Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma
Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-2...
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| Veröffentlicht in: | Chemistry of natural compounds 2020, Vol.56 (1), p.30-33 |
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| creator | Chen, Chao Cao, Tingting Li, Yong Hu, Yuegao Yang, Hongjun Yin, Shufan |
| description | Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biological activity results showed that
4a
,
4c
, and
4d
exhibited better antiproliferative activity than aloe-emodin for MDA-MB-231 cells at a concentration of 3 μM, and only
4a
and
4d
exhibited better antiproliferative activity for A549 cells at the same concentration level. |
| doi_str_mv | 10.1007/s10600-020-02937-z |
| format | Article |
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4a
,
4c
, and
4d
exhibited better antiproliferative activity than aloe-emodin for MDA-MB-231 cells at a concentration of 3 μM, and only
4a
and
4d
exhibited better antiproliferative activity for A549 cells at the same concentration level.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-020-02937-z</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenocarcinoma ; Aloe ; Biological activity ; Biological effects ; Derivatives ; Inhibitors ; Lung cancer, Non-small cell ; Lungs ; Medicine ; Medicine, Botanic ; Medicine, Herbal ; Organic Chemistry ; Penicillin G ; Pharmacy ; Plant Sciences ; Synthesis</subject><ispartof>Chemistry of natural compounds, 2020, Vol.56 (1), p.30-33</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>2020© Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-ec69325386ae7dd1f53cb25feb1ea1dbdd022ab9696b1d4c1087fa25a60a665d3</citedby><cites>FETCH-LOGICAL-c420t-ec69325386ae7dd1f53cb25feb1ea1dbdd022ab9696b1d4c1087fa25a60a665d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-020-02937-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-020-02937-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Cao, Tingting</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Hu, Yuegao</creatorcontrib><creatorcontrib>Yang, Hongjun</creatorcontrib><creatorcontrib>Yin, Shufan</creatorcontrib><title>Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biological activity results showed that
4a
,
4c
, and
4d
exhibited better antiproliferative activity than aloe-emodin for MDA-MB-231 cells at a concentration of 3 μM, and only
4a
and
4d
exhibited better antiproliferative activity for A549 cells at the same concentration level.</description><subject>Adenocarcinoma</subject><subject>Aloe</subject><subject>Biological activity</subject><subject>Biological effects</subject><subject>Derivatives</subject><subject>Inhibitors</subject><subject>Lung cancer, Non-small cell</subject><subject>Lungs</subject><subject>Medicine</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Organic Chemistry</subject><subject>Penicillin G</subject><subject>Pharmacy</subject><subject>Plant Sciences</subject><subject>Synthesis</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kt-KEzEUhwdRsK6-gFcBrwRnzZ9OZuay1tUtFBVXr8OZ5KSbZSZZk5my28fxSU1toRREQhKS830JCb-ieM3oJaO0fp8YlZSWlO97K-py96SYsaoWZSOa5mkxo5S2pWCCPi9epHSXl42Uzaz4ffPox1tMboeGfMTotjC6LSYSLFn0AcurIRjnCSTyLYbeWYwZCJ6s_K3r3BhiIjZEcj0N4MmHiJBGsjDog4aonQ8DvDsWvwSfBuh7ssQ8rCe_IcsTA94cuSXGrXs41V4Wzyz0CV8d54vi56erH8vrcv3182q5WJd6zulYopat4JVoJGBtDLOV0B2vLHYMgZnOGMo5dK1sZcfMXDPa1BZ4BZKClJURF8Wbw7n3MfyaMI3qLkzR5ysVF7Juq7lo-InaQI_KeRvGCHpwSauFzD_OhGB76vIfVG4GB6eDR-vy_pnw9kzIzIgP4wamlNTq5vs5yw-sjiGliFbdRzdAfFSMqn0c1CEOKsdB_Y2D2mVJHKSUYb_BeHrdf6w_QJm4vQ</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Chen, Chao</creator><creator>Cao, Tingting</creator><creator>Li, Yong</creator><creator>Hu, Yuegao</creator><creator>Yang, Hongjun</creator><creator>Yin, Shufan</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>2020</creationdate><title>Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma</title><author>Chen, Chao ; Cao, Tingting ; Li, Yong ; Hu, Yuegao ; Yang, Hongjun ; Yin, Shufan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-ec69325386ae7dd1f53cb25feb1ea1dbdd022ab9696b1d4c1087fa25a60a665d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenocarcinoma</topic><topic>Aloe</topic><topic>Biological activity</topic><topic>Biological effects</topic><topic>Derivatives</topic><topic>Inhibitors</topic><topic>Lung cancer, Non-small cell</topic><topic>Lungs</topic><topic>Medicine</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Organic Chemistry</topic><topic>Penicillin G</topic><topic>Pharmacy</topic><topic>Plant Sciences</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chao</creatorcontrib><creatorcontrib>Cao, Tingting</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Hu, Yuegao</creatorcontrib><creatorcontrib>Yang, Hongjun</creatorcontrib><creatorcontrib>Yin, Shufan</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chao</au><au>Cao, Tingting</au><au>Li, Yong</au><au>Hu, Yuegao</au><au>Yang, Hongjun</au><au>Yin, Shufan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2020</date><risdate>2020</risdate><volume>56</volume><issue>1</issue><spage>30</spage><epage>33</epage><pages>30-33</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biological activity results showed that
4a
,
4c
, and
4d
exhibited better antiproliferative activity than aloe-emodin for MDA-MB-231 cells at a concentration of 3 μM, and only
4a
and
4d
exhibited better antiproliferative activity for A549 cells at the same concentration level.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-020-02937-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenocarcinoma Aloe Biological activity Biological effects Derivatives Inhibitors Lung cancer, Non-small cell Lungs Medicine Medicine, Botanic Medicine, Herbal Organic Chemistry Penicillin G Pharmacy Plant Sciences Synthesis |
| title | Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma |
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