Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2020, Vol.67(2), pp.153-160
Hauptverfasser:	Irie, Junichiro, Inagaki, Emi, Fujita, Masataka, Nakaya, Hideaki, Mitsuishi, Masanori, Yamaguchi, Shintaro, Yamashita, Kazuya, Shigaki, Shuhei, Ono, Takashi, Yukioka, Hideo, Okano, Hideyuki, Nabeshima, Yo-ichi, Imai, Shin-ichiro, Yasui, Masato, Tsubota, Kazuo, Itoh, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Administration, Oral Adult Aging Animal models Bilirubin Bilirubin - blood Blood Glucose - drug effects Blood Glucose - metabolism Blood pressure Blood Pressure - drug effects Body temperature Body Temperature - drug effects Chlorides - blood Chromatography, Liquid Creatinine Creatinine - blood Diagnostic Techniques, Ophthalmological Dose-Response Relationship, Drug Electrocardiography Healthy Volunteers Heart rate Heart Rate - drug effects Humans Intraocular Pressure - drug effects Japan Male Metabolites Middle Aged N-methyl-2-pyridone-5-carboxamide N-methyl-4-pyridone-5-carboxamide NAD Niacinamide - analogs & derivatives Niacinamide - metabolism Nicotinamide Nicotinamide mononucleotide Nicotinamide Mononucleotide - analogs & derivatives Nicotinamide Mononucleotide - metabolism Nicotinamide Mononucleotide - pharmacology Oral administration Oxygen - metabolism Pharmacokinetics Pyridones - metabolism Quality control Sleep Sleep - drug effects Tandem Mass Spectrometry Visual Acuity
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