Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan
— Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined...
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| Veröffentlicht in: | Cell and tissue biology 2019, Vol.13 (6), p.463-469 |
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| container_title | Cell and tissue biology |
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| creator | Popryadukhin, P. V. Yukina, G. Y. Dobrovolskaya, I. P. Ivankova, E. M. Yudin, V. E. |
| description | —
Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined by histological and immunohistochemical methods in vivo after1, 2, 6, 12, 24, 36, and 48 weeks. The role of CD68
+
cells, mainly giant multinucleated of foreign body cells, has been investigated. Chronic aseptic inflammation is not accompanied by the activation of mast cells. It shows the bioinertness of the matrix material and allows us to recommend this matrix for use in regenerative medicine, tissue engineering, and cell transplantology. |
| doi_str_mv | 10.1134/S1990519X19060087 |
| format | Article |
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Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined by histological and immunohistochemical methods in vivo after1, 2, 6, 12, 24, 36, and 48 weeks. The role of CD68
+
cells, mainly giant multinucleated of foreign body cells, has been investigated. Chronic aseptic inflammation is not accompanied by the activation of mast cells. It shows the bioinertness of the matrix material and allows us to recommend this matrix for use in regenerative medicine, tissue engineering, and cell transplantology.</description><identifier>ISSN: 1990-519X</identifier><identifier>EISSN: 1990-5203</identifier><identifier>DOI: 10.1134/S1990519X19060087</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biomedical and Life Sciences ; Cell activation ; Cell Biology ; Chitosan ; Freeze drying ; Life Sciences ; Mast cells ; Regenerative medicine ; Tissue engineering</subject><ispartof>Cell and tissue biology, 2019, Vol.13 (6), p.463-469</ispartof><rights>Pleiades Publishing, Ltd. 2019</rights><rights>2019© Pleiades Publishing, Ltd. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1137-ef96c1e4439222289afc32ece0bf3e38d4290df1d17b890c8f9fe94bab8c56a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1990519X19060087$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1990519X19060087$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Popryadukhin, P. V.</creatorcontrib><creatorcontrib>Yukina, G. Y.</creatorcontrib><creatorcontrib>Dobrovolskaya, I. P.</creatorcontrib><creatorcontrib>Ivankova, E. M.</creatorcontrib><creatorcontrib>Yudin, V. E.</creatorcontrib><title>Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan</title><title>Cell and tissue biology</title><addtitle>Cell Tiss. Biol</addtitle><description>—
Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined by histological and immunohistochemical methods in vivo after1, 2, 6, 12, 24, 36, and 48 weeks. The role of CD68
+
cells, mainly giant multinucleated of foreign body cells, has been investigated. Chronic aseptic inflammation is not accompanied by the activation of mast cells. It shows the bioinertness of the matrix material and allows us to recommend this matrix for use in regenerative medicine, tissue engineering, and cell transplantology.</description><subject>Biomedical and Life Sciences</subject><subject>Cell activation</subject><subject>Cell Biology</subject><subject>Chitosan</subject><subject>Freeze drying</subject><subject>Life Sciences</subject><subject>Mast cells</subject><subject>Regenerative medicine</subject><subject>Tissue engineering</subject><issn>1990-519X</issn><issn>1990-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1UEtLxDAQDqLguvoDvAU8VzNN2iZHtz5hFwUVvJU0nbhdus2atKD_3iyreBDnMsP3mmEIOQV2DsDFxRMoxTJQr6BYzpgs9shkCyVZyvj-zxz5Q3IUwopFkQA2IfMSu27stKcLNEvdt2EdqLN01jqPwfnN0Lp-C2j66LwbA-VXdKEH337QmQ7Y0EiXy3ZwQffH5MDqLuDJd5-Sl5vr5_IumT_c3peX88TEW4sErcoNoBBcpbGk0tbwFA2y2nLkshGpYo2FBopaKmakVRaVqHUtTZbrgk_J2S534937iGGoVm70fVxZpTxTQgLL8qiCncp4F4JHW218u9b-swJWbZ9W_Xla9KQ7T4ja_g39b_L_pi8wi22d</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Popryadukhin, P. V.</creator><creator>Yukina, G. Y.</creator><creator>Dobrovolskaya, I. P.</creator><creator>Ivankova, E. M.</creator><creator>Yudin, V. E.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2019</creationdate><title>Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan</title><author>Popryadukhin, P. V. ; Yukina, G. Y. ; Dobrovolskaya, I. P. ; Ivankova, E. M. ; Yudin, V. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1137-ef96c1e4439222289afc32ece0bf3e38d4290df1d17b890c8f9fe94bab8c56a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomedical and Life Sciences</topic><topic>Cell activation</topic><topic>Cell Biology</topic><topic>Chitosan</topic><topic>Freeze drying</topic><topic>Life Sciences</topic><topic>Mast cells</topic><topic>Regenerative medicine</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popryadukhin, P. V.</creatorcontrib><creatorcontrib>Yukina, G. Y.</creatorcontrib><creatorcontrib>Dobrovolskaya, I. P.</creatorcontrib><creatorcontrib>Ivankova, E. M.</creatorcontrib><creatorcontrib>Yudin, V. E.</creatorcontrib><collection>CrossRef</collection><jtitle>Cell and tissue biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popryadukhin, P. V.</au><au>Yukina, G. Y.</au><au>Dobrovolskaya, I. P.</au><au>Ivankova, E. M.</au><au>Yudin, V. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan</atitle><jtitle>Cell and tissue biology</jtitle><stitle>Cell Tiss. Biol</stitle><date>2019</date><risdate>2019</risdate><volume>13</volume><issue>6</issue><spage>463</spage><epage>469</epage><pages>463-469</pages><issn>1990-519X</issn><eissn>1990-5203</eissn><abstract>—
Highly porous three-dimensional (3D) cylindrical matrices with a diameter of 1.3 mm were obtained by lyophilization of the chitosan solution. The matrix was implanted into rat muscle tissue and after12 months underwent complete resorption. Cellular mechanisms of matrix bioresorption were examined by histological and immunohistochemical methods in vivo after1, 2, 6, 12, 24, 36, and 48 weeks. The role of CD68
+
cells, mainly giant multinucleated of foreign body cells, has been investigated. Chronic aseptic inflammation is not accompanied by the activation of mast cells. It shows the bioinertness of the matrix material and allows us to recommend this matrix for use in regenerative medicine, tissue engineering, and cell transplantology.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1990519X19060087</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cell and tissue biology, 2019, Vol.13 (6), p.463-469 |
| issn | 1990-519X 1990-5203 |
| language | eng |
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| source | SpringerNature Complete Journals |
| subjects | Biomedical and Life Sciences Cell activation Cell Biology Chitosan Freeze drying Life Sciences Mast cells Regenerative medicine Tissue engineering |
| title | Cellular Mechanisms of Bioresorption of a Porous 3D Matrix Based on Chitosan |
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