Tobacco smoking and somatic mutations in human bronchial epithelium

Tobacco smoking causes lung cancer 1 – 3 , a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA 4 , 5 . The profound effects of tobacco on the genome of lung cancer cells are well-documented 6 – 10 , but equivalent data for normal bronchial cell...

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Veröffentlicht in:	Nature (London) 2020-02, Vol.578 (7794), p.266-272
Hauptverfasser:	Yoshida, Kenichi, Gowers, Kate H. C., Lee-Six, Henry, Chandrasekharan, Deepak P., Coorens, Tim, Maughan, Elizabeth F., Beal, Kathryn, Menzies, Andrew, Millar, Fraser R., Anderson, Elizabeth, Clarke, Sarah E., Pennycuick, Adam, Thakrar, Ricky M., Butler, Colin R., Kakiuchi, Nobuyuki, Hirano, Tomonori, Hynds, Robert E., Stratton, Michael R., Martincorena, Iñigo, Janes, Sam M., Campbell, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 631/208/737 631/67/69 Adolescent Adult Age Aged Aged, 80 and over Between-subjects design Bronchi Bronchi - cytology Bronchi - metabolism Bronchi - pathology Carcinogens Child Cigarette smoke Clone Cells - cytology Clone Cells - metabolism Damage DNA Mutational Analysis Epithelial cells Epithelium Equivalence Female Genetic aspects Genomes Health aspects Heterogeneity Humanities and Social Sciences Humans Lung cancer Lung diseases Lung Neoplasms - etiology Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged multidisciplinary Mutagenesis Mutation Mutation (Biology) Mutation - genetics Physiological aspects Replenishment Respiratory Mucosa - cytology Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Science Science (multidisciplinary) Smoke Smokers Smoking Somatic cells Standard deviation Telomere - genetics Telomere - metabolism Telomeres Tobacco Tobacco products Tobacco smoking Tobacco Smoking - adverse effects Tobacco Smoking - genetics Tobacco Smoking - pathology Young Adult
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