Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish
Per‐ and poly‐fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8HF15O2), perfluorooctane sulfonate (PFOS; C8HF17SO3), and hex...
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| Veröffentlicht in: | Environmental toxicology and chemistry 2020-03, Vol.39 (3), p.595-603 |
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| creator | Hassell, Kathryn L. Coggan, Timothy L. Cresswell, Tom Kolobaric, Adam Berry, Kathryn Crosbie, Nicholas D. Blackbeard, Judy Pettigrove, Vincent J. Clarke, Bradley O. |
| description | Per‐ and poly‐fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8HF15O2), perfluorooctane sulfonate (PFOS; C8HF17SO3), and hexafluoropropylene oxide dimer acid (HPFO‐DA; C6HF11O3; trade name GenX). Benthic fish (blue spot gobies, Pseudogobius sp.) were fed contaminated food (nominal dose 500 ng g–1) daily for a 21‐d uptake period, followed by a 42‐d depuration period. The compounds PFOA, linear‐PFOS (linear PFOS), and total PFOS (sum of linear and branched PFOS) were detected in freeze‐dried fish, whereas GenX was not, indicating either a lack of uptake or rapid elimination ( |
| doi_str_mv | 10.1002/etc.4640 |
| format | Article |
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Individually housed fish were exposed to a mixture of per‐ and poly‐fluoroalkyl substances (PFAS) via contaminated food for a 21‐d uptake period, followed by a 42‐d depuration period. At regular intervals fish were removed, and freeze‐dried whole‐body tissue was analyzed. PFOA = perfluorooctanoic acid; LC–MS/MS = liquid chromatography–tandem mass spectrometry.</description><identifier>ISSN: 0730-7268</identifier><identifier>EISSN: 1552-8618</identifier><identifier>DOI: 10.1002/etc.4640</identifier><identifier>PMID: 31751491</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Acids ; Aquatic environment ; Bioaccumulation ; Depuration ; Dimers ; Fish ; Food contamination ; GenX ; Hexafluoropropylene oxide dimer acid ; Isomeric differences ; Isomers ; Perfluoro compounds ; Perfluoroalkyl substance ; Perfluorooctanoic acid ; Per‐ and poly‐fluoroalkyl substances ; Sulfonates</subject><ispartof>Environmental toxicology and chemistry, 2020-03, Vol.39 (3), p.595-603</ispartof><rights>2019 SETAC</rights><rights>2019 SETAC.</rights><rights>2020 SETAC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4200-3b77e122f1b5bdbc81969e511554756152d6e31c0009be1294879367720d56783</citedby><cites>FETCH-LOGICAL-c4200-3b77e122f1b5bdbc81969e511554756152d6e31c0009be1294879367720d56783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fetc.4640$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fetc.4640$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31751491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassell, Kathryn L.</creatorcontrib><creatorcontrib>Coggan, Timothy L.</creatorcontrib><creatorcontrib>Cresswell, Tom</creatorcontrib><creatorcontrib>Kolobaric, Adam</creatorcontrib><creatorcontrib>Berry, Kathryn</creatorcontrib><creatorcontrib>Crosbie, Nicholas D.</creatorcontrib><creatorcontrib>Blackbeard, Judy</creatorcontrib><creatorcontrib>Pettigrove, Vincent J.</creatorcontrib><creatorcontrib>Clarke, Bradley O.</creatorcontrib><title>Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish</title><title>Environmental toxicology and chemistry</title><addtitle>Environ Toxicol Chem</addtitle><description>Per‐ and poly‐fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8HF15O2), perfluorooctane sulfonate (PFOS; C8HF17SO3), and hexafluoropropylene oxide dimer acid (HPFO‐DA; C6HF11O3; trade name GenX). Benthic fish (blue spot gobies, Pseudogobius sp.) were fed contaminated food (nominal dose 500 ng g–1) daily for a 21‐d uptake period, followed by a 42‐d depuration period. The compounds PFOA, linear‐PFOS (linear PFOS), and total PFOS (sum of linear and branched PFOS) were detected in freeze‐dried fish, whereas GenX was not, indicating either a lack of uptake or rapid elimination (<24 h). Depuration rates (d–1) were 0.150 (PFOA), 0.045 (linear‐PFOS), and 0.042 (linear+branched‐PFOS) with corresponding biological half‐lives of 5.9, 15, and 16 d, respectively. The PFOS isomers were eliminated differently, resulting in enrichment of linear‐PFOS (70–90%) throughout the depuration period. The present study is the first reported study of GenX dietary bioaccumulation potential in fish, and the first dietary study to investigate uptake and depuration of multiple PFASs simultaneously, allowing us to determine that whereas PFOA and PFOS accumulated as expected, GenX, administered in the same way, did not appear to bioaccumulate. Environ Toxicol Chem 2020;39:595–603. © 2019 SETAC
Individually housed fish were exposed to a mixture of per‐ and poly‐fluoroalkyl substances (PFAS) via contaminated food for a 21‐d uptake period, followed by a 42‐d depuration period. At regular intervals fish were removed, and freeze‐dried whole‐body tissue was analyzed. PFOA = perfluorooctanoic acid; LC–MS/MS = liquid chromatography–tandem mass spectrometry.</description><subject>Acids</subject><subject>Aquatic environment</subject><subject>Bioaccumulation</subject><subject>Depuration</subject><subject>Dimers</subject><subject>Fish</subject><subject>Food contamination</subject><subject>GenX</subject><subject>Hexafluoropropylene oxide dimer acid</subject><subject>Isomeric differences</subject><subject>Isomers</subject><subject>Perfluoro compounds</subject><subject>Perfluoroalkyl substance</subject><subject>Perfluorooctanoic acid</subject><subject>Per‐ and poly‐fluoroalkyl substances</subject><subject>Sulfonates</subject><issn>0730-7268</issn><issn>1552-8618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1KxDAURoMoOv6ATyABNwpTTdI2aZajo6MoKKjgrqTpLUY7yZim6LyMz2qcUReCEMjinpxcvg-hXUqOKCHsGII-ynhGVtCA5jlLCk6LVTQgIiWJYLzYQJtd90wI5VLKdbSRUpHTTNIB-hgbCMrP8cMsqBfAytZ4DLPeq2CcxVfGQjC6w67Bt-CbtnfeOR2UBXzXt42zKsDwz8gZjUfa1MOF7QLe1XI4i2feQnx6825qwGMzBb8g8cEE7OMhNhYrfAI2PEXFuemettFao9oOdr7vLfRwfnZ_epFc30wuT0fXic4YIUlaCQGUsYZWeVVXuqCSS8hpDCMTOac5qzmkVBNCZBVBmRVCplwIRuqciyLdQvtLb9zxtYculM-u9zZ-WbI0BiuLQrJIHSwp7V3XeWjKmTfTmF5JSflVRBmLKL-KiOjet7CvplD_gj_JRyBZAm-mhfm_ojIyC-EnPxKRLQ</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Hassell, Kathryn L.</creator><creator>Coggan, Timothy L.</creator><creator>Cresswell, Tom</creator><creator>Kolobaric, Adam</creator><creator>Berry, Kathryn</creator><creator>Crosbie, Nicholas D.</creator><creator>Blackbeard, Judy</creator><creator>Pettigrove, Vincent J.</creator><creator>Clarke, Bradley O.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope></search><sort><creationdate>202003</creationdate><title>Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish</title><author>Hassell, Kathryn L. ; Coggan, Timothy L. ; Cresswell, Tom ; Kolobaric, Adam ; Berry, Kathryn ; Crosbie, Nicholas D. ; Blackbeard, Judy ; Pettigrove, Vincent J. ; Clarke, Bradley O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4200-3b77e122f1b5bdbc81969e511554756152d6e31c0009be1294879367720d56783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Aquatic environment</topic><topic>Bioaccumulation</topic><topic>Depuration</topic><topic>Dimers</topic><topic>Fish</topic><topic>Food contamination</topic><topic>GenX</topic><topic>Hexafluoropropylene oxide dimer acid</topic><topic>Isomeric differences</topic><topic>Isomers</topic><topic>Perfluoro compounds</topic><topic>Perfluoroalkyl substance</topic><topic>Perfluorooctanoic acid</topic><topic>Per‐ and poly‐fluoroalkyl substances</topic><topic>Sulfonates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassell, Kathryn L.</creatorcontrib><creatorcontrib>Coggan, Timothy L.</creatorcontrib><creatorcontrib>Cresswell, Tom</creatorcontrib><creatorcontrib>Kolobaric, Adam</creatorcontrib><creatorcontrib>Berry, Kathryn</creatorcontrib><creatorcontrib>Crosbie, Nicholas D.</creatorcontrib><creatorcontrib>Blackbeard, Judy</creatorcontrib><creatorcontrib>Pettigrove, Vincent J.</creatorcontrib><creatorcontrib>Clarke, Bradley O.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology and chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassell, Kathryn L.</au><au>Coggan, Timothy L.</au><au>Cresswell, Tom</au><au>Kolobaric, Adam</au><au>Berry, Kathryn</au><au>Crosbie, Nicholas D.</au><au>Blackbeard, Judy</au><au>Pettigrove, Vincent J.</au><au>Clarke, Bradley O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish</atitle><jtitle>Environmental toxicology and chemistry</jtitle><addtitle>Environ Toxicol Chem</addtitle><date>2020-03</date><risdate>2020</risdate><volume>39</volume><issue>3</issue><spage>595</spage><epage>603</epage><pages>595-603</pages><issn>0730-7268</issn><eissn>1552-8618</eissn><abstract>Per‐ and poly‐fluoroalkyl substances (PFAS) are ubiquitously distributed throughout aquatic environments and can bioaccumulate in organisms. We examined dietary uptake and depuration of a mixture of 3 PFAS: perfluorooctanoic acid (PFOA; C8HF15O2), perfluorooctane sulfonate (PFOS; C8HF17SO3), and hexafluoropropylene oxide dimer acid (HPFO‐DA; C6HF11O3; trade name GenX). Benthic fish (blue spot gobies, Pseudogobius sp.) were fed contaminated food (nominal dose 500 ng g–1) daily for a 21‐d uptake period, followed by a 42‐d depuration period. The compounds PFOA, linear‐PFOS (linear PFOS), and total PFOS (sum of linear and branched PFOS) were detected in freeze‐dried fish, whereas GenX was not, indicating either a lack of uptake or rapid elimination (<24 h). Depuration rates (d–1) were 0.150 (PFOA), 0.045 (linear‐PFOS), and 0.042 (linear+branched‐PFOS) with corresponding biological half‐lives of 5.9, 15, and 16 d, respectively. The PFOS isomers were eliminated differently, resulting in enrichment of linear‐PFOS (70–90%) throughout the depuration period. The present study is the first reported study of GenX dietary bioaccumulation potential in fish, and the first dietary study to investigate uptake and depuration of multiple PFASs simultaneously, allowing us to determine that whereas PFOA and PFOS accumulated as expected, GenX, administered in the same way, did not appear to bioaccumulate. Environ Toxicol Chem 2020;39:595–603. © 2019 SETAC
Individually housed fish were exposed to a mixture of per‐ and poly‐fluoroalkyl substances (PFAS) via contaminated food for a 21‐d uptake period, followed by a 42‐d depuration period. At regular intervals fish were removed, and freeze‐dried whole‐body tissue was analyzed. PFOA = perfluorooctanoic acid; LC–MS/MS = liquid chromatography–tandem mass spectrometry.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>31751491</pmid><doi>10.1002/etc.4640</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental toxicology and chemistry, 2020-03, Vol.39 (3), p.595-603 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Acids Aquatic environment Bioaccumulation Depuration Dimers Fish Food contamination GenX Hexafluoropropylene oxide dimer acid Isomeric differences Isomers Perfluoro compounds Perfluoroalkyl substance Perfluorooctanoic acid Per‐ and poly‐fluoroalkyl substances Sulfonates |
| title | Dietary Uptake and Depuration Kinetics of Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Hexafluoropropylene Oxide Dimer Acid (GenX) in a Benthic Fish |
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