligospermia - metabolism ; Oxidative stress ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Semen ; Semen Preservation - methods ; Sperm ; Sperm Motility - drug effects ; Spermatozoa - cytology ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Supplements ; Thawing ; Transplant Surgery</subject><ispartof>Cell and tissue banking, 2020-03, Vol.21 (1), p.99-106</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Cell and Tissue Banking is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cbcd9455d6040c8599981a305168fb1a3995a693cbbaae5239379c1d924419413</citedby><cites>FETCH-LOGICAL-c375t-cbcd9455d6040c8599981a305168fb1a3995a693cbbaae5239379c1d924419413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10561-019-09801-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10561-019-09801-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31845062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdolsamadi, Mona</creatorcontrib><creatorcontrib>Mohammadi, Fatemeh</creatorcontrib><creatorcontrib>Nashtaei, Maryam Shabani</creatorcontrib><creatorcontrib>Teimouri, Maryam</creatorcontrib><creatorcontrib>Sardar, Reza</creatorcontrib><creatorcontrib>Dayani, Maliheh</creatorcontrib><creatorcontrib>Haghighi, Maryam</creatorcontrib><creatorcontrib>Ghasemi, Samaneh</creatorcontrib><creatorcontrib>Vatannejad, Akram</creatorcontrib><creatorcontrib>Zandieh, Zahra</creatorcontrib><title>Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process?</title><title>Cell and tissue banking</title><addtitle>Cell Tissue Bank</addtitle><addtitle>Cell Tissue Bank</addtitle><description>Sperm cryopreservation is a routine method in andrology and IVF laboratory. However, the sperm quality and its fertilizing capacity have been decreased during this process. The purpose of this experiment was to determine the role of myoinositol as a supplement in amelioration of total and progressive sperm motility, DNA fragmentation, total antioxidant capacity (TAC), reactive oxygen species (ROS), and lipid peroxidation after the freezing–thawing process on patients with oligoasthenoteratozoospermia (OAT) syndrome. Semen samples obtained from 40 patients were divided into two aliquots and freezed with simple and 2 mg/mL myoinositol (MYO) supplemented freezing media. All samples were thawed and assessed after one month. Semen parameters were analyzed in terms of the motility by CASA, the level of total ROS by fluorimetry, TAC and MDA by colorimetric assay and finally DNA fragmentation by TUNEL assay. Our results clearly showed that MYO could improve total (37.46 vs. 12.91,
p
< 0.001) and progressive motility (21.92 vs. 6.49,
p
< 0.001) in experimental group compared to control group. A higher TAC level was observed in the MYO treated group in comparison to control group (1.11 vs. 0.91,
p
= 0.05). While MYO supplementation could not be effective on ROS level, it reduced DNA fragmentation of sperm after freeze–thaw process (
p
= 0.01). Therefore, MYO could be a good supplement for sperm freezing to reduce the detrimental effects of freezing process especially on DNA integrity, which is an important factor in the success of ART, in OAT suffered patients.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Colorimetry</subject><subject>Cryopreservation</subject><subject>Cryopreservation - methods</subject><subject>Cryoprotective Agents - pharmacology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA fragmentation</subject><subject>DNA Fragmentation - drug effects</subject><subject>Freeze-thawing</subject><subject>Freezing</subject><subject>Full Length Paper</subject><subject>Humans</subject><subject>Inositol - pharmacology</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motility</subject><subject>Oligoasthenoteratozoospermia</subject><subject>Oligospermia - metabolism</subject><subject>Oxidative stress</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Semen</subject><subject>Semen Preservation - methods</subject><subject>Sperm</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatozoa - cytology</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>Supplements</subject><subject>Thawing</subject><subject>Transplant 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DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process?</title><author>Abdolsamadi, Mona ; Mohammadi, Fatemeh ; Nashtaei, Maryam Shabani ; Teimouri, Maryam ; Sardar, Reza ; Dayani, Maliheh ; Haghighi, Maryam ; Ghasemi, Samaneh ; Vatannejad, Akram ; Zandieh, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cbcd9455d6040c8599981a305168fb1a3995a693cbbaae5239379c1d924419413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Colorimetry</topic><topic>Cryopreservation</topic><topic>Cryopreservation - methods</topic><topic>Cryoprotective Agents - pharmacology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA fragmentation</topic><topic>DNA Fragmentation - drug effects</topic><topic>Freeze-thawing</topic><topic>Freezing</topic><topic>Full Length Paper</topic><topic>Humans</topic><topic>Inositol - pharmacology</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motility</topic><topic>Oligoasthenoteratozoospermia</topic><topic>Oligospermia - metabolism</topic><topic>Oxidative stress</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Semen</topic><topic>Semen Preservation - methods</topic><topic>Sperm</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatozoa - cytology</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>Supplements</topic><topic>Thawing</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdolsamadi, Mona</creatorcontrib><creatorcontrib>Mohammadi, Fatemeh</creatorcontrib><creatorcontrib>Nashtaei, Maryam Shabani</creatorcontrib><creatorcontrib>Teimouri, Maryam</creatorcontrib><creatorcontrib>Sardar, Reza</creatorcontrib><creatorcontrib>Dayani, Maliheh</creatorcontrib><creatorcontrib>Haghighi, Maryam</creatorcontrib><creatorcontrib>Ghasemi, Samaneh</creatorcontrib><creatorcontrib>Vatannejad, Akram</creatorcontrib><creatorcontrib>Zandieh, Zahra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 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banking</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdolsamadi, Mona</au><au>Mohammadi, Fatemeh</au><au>Nashtaei, Maryam Shabani</au><au>Teimouri, Maryam</au><au>Sardar, Reza</au><au>Dayani, Maliheh</au><au>Haghighi, Maryam</au><au>Ghasemi, Samaneh</au><au>Vatannejad, Akram</au><au>Zandieh, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process?</atitle><jtitle>Cell and tissue banking</jtitle><stitle>Cell Tissue Bank</stitle><addtitle>Cell Tissue Bank</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>21</volume><issue>1</issue><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>1389-9333</issn><eissn>1573-6814</eissn><abstract>Sperm cryopreservation is a routine method in andrology and IVF laboratory. However, the sperm quality and its fertilizing capacity have been decreased during this process. The purpose of this experiment was to determine the role of myoinositol as a supplement in amelioration of total and progressive sperm motility, DNA fragmentation, total antioxidant capacity (TAC), reactive oxygen species (ROS), and lipid peroxidation after the freezing–thawing process on patients with oligoasthenoteratozoospermia (OAT) syndrome. Semen samples obtained from 40 patients were divided into two aliquots and freezed with simple and 2 mg/mL myoinositol (MYO) supplemented freezing media. All samples were thawed and assessed after one month. Semen parameters were analyzed in terms of the motility by CASA, the level of total ROS by fluorimetry, TAC and MDA by colorimetric assay and finally DNA fragmentation by TUNEL assay. Our results clearly showed that MYO could improve total (37.46 vs. 12.91,
p
< 0.001) and progressive motility (21.92 vs. 6.49,
p
< 0.001) in experimental group compared to control group. A higher TAC level was observed in the MYO treated group in comparison to control group (1.11 vs. 0.91,
p
= 0.05). While MYO supplementation could not be effective on ROS level, it reduced DNA fragmentation of sperm after freeze–thaw process (
p
= 0.01). Therefore, MYO could be a good supplement for sperm freezing to reduce the detrimental effects of freezing process especially on DNA integrity, which is an important factor in the success of ART, in OAT suffered patients.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31845062</pmid><doi>10.1007/s10561-019-09801-7</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Antioxidants Biomedical and Life Sciences Biomedicine Cell Biology Colorimetry Cryopreservation Cryopreservation - methods Cryoprotective Agents - pharmacology Deoxyribonucleic acid DNA DNA fragmentation DNA Fragmentation - drug effects Freeze-thawing Freezing Full Length Paper Humans Inositol - pharmacology Life Sciences Lipid peroxidation Lipid Peroxidation - drug effects Male Middle Aged Motility Oligoasthenoteratozoospermia Oligospermia - metabolism Oxidative stress Reactive oxygen species Reactive Oxygen Species - metabolism Semen Semen Preservation - methods Sperm Sperm Motility - drug effects Spermatozoa - cytology Spermatozoa - drug effects Spermatozoa - metabolism Supplements Thawing Transplant Surgery |
| title | Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process? |
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