Influence of Radial Pressure Wave Therapy (RPWT) on collagenase-induced Achilles tendinopathy treated with Platelet Rich Plasma and Autologous Adipose Derived Stem Cells
Tendinopathy treatment poses a current challenge for sport medicine due to unique physiology and biomechanics of tendons. The goal of this work was to compare the efficacy of the addition of the radial pressure wave therapy (RPWT) treatment to injection of autologous Adipose Derived Stem Cells (ADSC...
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| Veröffentlicht in: | Polish journal of veterinary sciences 2019-12, Vol.22 (4), p.743-751 |
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| description | Tendinopathy treatment poses a current challenge for sport medicine due to unique physiology and biomechanics of tendons. The goal of this work was to compare the efficacy of the addition of the radial pressure wave therapy (RPWT) treatment to injection of autologous Adipose Derived Stem Cells (ADSCs) or Platelet Rich Plasma (PRP) in the therapeutic procedure for collagenase induced Achilles tendinopathy in sheep. 14 sheep (aged 5 and 6 years, Polish Mountain Sheep breed, weight 60-70 kg) were injected bacterial collagenase type 1A-S (Clostridium histolyticum, C-5894, Sigma Aldrich, Poznań, Poland) bilaterally to Achilles tendons. Subsequently, the animals were injected with PRP (7 sheep) or ADSCs (7 sheep) to previously induced tendinopathy foci. Left limbs of all the animals were additionally treated with RPWT focused above the tendinopathy origins. Treatment progress was controlled by ultrasound scans, and tendon samples were taken on the 126th day of the experiment. Tendon samples taken from the sheep treated with RPWT+ADSCs showed lower cellularity and the highest number of thick collage fibers. Samples taken from the sheep treated with RPWT+PRP showed an elevated rate of neovascularization. Addition of the RPWT to ADSCs injections in the treatment of induced Achilles tendinopathy in sheep resulted in good quality of the tissue regeneration. Dual therapy with RPWT+PRP injection can lead to neovascularization in the tendon tissue. |
| doi_str_mv | 10.24425/pjvs.2019.131405 |
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The goal of this work was to compare the efficacy of the addition of the radial pressure wave therapy (RPWT) treatment to injection of autologous Adipose Derived Stem Cells (ADSCs) or Platelet Rich Plasma (PRP) in the therapeutic procedure for collagenase induced Achilles tendinopathy in sheep. 14 sheep (aged 5 and 6 years, Polish Mountain Sheep breed, weight 60-70 kg) were injected bacterial collagenase type 1A-S (Clostridium histolyticum, C-5894, Sigma Aldrich, Poznań, Poland) bilaterally to Achilles tendons. Subsequently, the animals were injected with PRP (7 sheep) or ADSCs (7 sheep) to previously induced tendinopathy foci. Left limbs of all the animals were additionally treated with RPWT focused above the tendinopathy origins. Treatment progress was controlled by ultrasound scans, and tendon samples were taken on the 126th day of the experiment. Tendon samples taken from the sheep treated with RPWT+ADSCs showed lower cellularity and the highest number of thick collage fibers. Samples taken from the sheep treated with RPWT+PRP showed an elevated rate of neovascularization. Addition of the RPWT to ADSCs injections in the treatment of induced Achilles tendinopathy in sheep resulted in good quality of the tissue regeneration. Dual therapy with RPWT+PRP injection can lead to neovascularization in the tendon tissue.</description><identifier>ISSN: 1505-1773</identifier><identifier>EISSN: 2300-2557</identifier><identifier>DOI: 10.24425/pjvs.2019.131405</identifier><identifier>PMID: 31867928</identifier><language>eng</language><publisher>Germany: Polish Academy of Sciences, Committee of Veterinary Sciences</publisher><subject>Animal euthanasia ; Animals ; Autografts ; Collagen ; Collagenase ; Collagenases - toxicity ; Drug dosages ; Enzymes ; Experiments ; Injection ; Medical research ; Mesenchymal Stem Cells ; Platelet-Rich Plasma ; Platelets ; Pressure ; Sheep ; Sheep Diseases - etiology ; Sheep Diseases - therapy ; Stem cell transplantation ; Stem cells ; Tendinopathy - chemically induced ; Tendinopathy - therapy ; Tendinopathy - veterinary ; Tendons ; Ultrasonic imaging ; Ultrasonic Therapy - adverse effects ; Ultrasonic Therapy - veterinary ; Ultrasound ; Vascularization ; Veins & arteries</subject><ispartof>Polish journal of veterinary sciences, 2019-12, Vol.22 (4), p.743-751</ispartof><rights>Copyright© by the Polish Academy of Sciences.</rights><rights>Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-adc6f29ef9f5634d417c6bdd85d314ec2e13dea2e0f96cc526cd3908e94f0f13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31867928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Facon-Poroszewska, M</creatorcontrib><creatorcontrib>Kiełbowicz, Z</creatorcontrib><creatorcontrib>Prządka, P</creatorcontrib><title>Influence of Radial Pressure Wave Therapy (RPWT) on collagenase-induced Achilles tendinopathy treated with Platelet Rich Plasma and Autologous Adipose Derived Stem Cells</title><title>Polish journal of veterinary sciences</title><addtitle>Pol J Vet Sci</addtitle><description>Tendinopathy treatment poses a current challenge for sport medicine due to unique physiology and biomechanics of tendons. The goal of this work was to compare the efficacy of the addition of the radial pressure wave therapy (RPWT) treatment to injection of autologous Adipose Derived Stem Cells (ADSCs) or Platelet Rich Plasma (PRP) in the therapeutic procedure for collagenase induced Achilles tendinopathy in sheep. 14 sheep (aged 5 and 6 years, Polish Mountain Sheep breed, weight 60-70 kg) were injected bacterial collagenase type 1A-S (Clostridium histolyticum, C-5894, Sigma Aldrich, Poznań, Poland) bilaterally to Achilles tendons. Subsequently, the animals were injected with PRP (7 sheep) or ADSCs (7 sheep) to previously induced tendinopathy foci. Left limbs of all the animals were additionally treated with RPWT focused above the tendinopathy origins. Treatment progress was controlled by ultrasound scans, and tendon samples were taken on the 126th day of the experiment. Tendon samples taken from the sheep treated with RPWT+ADSCs showed lower cellularity and the highest number of thick collage fibers. Samples taken from the sheep treated with RPWT+PRP showed an elevated rate of neovascularization. Addition of the RPWT to ADSCs injections in the treatment of induced Achilles tendinopathy in sheep resulted in good quality of the tissue regeneration. Dual therapy with RPWT+PRP injection can lead to neovascularization in the tendon tissue.</description><subject>Animal euthanasia</subject><subject>Animals</subject><subject>Autografts</subject><subject>Collagen</subject><subject>Collagenase</subject><subject>Collagenases - toxicity</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Injection</subject><subject>Medical research</subject><subject>Mesenchymal Stem Cells</subject><subject>Platelet-Rich Plasma</subject><subject>Platelets</subject><subject>Pressure</subject><subject>Sheep</subject><subject>Sheep Diseases - etiology</subject><subject>Sheep Diseases - therapy</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Tendinopathy - chemically induced</subject><subject>Tendinopathy - therapy</subject><subject>Tendinopathy - veterinary</subject><subject>Tendons</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic Therapy - adverse effects</subject><subject>Ultrasonic Therapy - veterinary</subject><subject>Ultrasound</subject><subject>Vascularization</subject><subject>Veins & arteries</subject><issn>1505-1773</issn><issn>2300-2557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNo1kMmOEzEQhi0EYsLAA3BBJXGBQwcvbXf3MQrbSCMRhUhzjDx2eeLIsRvbHZRH4i1pYDhVlepfpI-Q14wuedty-WE8nsuSUzYsmWAtlU_IggtKGy5l95QsmKSyYV0nrsiLUo6UqkH06jm5EqxX3cD7Bfl1E12YMBqE5GCrrdcBNhlLmTLCnT4j7A6Y9XiBd9vN3e49pAgmhaAfMOqCjY92MmhhZQ4-BCxQMVof06jr4QI1o67z96evB9iEeQ9YYevN36ucNOg4e6eaQnpIU4GV9WMqCB8x-_Ns_F7xBGsMobwkz5wOBV89zmuy-_xpt_7a3H77crNe3TZGCFobbY1yfEA3OKlEa1vWGXVvbS_tjAgNRyYsao7UDcoYyZWxYqA9Dq2jjolr8vZf7JjTjwlL3R_TlOPcuOdCccZn7n9Ubx5V0_0J7X7M_qTzZf8frPgN-Sl-OQ</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Facon-Poroszewska, M</creator><creator>Kiełbowicz, Z</creator><creator>Prządka, P</creator><general>Polish Academy of Sciences, Committee of Veterinary Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>201912</creationdate><title>Influence of Radial Pressure Wave Therapy (RPWT) on collagenase-induced Achilles tendinopathy treated with Platelet Rich Plasma and Autologous Adipose Derived Stem Cells</title><author>Facon-Poroszewska, M ; Kiełbowicz, Z ; Prządka, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-adc6f29ef9f5634d417c6bdd85d314ec2e13dea2e0f96cc526cd3908e94f0f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal euthanasia</topic><topic>Animals</topic><topic>Autografts</topic><topic>Collagen</topic><topic>Collagenase</topic><topic>Collagenases - toxicity</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Experiments</topic><topic>Injection</topic><topic>Medical research</topic><topic>Mesenchymal Stem Cells</topic><topic>Platelet-Rich Plasma</topic><topic>Platelets</topic><topic>Pressure</topic><topic>Sheep</topic><topic>Sheep Diseases - etiology</topic><topic>Sheep Diseases - therapy</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Tendinopathy - chemically induced</topic><topic>Tendinopathy - therapy</topic><topic>Tendinopathy - veterinary</topic><topic>Tendons</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic Therapy - adverse effects</topic><topic>Ultrasonic Therapy - veterinary</topic><topic>Ultrasound</topic><topic>Vascularization</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Facon-Poroszewska, M</creatorcontrib><creatorcontrib>Kiełbowicz, Z</creatorcontrib><creatorcontrib>Prządka, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Polish journal of veterinary sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Facon-Poroszewska, M</au><au>Kiełbowicz, Z</au><au>Prządka, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Radial Pressure Wave Therapy (RPWT) on collagenase-induced Achilles tendinopathy treated with Platelet Rich Plasma and Autologous Adipose Derived Stem Cells</atitle><jtitle>Polish journal of veterinary sciences</jtitle><addtitle>Pol J Vet Sci</addtitle><date>2019-12</date><risdate>2019</risdate><volume>22</volume><issue>4</issue><spage>743</spage><epage>751</epage><pages>743-751</pages><issn>1505-1773</issn><eissn>2300-2557</eissn><abstract>Tendinopathy treatment poses a current challenge for sport medicine due to unique physiology and biomechanics of tendons. The goal of this work was to compare the efficacy of the addition of the radial pressure wave therapy (RPWT) treatment to injection of autologous Adipose Derived Stem Cells (ADSCs) or Platelet Rich Plasma (PRP) in the therapeutic procedure for collagenase induced Achilles tendinopathy in sheep. 14 sheep (aged 5 and 6 years, Polish Mountain Sheep breed, weight 60-70 kg) were injected bacterial collagenase type 1A-S (Clostridium histolyticum, C-5894, Sigma Aldrich, Poznań, Poland) bilaterally to Achilles tendons. Subsequently, the animals were injected with PRP (7 sheep) or ADSCs (7 sheep) to previously induced tendinopathy foci. Left limbs of all the animals were additionally treated with RPWT focused above the tendinopathy origins. Treatment progress was controlled by ultrasound scans, and tendon samples were taken on the 126th day of the experiment. Tendon samples taken from the sheep treated with RPWT+ADSCs showed lower cellularity and the highest number of thick collage fibers. Samples taken from the sheep treated with RPWT+PRP showed an elevated rate of neovascularization. Addition of the RPWT to ADSCs injections in the treatment of induced Achilles tendinopathy in sheep resulted in good quality of the tissue regeneration. Dual therapy with RPWT+PRP injection can lead to neovascularization in the tendon tissue.</abstract><cop>Germany</cop><pub>Polish Academy of Sciences, Committee of Veterinary Sciences</pub><pmid>31867928</pmid><doi>10.24425/pjvs.2019.131405</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Polish journal of veterinary sciences, 2019-12, Vol.22 (4), p.743-751 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animal euthanasia Animals Autografts Collagen Collagenase Collagenases - toxicity Drug dosages Enzymes Experiments Injection Medical research Mesenchymal Stem Cells Platelet-Rich Plasma Platelets Pressure Sheep Sheep Diseases - etiology Sheep Diseases - therapy Stem cell transplantation Stem cells Tendinopathy - chemically induced Tendinopathy - therapy Tendinopathy - veterinary Tendons Ultrasonic imaging Ultrasonic Therapy - adverse effects Ultrasonic Therapy - veterinary Ultrasound Vascularization Veins & arteries |
| title | Influence of Radial Pressure Wave Therapy (RPWT) on collagenase-induced Achilles tendinopathy treated with Platelet Rich Plasma and Autologous Adipose Derived Stem Cells |
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