Risk Analysis of Aseptic Meningitis after Measles-Mumps-Rubella Vaccination in Korean Children by Using a Case-Crossover Design
Epidemiologic study of a vaccine’s adverse events is not easy; so many countries have no reliable data. Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific...
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| Veröffentlicht in: | American journal of epidemiology 2003-01, Vol.157 (2), p.158-165 |
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| creator | Ki, Moran Park, Taesung Yi, Sung Gon Oh, Jin Kyoung Choi, BoYoul |
| description | Epidemiologic study of a vaccine’s adverse events is not easy; so many countries have no reliable data. Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific strains. The authors used a case-crossover design to estimate the relative risk of aseptic meningitis in children after receiving the measles-mumps-rubella vaccine in Korea. Study subjects were hospitalized children aged 8–36 months who had aseptic meningitis in 1998. Cases were confirmed by hospital chart reviews using previously defined criteria. Through a telephone survey, the authors obtained vaccination date and place information from parents’ vaccination records. Study results showed that no significant risk was associated with the Jeryl Lynn or Rubini strain of the vaccine (relative risk = 0.6, 95% confidence interval (CI): 0.18, 1.97). For the Urabe or Hoshino strain, the relative risk was 5.5 (95% CI: 2.6, 11.8); the risk increased in the third week after vaccination (relative risk = 15.6, 95% CI: 5.9, 41.2) and was elevated until the sixth week. The case-crossover design was useful in confirming the risk of acute adverse events after receiving vaccines. |
| doi_str_mv | 10.1093/aje/kwf167 |
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Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific strains. The authors used a case-crossover design to estimate the relative risk of aseptic meningitis in children after receiving the measles-mumps-rubella vaccine in Korea. Study subjects were hospitalized children aged 8–36 months who had aseptic meningitis in 1998. Cases were confirmed by hospital chart reviews using previously defined criteria. Through a telephone survey, the authors obtained vaccination date and place information from parents’ vaccination records. Study results showed that no significant risk was associated with the Jeryl Lynn or Rubini strain of the vaccine (relative risk = 0.6, 95% confidence interval (CI): 0.18, 1.97). For the Urabe or Hoshino strain, the relative risk was 5.5 (95% CI: 2.6, 11.8); the risk increased in the third week after vaccination (relative risk = 15.6, 95% CI: 5.9, 41.2) and was elevated until the sixth week. The case-crossover design was useful in confirming the risk of acute adverse events after receiving vaccines.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>EISSN: 0002-9262</identifier><identifier>DOI: 10.1093/aje/kwf167</identifier><identifier>PMID: 12522023</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>aseptic ; Biological and medical sciences ; child ; Child, Preschool ; confidence interval ; Confidence Intervals ; Cross-Over Studies ; Epidemiologic Methods ; epidemiologic research design ; Epidemiology. Vaccinations ; Female ; General aspects ; Hospitalization ; hospitalized ; Humans ; Infant ; Infectious diseases ; Korea - epidemiology ; Male ; measles-mumps-rubella ; Measles-Mumps-Rubella Vaccine - adverse effects ; Medical Records ; Medical sciences ; meningitis ; Meningitis, Aseptic - chemically induced ; Meningitis, Aseptic - epidemiology ; MMR ; mumps vaccine ; relative risk ; Risk ; Seasons ; Tropical medicine ; vaccines</subject><ispartof>American journal of epidemiology, 2003-01, Vol.157 (2), p.158-165</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jan 15, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-63ce1567e86ad4341b8937783a5976225a8c27e79aa133f867983f7ffcba06373</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14441372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12522023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ki, Moran</creatorcontrib><creatorcontrib>Park, Taesung</creatorcontrib><creatorcontrib>Yi, Sung Gon</creatorcontrib><creatorcontrib>Oh, Jin Kyoung</creatorcontrib><creatorcontrib>Choi, BoYoul</creatorcontrib><title>Risk Analysis of Aseptic Meningitis after Measles-Mumps-Rubella Vaccination in Korean Children by Using a Case-Crossover Design</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>Epidemiologic study of a vaccine’s adverse events is not easy; so many countries have no reliable data. Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific strains. The authors used a case-crossover design to estimate the relative risk of aseptic meningitis in children after receiving the measles-mumps-rubella vaccine in Korea. Study subjects were hospitalized children aged 8–36 months who had aseptic meningitis in 1998. Cases were confirmed by hospital chart reviews using previously defined criteria. Through a telephone survey, the authors obtained vaccination date and place information from parents’ vaccination records. Study results showed that no significant risk was associated with the Jeryl Lynn or Rubini strain of the vaccine (relative risk = 0.6, 95% confidence interval (CI): 0.18, 1.97). For the Urabe or Hoshino strain, the relative risk was 5.5 (95% CI: 2.6, 11.8); the risk increased in the third week after vaccination (relative risk = 15.6, 95% CI: 5.9, 41.2) and was elevated until the sixth week. The case-crossover design was useful in confirming the risk of acute adverse events after receiving vaccines.</description><subject>aseptic</subject><subject>Biological and medical sciences</subject><subject>child</subject><subject>Child, Preschool</subject><subject>confidence interval</subject><subject>Confidence Intervals</subject><subject>Cross-Over Studies</subject><subject>Epidemiologic Methods</subject><subject>epidemiologic research design</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization</subject><subject>hospitalized</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Korea - epidemiology</subject><subject>Male</subject><subject>measles-mumps-rubella</subject><subject>Measles-Mumps-Rubella Vaccine - adverse effects</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>meningitis</subject><subject>Meningitis, Aseptic - chemically induced</subject><subject>Meningitis, Aseptic - epidemiology</subject><subject>MMR</subject><subject>mumps vaccine</subject><subject>relative risk</subject><subject>Risk</subject><subject>Seasons</subject><subject>Tropical medicine</subject><subject>vaccines</subject><issn>0002-9262</issn><issn>1476-6256</issn><issn>0002-9262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1vEzEQhi0EoqFw4QcgC4kL0lJ_7Nq7x2j5CGorpIhGqBdr1rGLk4039ewCOfHXcZWInkaaefTMzEvIa84-cNbIC9i4i-1vz5V-Qma81KpQolJPyYwxJopGKHFGXiBuGOO8qdhzcsZFJQQTckb-LgNu6TxCf8CAdPB0jm4_BkuvXQzxLoy5C350KTcAe4fF9bTbY7GcOtf3QFdgbYgwhiHSEOnlkBxE2v4M_Tq5SLsDvcHsoUBbQFe0aUAcfmXdR4fhLr4kzzz06F6d6jm5-fzpe7sorr59-drOrwordT0WSlrHK6VdrWBdypJ3dSO1riVUjVZCVFBboZ1uALiUvla6qaXX3tsOmJJanpO3R-8-DfeTw9Fshinlt9EImR2S8SpD74-QfbgyOW_2KewgHQxn5iFqk6M2x6gz_OZknLqdWz-ip2wz8O4EAFrofYJoAz5yZVlyqUXmiiMXcHR__s8hbU1eoyuz-HFrLpfsdrWQK8PkPx6RlmY</recordid><startdate>20030115</startdate><enddate>20030115</enddate><creator>Ki, Moran</creator><creator>Park, Taesung</creator><creator>Yi, Sung Gon</creator><creator>Oh, Jin Kyoung</creator><creator>Choi, BoYoul</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20030115</creationdate><title>Risk Analysis of Aseptic Meningitis after Measles-Mumps-Rubella Vaccination in Korean Children by Using a Case-Crossover Design</title><author>Ki, Moran ; Park, Taesung ; Yi, Sung Gon ; Oh, Jin Kyoung ; Choi, BoYoul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-63ce1567e86ad4341b8937783a5976225a8c27e79aa133f867983f7ffcba06373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>aseptic</topic><topic>Biological and medical sciences</topic><topic>child</topic><topic>Child, Preschool</topic><topic>confidence interval</topic><topic>Confidence Intervals</topic><topic>Cross-Over Studies</topic><topic>Epidemiologic Methods</topic><topic>epidemiologic research design</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization</topic><topic>hospitalized</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Korea - epidemiology</topic><topic>Male</topic><topic>measles-mumps-rubella</topic><topic>Measles-Mumps-Rubella Vaccine - adverse effects</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>meningitis</topic><topic>Meningitis, Aseptic - chemically induced</topic><topic>Meningitis, Aseptic - epidemiology</topic><topic>MMR</topic><topic>mumps vaccine</topic><topic>relative risk</topic><topic>Risk</topic><topic>Seasons</topic><topic>Tropical medicine</topic><topic>vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ki, Moran</creatorcontrib><creatorcontrib>Park, Taesung</creatorcontrib><creatorcontrib>Yi, Sung Gon</creatorcontrib><creatorcontrib>Oh, Jin Kyoung</creatorcontrib><creatorcontrib>Choi, BoYoul</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ki, Moran</au><au>Park, Taesung</au><au>Yi, Sung Gon</au><au>Oh, Jin Kyoung</au><au>Choi, BoYoul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Analysis of Aseptic Meningitis after Measles-Mumps-Rubella Vaccination in Korean Children by Using a Case-Crossover Design</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2003-01-15</date><risdate>2003</risdate><volume>157</volume><issue>2</issue><spage>158</spage><epage>165</epage><pages>158-165</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><eissn>0002-9262</eissn><coden>AJEPAS</coden><abstract>Epidemiologic study of a vaccine’s adverse events is not easy; so many countries have no reliable data. Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific strains. The authors used a case-crossover design to estimate the relative risk of aseptic meningitis in children after receiving the measles-mumps-rubella vaccine in Korea. Study subjects were hospitalized children aged 8–36 months who had aseptic meningitis in 1998. Cases were confirmed by hospital chart reviews using previously defined criteria. Through a telephone survey, the authors obtained vaccination date and place information from parents’ vaccination records. Study results showed that no significant risk was associated with the Jeryl Lynn or Rubini strain of the vaccine (relative risk = 0.6, 95% confidence interval (CI): 0.18, 1.97). For the Urabe or Hoshino strain, the relative risk was 5.5 (95% CI: 2.6, 11.8); the risk increased in the third week after vaccination (relative risk = 15.6, 95% CI: 5.9, 41.2) and was elevated until the sixth week. The case-crossover design was useful in confirming the risk of acute adverse events after receiving vaccines.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>12522023</pmid><doi>10.1093/aje/kwf167</doi><tpages>8</tpages></addata></record> |
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| subjects | aseptic Biological and medical sciences child Child, Preschool confidence interval Confidence Intervals Cross-Over Studies Epidemiologic Methods epidemiologic research design Epidemiology. Vaccinations Female General aspects Hospitalization hospitalized Humans Infant Infectious diseases Korea - epidemiology Male measles-mumps-rubella Measles-Mumps-Rubella Vaccine - adverse effects Medical Records Medical sciences meningitis Meningitis, Aseptic - chemically induced Meningitis, Aseptic - epidemiology MMR mumps vaccine relative risk Risk Seasons Tropical medicine vaccines |
| title | Risk Analysis of Aseptic Meningitis after Measles-Mumps-Rubella Vaccination in Korean Children by Using a Case-Crossover Design |
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