Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase
Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coa...
Gespeichert in:
| Veröffentlicht in: | American journal of nephrology 2005-09, Vol.25 (5), p.500-506 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 506 |
|---|---|
| container_issue | 5 |
| container_start_page | 500 |
| container_title | American journal of nephrology |
| container_volume | 25 |
| creator | Akiyama, Shinichiro Inagaki, Masahiro Tsuji, Mayumi Gotoh, Hiromichi Gotoh, Tomomi Washio, Kazunori Gotoh, Yoshikazu Oguchi, Katsuji |
| description | Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coating of a dialyzer (VE-BMD) by measuring increased Cu/Zn-SOD in hemodialysis patients. Methods: 31 hemodialysis patients were divided into two groups: 16 hemodialysis patients underwent usual dialysis with vitamin E supplementation 600 mg/day while 15 others were dialyzed using vitamin E-coated membrane for 6 months. Total plasma SOD activity was determined by NBT method, plasma Cu/Zn-SOD contents by ELISA and Cu/Zn-SOD mRNA in leukocytes by RT-PCR. Results: VE-PO and VE-BMD showed almost comparable effects on Cu/Zn-SOD contents and its mRNA levels in hemodialysis patients. VE-PO resulted in a progressive decrease of Cu/Zn-SOD content (p < 0.001). A comparable progressive decrease was observed also in VE-BMD (p < 0.0001). Both VE-PO and VE-BMD resulted in a progressive decrease of Cu/Zn-SOD mRNA (p < 0.01), which reached the level of non-dialyzed CRF patients. |
| doi_str_mv | 10.1159/000088172 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_236961668</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68669597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-4bb400d69fdf5a6bc347066b033e37db379b47ffad65ac658072b580b174ea453</originalsourceid><addsrcrecordid>eNpd0Ulr3DAUAGBRGppp0kPPhWICDeTgRLIsyToWd7JAIIcsh17M01aU2tZUssny66thhgxEB0mH7y3SQ-grwaeEMHmG82oaIqoPaEHqipSSC_wRLXDFcNlgyfbR55QeMSZVg8UntE84YYwyuUBPbRhWEH0KYxFcsXTO6ml9e_ATDH4slmUbYLKm-OWhf3m1sYDRFDcR-h0pcvClHYJZk-RTeTWaWeeYdj77PZa388rG8OyNzUnSME-Q7CHac9An-2V7HqD78-Vde1le31xctT-vS11XfCprpWqMDZfOOAZcaVoLzLnClFoqjKJCqlo4B4Yz0Jzl51Uq74qI2kLN6AE63uRdxfBvtmnqBp-07XsYbZhTxxvOJZMiw6N38DHMccy9dRXlkhPOm4xONkjHkFK0rltFP0B86Qju1qPo3kaR7fdtwlkN1uzk9u8z-LEFkDT0LsKofdo5QQTNVbP7tnF_If6x8Q1syvwHtuiYOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>236961668</pqid></control><display><type>article</type><title>Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase</title><source>MEDLINE</source><source>Karger Journals</source><creator>Akiyama, Shinichiro ; Inagaki, Masahiro ; Tsuji, Mayumi ; Gotoh, Hiromichi ; Gotoh, Tomomi ; Washio, Kazunori ; Gotoh, Yoshikazu ; Oguchi, Katsuji</creator><creatorcontrib>Akiyama, Shinichiro ; Inagaki, Masahiro ; Tsuji, Mayumi ; Gotoh, Hiromichi ; Gotoh, Tomomi ; Washio, Kazunori ; Gotoh, Yoshikazu ; Oguchi, Katsuji</creatorcontrib><description>Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coating of a dialyzer (VE-BMD) by measuring increased Cu/Zn-SOD in hemodialysis patients. Methods: 31 hemodialysis patients were divided into two groups: 16 hemodialysis patients underwent usual dialysis with vitamin E supplementation 600 mg/day while 15 others were dialyzed using vitamin E-coated membrane for 6 months. Total plasma SOD activity was determined by NBT method, plasma Cu/Zn-SOD contents by ELISA and Cu/Zn-SOD mRNA in leukocytes by RT-PCR. Results: VE-PO and VE-BMD showed almost comparable effects on Cu/Zn-SOD contents and its mRNA levels in hemodialysis patients. VE-PO resulted in a progressive decrease of Cu/Zn-SOD content (p < 0.001). A comparable progressive decrease was observed also in VE-BMD (p < 0.0001). Both VE-PO and VE-BMD resulted in a progressive decrease of Cu/Zn-SOD mRNA (p < 0.01), which reached the level of non-dialyzed CRF patients.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000088172</identifier><identifier>PMID: 16155359</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Administration, Oral ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antioxidants - administration & dosage ; Antioxidants - therapeutic use ; Biological and medical sciences ; Coated Materials, Biocompatible ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - therapy ; Leukocytes - metabolism ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Original Report: Patient-Oriented, Translational Research ; Renal Dialysis - instrumentation ; RNA, Messenger - blood ; Superoxide Dismutase - blood ; Superoxide Dismutase - genetics ; Vitamin E - administration & dosage ; Vitamin E - therapeutic use</subject><ispartof>American journal of nephrology, 2005-09, Vol.25 (5), p.500-506</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>2005 INIST-CNRS</rights><rights>Copyright (c) 2005 S. Karger AG, Basel.</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-4bb400d69fdf5a6bc347066b033e37db379b47ffad65ac658072b580b174ea453</citedby><cites>FETCH-LOGICAL-c426t-4bb400d69fdf5a6bc347066b033e37db379b47ffad65ac658072b580b174ea453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17173166$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16155359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akiyama, Shinichiro</creatorcontrib><creatorcontrib>Inagaki, Masahiro</creatorcontrib><creatorcontrib>Tsuji, Mayumi</creatorcontrib><creatorcontrib>Gotoh, Hiromichi</creatorcontrib><creatorcontrib>Gotoh, Tomomi</creatorcontrib><creatorcontrib>Washio, Kazunori</creatorcontrib><creatorcontrib>Gotoh, Yoshikazu</creatorcontrib><creatorcontrib>Oguchi, Katsuji</creatorcontrib><title>Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coating of a dialyzer (VE-BMD) by measuring increased Cu/Zn-SOD in hemodialysis patients. Methods: 31 hemodialysis patients were divided into two groups: 16 hemodialysis patients underwent usual dialysis with vitamin E supplementation 600 mg/day while 15 others were dialyzed using vitamin E-coated membrane for 6 months. Total plasma SOD activity was determined by NBT method, plasma Cu/Zn-SOD contents by ELISA and Cu/Zn-SOD mRNA in leukocytes by RT-PCR. Results: VE-PO and VE-BMD showed almost comparable effects on Cu/Zn-SOD contents and its mRNA levels in hemodialysis patients. VE-PO resulted in a progressive decrease of Cu/Zn-SOD content (p < 0.001). A comparable progressive decrease was observed also in VE-BMD (p < 0.0001). Both VE-PO and VE-BMD resulted in a progressive decrease of Cu/Zn-SOD mRNA (p < 0.01), which reached the level of non-dialyzed CRF patients.</description><subject>Administration, Oral</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Coated Materials, Biocompatible</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Original Report: Patient-Oriented, Translational Research</subject><subject>Renal Dialysis - instrumentation</subject><subject>RNA, Messenger - blood</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - genetics</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - therapeutic use</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0Ulr3DAUAGBRGppp0kPPhWICDeTgRLIsyToWd7JAIIcsh17M01aU2tZUssny66thhgxEB0mH7y3SQ-grwaeEMHmG82oaIqoPaEHqipSSC_wRLXDFcNlgyfbR55QeMSZVg8UntE84YYwyuUBPbRhWEH0KYxFcsXTO6ml9e_ATDH4slmUbYLKm-OWhf3m1sYDRFDcR-h0pcvClHYJZk-RTeTWaWeeYdj77PZa388rG8OyNzUnSME-Q7CHac9An-2V7HqD78-Vde1le31xctT-vS11XfCprpWqMDZfOOAZcaVoLzLnClFoqjKJCqlo4B4Yz0Jzl51Uq74qI2kLN6AE63uRdxfBvtmnqBp-07XsYbZhTxxvOJZMiw6N38DHMccy9dRXlkhPOm4xONkjHkFK0rltFP0B86Qju1qPo3kaR7fdtwlkN1uzk9u8z-LEFkDT0LsKofdo5QQTNVbP7tnF_If6x8Q1syvwHtuiYOQ</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Akiyama, Shinichiro</creator><creator>Inagaki, Masahiro</creator><creator>Tsuji, Mayumi</creator><creator>Gotoh, Hiromichi</creator><creator>Gotoh, Tomomi</creator><creator>Washio, Kazunori</creator><creator>Gotoh, Yoshikazu</creator><creator>Oguchi, Katsuji</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase</title><author>Akiyama, Shinichiro ; Inagaki, Masahiro ; Tsuji, Mayumi ; Gotoh, Hiromichi ; Gotoh, Tomomi ; Washio, Kazunori ; Gotoh, Yoshikazu ; Oguchi, Katsuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-4bb400d69fdf5a6bc347066b033e37db379b47ffad65ac658072b580b174ea453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Oral</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Coated Materials, Biocompatible</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Original Report: Patient-Oriented, Translational Research</topic><topic>Renal Dialysis - instrumentation</topic><topic>RNA, Messenger - blood</topic><topic>Superoxide Dismutase - blood</topic><topic>Superoxide Dismutase - genetics</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akiyama, Shinichiro</creatorcontrib><creatorcontrib>Inagaki, Masahiro</creatorcontrib><creatorcontrib>Tsuji, Mayumi</creatorcontrib><creatorcontrib>Gotoh, Hiromichi</creatorcontrib><creatorcontrib>Gotoh, Tomomi</creatorcontrib><creatorcontrib>Washio, Kazunori</creatorcontrib><creatorcontrib>Gotoh, Yoshikazu</creatorcontrib><creatorcontrib>Oguchi, Katsuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akiyama, Shinichiro</au><au>Inagaki, Masahiro</au><au>Tsuji, Mayumi</au><au>Gotoh, Hiromichi</au><au>Gotoh, Tomomi</au><au>Washio, Kazunori</au><au>Gotoh, Yoshikazu</au><au>Oguchi, Katsuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2005-09</date><risdate>2005</risdate><volume>25</volume><issue>5</issue><spage>500</spage><epage>506</epage><pages>500-506</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Background: We reported earlier that production of Cu/Zn-superoxide dismutase (SOD) increases markedly in hemodialysis patients but not in non-dialyzed chronic renal failure (CRF) patients. In this study, we compared the antioxidant effects of oral vitamin E supplementation (VE-PO) and vitamin E coating of a dialyzer (VE-BMD) by measuring increased Cu/Zn-SOD in hemodialysis patients. Methods: 31 hemodialysis patients were divided into two groups: 16 hemodialysis patients underwent usual dialysis with vitamin E supplementation 600 mg/day while 15 others were dialyzed using vitamin E-coated membrane for 6 months. Total plasma SOD activity was determined by NBT method, plasma Cu/Zn-SOD contents by ELISA and Cu/Zn-SOD mRNA in leukocytes by RT-PCR. Results: VE-PO and VE-BMD showed almost comparable effects on Cu/Zn-SOD contents and its mRNA levels in hemodialysis patients. VE-PO resulted in a progressive decrease of Cu/Zn-SOD content (p < 0.001). A comparable progressive decrease was observed also in VE-BMD (p < 0.0001). Both VE-PO and VE-BMD resulted in a progressive decrease of Cu/Zn-SOD mRNA (p < 0.01), which reached the level of non-dialyzed CRF patients.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16155359</pmid><doi>10.1159/000088172</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-8095 |
| ispartof | American journal of nephrology, 2005-09, Vol.25 (5), p.500-506 |
| issn | 0250-8095 1421-9670 |
| language | eng |
| recordid | cdi_proquest_journals_236961668 |
| source | MEDLINE; Karger Journals |
| subjects | Administration, Oral Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antioxidants - administration & dosage Antioxidants - therapeutic use Biological and medical sciences Coated Materials, Biocompatible Emergency and intensive care: renal failure. Dialysis management Female Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Leukocytes - metabolism Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Original Report: Patient-Oriented, Translational Research Renal Dialysis - instrumentation RNA, Messenger - blood Superoxide Dismutase - blood Superoxide Dismutase - genetics Vitamin E - administration & dosage Vitamin E - therapeutic use |
| title | Comparison of Effect of Vitamin E-Coated Dialyzer and Oral Vitamin E on Hemodialysis-Induced Cu/Zn-Superoxide Dismutase |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T13%3A13%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Effect%20of%20Vitamin%20E-Coated%20Dialyzer%20and%20Oral%20Vitamin%20E%20on%20Hemodialysis-Induced%20Cu/Zn-Superoxide%20Dismutase&rft.jtitle=American%20journal%20of%20nephrology&rft.au=Akiyama,%20Shinichiro&rft.date=2005-09&rft.volume=25&rft.issue=5&rft.spage=500&rft.epage=506&rft.pages=500-506&rft.issn=0250-8095&rft.eissn=1421-9670&rft.coden=AJNED9&rft_id=info:doi/10.1159/000088172&rft_dat=%3Cproquest_cross%3E68669597%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=236961668&rft_id=info:pmid/16155359&rfr_iscdi=true |