Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients
Background: Hepatitis C virus (HCV) is a major cause of hepatitis in hemodialysis (HD) patients. Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological...
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| Veröffentlicht in: | American journal of nephrology 2000-03, Vol.20 (2), p.103-106 |
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| creator | Alfurayh, O. Sabeel, A. Al Ahdal, M.N. Almeshari, K. Kessie, G. Hamid, M. Dela Cruz, D.M. |
| description | Background: Hepatitis C virus (HCV) is a major cause of hepatitis in hemodialysis (HD) patients. Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological study in our HD unit to investigate if the hands of dialysis personnel could represent a mode of transmission of HCV among HD patients. Methods: One liter of sterile water was used for each handwashing of dialysis personnel. The washing was collected in a sterile container and tested for HCV-RNA by polymerase chain reaction (PCR) within 3 h of collection. Eighty handwashings from nurses dialyzing HCV-positive patients (groupe A) and 100 handwashing from nurses dialyzing HCV-negative patients (group B) were tested for HCV-RNA. As a control, 60 handwashings were collected from the dialysis personnel before entering the dialysis unit (group C) and tested for HCV-RNA. Results: HCV-RNA was positive in 19 (23.75%) of samples of group A, in 8 (8%) of samples of group B (p < 0.003) and in 2 (3.3%) of samples of group C (p < 0.35). These two positive samples of group C were from nurses who had dialyzed HCV-negative patients. Conclusion: These results indicate the presence of HCV-RNA on the hands of some dialysis personnel in our HD unit, in spite fo adherence to the standard precautions. The hands of dialysis personnel are therefore a potential mode for facilitating transmission of HCV between HD patients. |
| doi_str_mv | 10.1159/000013565 |
| format | Article |
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Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological study in our HD unit to investigate if the hands of dialysis personnel could represent a mode of transmission of HCV among HD patients. Methods: One liter of sterile water was used for each handwashing of dialysis personnel. The washing was collected in a sterile container and tested for HCV-RNA by polymerase chain reaction (PCR) within 3 h of collection. Eighty handwashings from nurses dialyzing HCV-positive patients (groupe A) and 100 handwashing from nurses dialyzing HCV-negative patients (group B) were tested for HCV-RNA. As a control, 60 handwashings were collected from the dialysis personnel before entering the dialysis unit (group C) and tested for HCV-RNA. Results: HCV-RNA was positive in 19 (23.75%) of samples of group A, in 8 (8%) of samples of group B (p < 0.003) and in 2 (3.3%) of samples of group C (p < 0.35). These two positive samples of group C were from nurses who had dialyzed HCV-negative patients. Conclusion: These results indicate the presence of HCV-RNA on the hands of some dialysis personnel in our HD unit, in spite fo adherence to the standard precautions. The hands of dialysis personnel are therefore a potential mode for facilitating transmission of HCV between HD patients.</description><identifier>ISSN: 0250-8095</identifier><identifier>EISSN: 1421-9670</identifier><identifier>DOI: 10.1159/000013565</identifier><identifier>PMID: 10773609</identifier><identifier>CODEN: AJNED9</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Clinical Study ; Cross Infection - prevention & control ; Cross Infection - transmission ; Cross Infection - virology ; DNA Primers - chemistry ; Emergency and intensive care: renal failure. Dialysis management ; Hand - virology ; Hand Disinfection ; Hemodialysis Units, Hospital ; Hepacivirus - genetics ; Hepacivirus - isolation & purification ; Hepatitis C ; Hepatitis C - transmission ; Hepatitis C - virology ; Hepatitis C Antibodies - analysis ; Hepatitis C virus ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; Intensive care medicine ; Medical sciences ; Nurse Practitioners ; Renal Dialysis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - analysis</subject><ispartof>American journal of nephrology, 2000-03, Vol.20 (2), p.103-106</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG Mar/Apr 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-6aea45986997bb005ad85e8024e3c91a13e0076ce60fb48eaab8d50662d346e33</citedby><cites>FETCH-LOGICAL-c415t-6aea45986997bb005ad85e8024e3c91a13e0076ce60fb48eaab8d50662d346e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1346061$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10773609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alfurayh, O.</creatorcontrib><creatorcontrib>Sabeel, A.</creatorcontrib><creatorcontrib>Al Ahdal, M.N.</creatorcontrib><creatorcontrib>Almeshari, K.</creatorcontrib><creatorcontrib>Kessie, G.</creatorcontrib><creatorcontrib>Hamid, M.</creatorcontrib><creatorcontrib>Dela Cruz, D.M.</creatorcontrib><title>Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients</title><title>American journal of nephrology</title><addtitle>Am J Nephrol</addtitle><description>Background: Hepatitis C virus (HCV) is a major cause of hepatitis in hemodialysis (HD) patients. Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological study in our HD unit to investigate if the hands of dialysis personnel could represent a mode of transmission of HCV among HD patients. Methods: One liter of sterile water was used for each handwashing of dialysis personnel. The washing was collected in a sterile container and tested for HCV-RNA by polymerase chain reaction (PCR) within 3 h of collection. Eighty handwashings from nurses dialyzing HCV-positive patients (groupe A) and 100 handwashing from nurses dialyzing HCV-negative patients (group B) were tested for HCV-RNA. As a control, 60 handwashings were collected from the dialysis personnel before entering the dialysis unit (group C) and tested for HCV-RNA. Results: HCV-RNA was positive in 19 (23.75%) of samples of group A, in 8 (8%) of samples of group B (p < 0.003) and in 2 (3.3%) of samples of group C (p < 0.35). These two positive samples of group C were from nurses who had dialyzed HCV-negative patients. Conclusion: These results indicate the presence of HCV-RNA on the hands of some dialysis personnel in our HD unit, in spite fo adherence to the standard precautions. The hands of dialysis personnel are therefore a potential mode for facilitating transmission of HCV between HD patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Clinical Study</subject><subject>Cross Infection - prevention & control</subject><subject>Cross Infection - transmission</subject><subject>Cross Infection - virology</subject><subject>DNA Primers - chemistry</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Hand - virology</subject><subject>Hand Disinfection</subject><subject>Hemodialysis Units, Hospital</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C</subject><subject>Hepatitis C - transmission</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C Antibodies - analysis</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Patient-to-Professional</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Nurse Practitioners</subject><subject>Renal Dialysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - analysis</subject><issn>0250-8095</issn><issn>1421-9670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0d2L1DAQAPAgireePvgsSDhE8KE6SZo0eTwW71ZZ9MCP1zJt0zO3bbImrXL_vdEuuohgXpLM_JhhGEIeM3jJmDSvIB8mpJJ3yIqVnBVGVXCXrIBLKDQYeUIepHSTEddQ3ScnDKpKKDArstug7-g6-AlH53FywdPvbvpCN3aff5NLdE0_uzgn6jz9MGHf020IO-evKfaTjcewuAopv77ZHBxD53C4TTl-lfPWT-khudfjkOyjw31KPl28_rjeFNv3l2_W59uiLZmcCoUWS2m0MqZqGgCJnZZWAy-taA1DJixApVqroG9KbREb3UlQineiVFaIU_J8qbuP4ets01SPLrV2GNDbMKe6YqB1Kar_Qg6GSc0gw7O_4E2Yo89D1FwoU0rOy4xeLKiNIaVo-3of3YjxtmZQ_9xT_XtP2T49FJyb0XZHcllMBs8OAFOLQx_Rty79cXlSUCyzJwvbYby28Si_dDn7Z_b87btfoN53vfgBizWtFw</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>Alfurayh, O.</creator><creator>Sabeel, A.</creator><creator>Al Ahdal, M.N.</creator><creator>Almeshari, K.</creator><creator>Kessie, G.</creator><creator>Hamid, M.</creator><creator>Dela Cruz, D.M.</creator><general>Karger</general><general>S. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Clinical Study</topic><topic>Cross Infection - prevention & control</topic><topic>Cross Infection - transmission</topic><topic>Cross Infection - virology</topic><topic>DNA Primers - chemistry</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Hand - virology</topic><topic>Hand Disinfection</topic><topic>Hemodialysis Units, Hospital</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C</topic><topic>Hepatitis C - transmission</topic><topic>Hepatitis C - virology</topic><topic>Hepatitis C Antibodies - analysis</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Patient-to-Professional</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Nurse Practitioners</topic><topic>Renal Dialysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alfurayh, O.</creatorcontrib><creatorcontrib>Sabeel, A.</creatorcontrib><creatorcontrib>Al Ahdal, M.N.</creatorcontrib><creatorcontrib>Almeshari, K.</creatorcontrib><creatorcontrib>Kessie, G.</creatorcontrib><creatorcontrib>Hamid, M.</creatorcontrib><creatorcontrib>Dela Cruz, D.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alfurayh, O.</au><au>Sabeel, A.</au><au>Al Ahdal, M.N.</au><au>Almeshari, K.</au><au>Kessie, G.</au><au>Hamid, M.</au><au>Dela Cruz, D.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients</atitle><jtitle>American journal of nephrology</jtitle><addtitle>Am J Nephrol</addtitle><date>2000-03-01</date><risdate>2000</risdate><volume>20</volume><issue>2</issue><spage>103</spage><epage>106</epage><pages>103-106</pages><issn>0250-8095</issn><eissn>1421-9670</eissn><coden>AJNED9</coden><abstract>Background: Hepatitis C virus (HCV) is a major cause of hepatitis in hemodialysis (HD) patients. Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological study in our HD unit to investigate if the hands of dialysis personnel could represent a mode of transmission of HCV among HD patients. Methods: One liter of sterile water was used for each handwashing of dialysis personnel. The washing was collected in a sterile container and tested for HCV-RNA by polymerase chain reaction (PCR) within 3 h of collection. Eighty handwashings from nurses dialyzing HCV-positive patients (groupe A) and 100 handwashing from nurses dialyzing HCV-negative patients (group B) were tested for HCV-RNA. As a control, 60 handwashings were collected from the dialysis personnel before entering the dialysis unit (group C) and tested for HCV-RNA. Results: HCV-RNA was positive in 19 (23.75%) of samples of group A, in 8 (8%) of samples of group B (p < 0.003) and in 2 (3.3%) of samples of group C (p < 0.35). These two positive samples of group C were from nurses who had dialyzed HCV-negative patients. Conclusion: These results indicate the presence of HCV-RNA on the hands of some dialysis personnel in our HD unit, in spite fo adherence to the standard precautions. The hands of dialysis personnel are therefore a potential mode for facilitating transmission of HCV between HD patients.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10773609</pmid><doi>10.1159/000013565</doi><tpages>4</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Clinical Study Cross Infection - prevention & control Cross Infection - transmission Cross Infection - virology DNA Primers - chemistry Emergency and intensive care: renal failure. Dialysis management Hand - virology Hand Disinfection Hemodialysis Units, Hospital Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C Hepatitis C - transmission Hepatitis C - virology Hepatitis C Antibodies - analysis Hepatitis C virus Humans Infectious Disease Transmission, Patient-to-Professional Intensive care medicine Medical sciences Nurse Practitioners Renal Dialysis Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - analysis |
| title | Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients |
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