TGF‐β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro

Nickel oxide nanoparticles (Nano NiO) bears hepatotoxicity, while whether it leads to liver fibrosis remains unclear. The aim of this study was to establish the Nano NiO‐induced hepatic fibrosis model in vivo and investigate the roles of transforming growth factor β1 (TGF‐β1) in Smad pathway activat...

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Veröffentlicht in:	Environmental toxicology 2020-04, Vol.35 (4), p.419-429
Hauptverfasser:	Zhang, Qiong, Chang, Xuhong, Wang, Haibing, Liu, Yunlan, Wang, Xiaoxia, Wu, Minmin, Zhan, Haibing, Li, Sheng, Sun, Yingbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Activation Animal models Animals Cells Collagen Collagen (type I) Collagen Type I - metabolism Deposition ECM deposition EMT Epithelial-Mesenchymal Transition - drug effects Extracellular Extracellular matrix Fibrosis Gelatinase B Growth factors Hep G2 Cells hepatic fibrosis Hepatocytes Hepatotoxicity Humans In vivo methods and tests Kinases Liver Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mesenchyme Muscles Nanoparticles Nanoparticles - chemistry Nickel Nickel - chemistry Nickel - toxicity nickel oxide nanoparticles Nickel oxides Proteins Rats Rats, Wistar Signal Transduction Smad pathway Smad protein Smad Proteins - metabolism Smad2 protein Smad3 protein Smad7 protein Smooth muscle TGF‐β1 Tissue inhibitor of metalloproteinase 1 Trachea Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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