Isoflurane-induced expression of miR-140-5p aggravates neurotoxicity in diabetic rats by targeting SNX12

MicroRNAs (miRNAs) are widely known as critical regulators in isoflurane-induced neurotoxicity during the development of brain. Moreover, isoflurane could aggravate cognitive impairment in diabetic rats. The present study was designed to investigate the role and mechanism of miR-140-5p on isoflurane...

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Veröffentlicht in:	Journal of toxicological sciences 2020, Vol.45(2), pp.69-76
Hauptverfasser:	Fan, Dongyi, Yang, Simin, Han, Yuxiang, Zhang, Ru, Yang, Lukun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cognitive ability Cognitive impairment Diabetes Diabetes mellitus Impairment Isoflurane Latency miR-140-5p miRNA Mitigation Neuroprotection Neurotoxicity Nexin Regulators Rodents SNX12 Streptozocin Streptozotocin
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