Peripheral venous route for administration of ammonul infusion for treatment of acute hyperammonemia

Objectives: To determine the local effects of peripheral Ammonul infusion on the skin and the subcutaneous tissues. Methods: This retrospective study was conducted at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. All children

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Veröffentlicht in:Saudi medical journal 2020-01, Vol.41 (1), p.98-101
Hauptverfasser: Alhashem, Amal M, Salih, Rihab M, Al-Aqeel, Aida I, Sarar, Mohamed
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container_title Saudi medical journal
container_volume 41
creator Alhashem, Amal M
Salih, Rihab M
Al-Aqeel, Aida I
Sarar, Mohamed
description Objectives: To determine the local effects of peripheral Ammonul infusion on the skin and the subcutaneous tissues. Methods: This retrospective study was conducted at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. All children
doi_str_mv 10.15537/smj.2020.1.24760
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Methods: This retrospective study was conducted at Prince Sultan Military Medical City, Riyadh, Saudi Arabia. All children &lt;16 years of age admitted between December 2015 and October 2018 with hyperammonemia and received Ammonul infusion for treatment were recruited. Results: Twenty-one patients received the Ammonul infusion. They were admitted 58 times with acute hyperammonemia during the study period, with an average of 2.8 admissions per patient. The mean age of the included patients was 49.5 months. The most frequent underlying diagnoses were propionic acidemia (n=9), urea cycle disorders (n=5), and intrinsic liver disease (n=3). All participants received Ammonul through peripheral lines except 3 who received it through central lines. No extravasation, burns, or other local side effects were observed in this cohort. Conclusion: This data indicate that the use of Ammonul through a peripheral venous route appears to be safe and not associated with infusion-related local adverse effects.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2020.1.24760</identifier><language>eng</language><publisher>Riyadh: Prince Sultan Military Medical City (PSMMC)</publisher><subject>Burns ; Iatrogenesis ; Intravenous therapy ; Patient safety ; Skin</subject><ispartof>Saudi medical journal, 2020-01, Vol.41 (1), p.98-101</ispartof><rights>Saudi Medical Journal 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). 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subjects Burns
Iatrogenesis
Intravenous therapy
Patient safety
Skin
title Peripheral venous route for administration of ammonul infusion for treatment of acute hyperammonemia
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