0117 Differences In Ventricular Repolarization Between NREM And REM Sleep
Introduction Ventricular repolarization is a critical time during the cardiac cycle given its role in the pathophysiology of malignant arrhythmias. The QT Variability Index (QTVi), a measure of repolarization lability, has been associated with increased risk of ventricular arrhythmias including sudd...
Gespeichert in:
| Veröffentlicht in: | Sleep (New York, N.Y.) N.Y.), 2019-04, Vol.42 (Supplement_1), p.A48-A48 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | A48 |
|---|---|
| container_issue | Supplement_1 |
| container_start_page | A48 |
| container_title | Sleep (New York, N.Y.) |
| container_volume | 42 |
| creator | Samtani, Nikhil Haigney, Mark Punjabi, Naresh M |
| description | Introduction Ventricular repolarization is a critical time during the cardiac cycle given its role in the pathophysiology of malignant arrhythmias. The QT Variability Index (QTVi), a measure of repolarization lability, has been associated with increased risk of ventricular arrhythmias including sudden cardiac death. Given that autonomic tone can vary during sleep, the aim of this study was to characterize NREM-REM differences in QTVi. To describe the ultradian variation, QTVi during NREM-REM sleep was examined in healthy adults. Methods A cohort of healthy men and women was identified from the Sleep Heart Health Study. Prevalent medical comorbidity such as hypertension, cardiovascular disease, and stroke were exclusionary. The ECG signal was extracted from the full montage home sleep recording and analyzed in Matlab to characterize QTVi in 30-second epochs. Given the skewed distribution of QTV, a log transformation was used. Mixed model regression was used to compare QTVi during wakefulness, NREM, and REM sleep with adjustments for age, sex and BMI. Results The sample included 87 healthy participants. The mean BMI and age was 26.6 kg/m2 and 56.2 years, respectively. The fully adjusted QTVi values for men and women during wakefulness were -1.62 and -1.39, respectively (p |
| doi_str_mv | 10.1093/sleep/zsz067.116 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2365130944</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2365130944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1116-dfa7df659c1de9c85589a3b70c30bddba33b68f9dfb5983fe0fe57e301ad6e823</originalsourceid><addsrcrecordid>eNotkM1LAzEQxYMoWKt3jwHP2840TXZzrLVqoSrUj2vIbiawpe6uyRaxf72p9fQY5vHe48fYNcIIQYtx3BJ1433cg8pHiOqEDVBKyHT6nrIBoMKsQJDn7CLGDaR7qsWALQEx53e19xSoqSjyZcM_qOlDXe22NvA1dW3Sem_7um34LfXfRA1_Xi-e-Kxx_KCvh-5LdubtNtLVvw7Z-_3ibf6YrV4elvPZKqswzcqct7nzSuoKHemqkLLQVpQ5VAJK50orRKkKr50vpS6EJ_AkcxKA1ikqJmLIbo65XWi_dhR7s2l3oUmVZiKURAF6Ok0uOLqq0MYYyJsu1J82_BgEcwBm_oCZIzCTlolfIiZfmw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2365130944</pqid></control><display><type>article</type><title>0117 Differences In Ventricular Repolarization Between NREM And REM Sleep</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Samtani, Nikhil ; Haigney, Mark ; Punjabi, Naresh M</creator><creatorcontrib>Samtani, Nikhil ; Haigney, Mark ; Punjabi, Naresh M</creatorcontrib><description><![CDATA[Introduction Ventricular repolarization is a critical time during the cardiac cycle given its role in the pathophysiology of malignant arrhythmias. The QT Variability Index (QTVi), a measure of repolarization lability, has been associated with increased risk of ventricular arrhythmias including sudden cardiac death. Given that autonomic tone can vary during sleep, the aim of this study was to characterize NREM-REM differences in QTVi. To describe the ultradian variation, QTVi during NREM-REM sleep was examined in healthy adults. Methods A cohort of healthy men and women was identified from the Sleep Heart Health Study. Prevalent medical comorbidity such as hypertension, cardiovascular disease, and stroke were exclusionary. The ECG signal was extracted from the full montage home sleep recording and analyzed in Matlab to characterize QTVi in 30-second epochs. Given the skewed distribution of QTV, a log transformation was used. Mixed model regression was used to compare QTVi during wakefulness, NREM, and REM sleep with adjustments for age, sex and BMI. Results The sample included 87 healthy participants. The mean BMI and age was 26.6 kg/m2 and 56.2 years, respectively. The fully adjusted QTVi values for men and women during wakefulness were -1.62 and -1.39, respectively (p<0.04). In women, compared to wakefulness, QTVi was lower during NREM sleep (-1.39 vs -1.41; p<0.06) and higher during REM sleep (-1.39 vs. -1.34; p<0.001). In men, QTVi was also lower during NREM sleep (-1.62 vs -1.64; p<0.06) and higher during REM sleep (-1.62 vs. -1.58; p<0.001). Finally, there was a temporal variation in QTVi with progressively lower values in the latter segments of the night (p<0.001 for trend across the night). Conclusion In healthy people, ventricular repolarization has an ultradian pattern and differs between NREM and REM sleep. Differences in ventricular repolarization likely reflect inherent differences in the autonomic activity during NREM and REM sleep. Research into the impact of sleep disorders, such as obstructive sleep apnea, on ventricular repolarization and risk for sudden cardiac death should take into consideration these expected differences in markers of ventricular repolarization. Support (If Any) NIH grant HL117167]]></description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsz067.116</identifier><language>eng</language><publisher>Westchester: Oxford University Press</publisher><subject>Cardiac arrhythmia ; Electrocardiography ; NREM sleep ; REM sleep ; Sleep ; Women</subject><ispartof>Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A48-A48</ispartof><rights>Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Samtani, Nikhil</creatorcontrib><creatorcontrib>Haigney, Mark</creatorcontrib><creatorcontrib>Punjabi, Naresh M</creatorcontrib><title>0117 Differences In Ventricular Repolarization Between NREM And REM Sleep</title><title>Sleep (New York, N.Y.)</title><description><![CDATA[Introduction Ventricular repolarization is a critical time during the cardiac cycle given its role in the pathophysiology of malignant arrhythmias. The QT Variability Index (QTVi), a measure of repolarization lability, has been associated with increased risk of ventricular arrhythmias including sudden cardiac death. Given that autonomic tone can vary during sleep, the aim of this study was to characterize NREM-REM differences in QTVi. To describe the ultradian variation, QTVi during NREM-REM sleep was examined in healthy adults. Methods A cohort of healthy men and women was identified from the Sleep Heart Health Study. Prevalent medical comorbidity such as hypertension, cardiovascular disease, and stroke were exclusionary. The ECG signal was extracted from the full montage home sleep recording and analyzed in Matlab to characterize QTVi in 30-second epochs. Given the skewed distribution of QTV, a log transformation was used. Mixed model regression was used to compare QTVi during wakefulness, NREM, and REM sleep with adjustments for age, sex and BMI. Results The sample included 87 healthy participants. The mean BMI and age was 26.6 kg/m2 and 56.2 years, respectively. The fully adjusted QTVi values for men and women during wakefulness were -1.62 and -1.39, respectively (p<0.04). In women, compared to wakefulness, QTVi was lower during NREM sleep (-1.39 vs -1.41; p<0.06) and higher during REM sleep (-1.39 vs. -1.34; p<0.001). In men, QTVi was also lower during NREM sleep (-1.62 vs -1.64; p<0.06) and higher during REM sleep (-1.62 vs. -1.58; p<0.001). Finally, there was a temporal variation in QTVi with progressively lower values in the latter segments of the night (p<0.001 for trend across the night). Conclusion In healthy people, ventricular repolarization has an ultradian pattern and differs between NREM and REM sleep. Differences in ventricular repolarization likely reflect inherent differences in the autonomic activity during NREM and REM sleep. Research into the impact of sleep disorders, such as obstructive sleep apnea, on ventricular repolarization and risk for sudden cardiac death should take into consideration these expected differences in markers of ventricular repolarization. Support (If Any) NIH grant HL117167]]></description><subject>Cardiac arrhythmia</subject><subject>Electrocardiography</subject><subject>NREM sleep</subject><subject>REM sleep</subject><subject>Sleep</subject><subject>Women</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNotkM1LAzEQxYMoWKt3jwHP2840TXZzrLVqoSrUj2vIbiawpe6uyRaxf72p9fQY5vHe48fYNcIIQYtx3BJ1433cg8pHiOqEDVBKyHT6nrIBoMKsQJDn7CLGDaR7qsWALQEx53e19xSoqSjyZcM_qOlDXe22NvA1dW3Sem_7um34LfXfRA1_Xi-e-Kxx_KCvh-5LdubtNtLVvw7Z-_3ibf6YrV4elvPZKqswzcqct7nzSuoKHemqkLLQVpQ5VAJK50orRKkKr50vpS6EJ_AkcxKA1ikqJmLIbo65XWi_dhR7s2l3oUmVZiKURAF6Ok0uOLqq0MYYyJsu1J82_BgEcwBm_oCZIzCTlolfIiZfmw</recordid><startdate>20190413</startdate><enddate>20190413</enddate><creator>Samtani, Nikhil</creator><creator>Haigney, Mark</creator><creator>Punjabi, Naresh M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20190413</creationdate><title>0117 Differences In Ventricular Repolarization Between NREM And REM Sleep</title><author>Samtani, Nikhil ; Haigney, Mark ; Punjabi, Naresh M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1116-dfa7df659c1de9c85589a3b70c30bddba33b68f9dfb5983fe0fe57e301ad6e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cardiac arrhythmia</topic><topic>Electrocardiography</topic><topic>NREM sleep</topic><topic>REM sleep</topic><topic>Sleep</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samtani, Nikhil</creatorcontrib><creatorcontrib>Haigney, Mark</creatorcontrib><creatorcontrib>Punjabi, Naresh M</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samtani, Nikhil</au><au>Haigney, Mark</au><au>Punjabi, Naresh M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>0117 Differences In Ventricular Repolarization Between NREM And REM Sleep</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2019-04-13</date><risdate>2019</risdate><volume>42</volume><issue>Supplement_1</issue><spage>A48</spage><epage>A48</epage><pages>A48-A48</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract><![CDATA[Introduction Ventricular repolarization is a critical time during the cardiac cycle given its role in the pathophysiology of malignant arrhythmias. The QT Variability Index (QTVi), a measure of repolarization lability, has been associated with increased risk of ventricular arrhythmias including sudden cardiac death. Given that autonomic tone can vary during sleep, the aim of this study was to characterize NREM-REM differences in QTVi. To describe the ultradian variation, QTVi during NREM-REM sleep was examined in healthy adults. Methods A cohort of healthy men and women was identified from the Sleep Heart Health Study. Prevalent medical comorbidity such as hypertension, cardiovascular disease, and stroke were exclusionary. The ECG signal was extracted from the full montage home sleep recording and analyzed in Matlab to characterize QTVi in 30-second epochs. Given the skewed distribution of QTV, a log transformation was used. Mixed model regression was used to compare QTVi during wakefulness, NREM, and REM sleep with adjustments for age, sex and BMI. Results The sample included 87 healthy participants. The mean BMI and age was 26.6 kg/m2 and 56.2 years, respectively. The fully adjusted QTVi values for men and women during wakefulness were -1.62 and -1.39, respectively (p<0.04). In women, compared to wakefulness, QTVi was lower during NREM sleep (-1.39 vs -1.41; p<0.06) and higher during REM sleep (-1.39 vs. -1.34; p<0.001). In men, QTVi was also lower during NREM sleep (-1.62 vs -1.64; p<0.06) and higher during REM sleep (-1.62 vs. -1.58; p<0.001). Finally, there was a temporal variation in QTVi with progressively lower values in the latter segments of the night (p<0.001 for trend across the night). Conclusion In healthy people, ventricular repolarization has an ultradian pattern and differs between NREM and REM sleep. Differences in ventricular repolarization likely reflect inherent differences in the autonomic activity during NREM and REM sleep. Research into the impact of sleep disorders, such as obstructive sleep apnea, on ventricular repolarization and risk for sudden cardiac death should take into consideration these expected differences in markers of ventricular repolarization. Support (If Any) NIH grant HL117167]]></abstract><cop>Westchester</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsz067.116</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A48-A48 |
| issn | 0161-8105 1550-9109 |
| language | eng |
| recordid | cdi_proquest_journals_2365130944 |
| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cardiac arrhythmia Electrocardiography NREM sleep REM sleep Sleep Women |
| title | 0117 Differences In Ventricular Repolarization Between NREM And REM Sleep |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T15%3A36%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=0117%20Differences%20In%20Ventricular%20Repolarization%20Between%20NREM%20And%20REM%20Sleep&rft.jtitle=Sleep%20(New%20York,%20N.Y.)&rft.au=Samtani,%20Nikhil&rft.date=2019-04-13&rft.volume=42&rft.issue=Supplement_1&rft.spage=A48&rft.epage=A48&rft.pages=A48-A48&rft.issn=0161-8105&rft.eissn=1550-9109&rft_id=info:doi/10.1093/sleep/zsz067.116&rft_dat=%3Cproquest_cross%3E2365130944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2365130944&rft_id=info:pmid/&rfr_iscdi=true |