Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury
Glutaric aciduria type 1 (GA1) is an inborn error of organic acid metabolism, where the brain is the principal organ affected with exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A 2-year-old boy with GA1 and delayed developmental milestones had an acute neurological crisis lea...
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| Veröffentlicht in: | Journal of postgraduate medicine 2008-01, Vol.54 (1), p.35-36 |
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| creator | Mukhopadhyay, C Dey, A Bairy, I |
| description | Glutaric aciduria type 1 (GA1) is an inborn error of organic acid
metabolism, where the brain is the principal organ affected with
exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A
2-year-old boy with GA1 and delayed developmental milestones had an
acute neurological crisis leading to massive brain abscess with
Citrobacter freundii infection, a rare cause of neonatal meningitis
and often associated with brain abscess. Both 3-OHGA and C. freundii
can damage the blood-brain barrier and can cause significant trauma
which demands immediate and appropriate management. Encephalopathic
manifestations of GA1 may consequently increase the risk of meningeal
infection and it has not been previously documented. |
| doi_str_mv | 10.4103/0022-3859.39189 |
| format | Article |
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metabolism, where the brain is the principal organ affected with
exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A
2-year-old boy with GA1 and delayed developmental milestones had an
acute neurological crisis leading to massive brain abscess with
Citrobacter freundii infection, a rare cause of neonatal meningitis
and often associated with brain abscess. Both 3-OHGA and C. freundii
can damage the blood-brain barrier and can cause significant trauma
which demands immediate and appropriate management. Encephalopathic
manifestations of GA1 may consequently increase the risk of meningeal
infection and it has not been previously documented.</description><identifier>ISSN: 0022-3859</identifier><identifier>EISSN: 0972-2823</identifier><identifier>DOI: 10.4103/0022-3859.39189</identifier><identifier>PMID: 18296804</identifier><language>eng</language><publisher>India: Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Bacteria ; Bacterial infections ; Brain Abscess - drug therapy ; Brain Abscess - etiology ; Brain Abscess - microbiology ; Brain abscess, Citrobacter freundii, glutaric aciduria type 1 ; Brain Diseases, Metabolic, Inborn - diagnosis ; Brain Diseases, Metabolic, Inborn - genetics ; Brain Diseases, Metabolic, Inborn - metabolism ; Case studies ; Central nervous system ; Child, Preschool ; Children & youth ; Citrobacter freundii - isolation & purification ; Complications and side effects ; Diagnosis ; Diagnosis, Differential ; Enterobacteriaceae Infections - complications ; Enterobacteriaceae Infections - drug therapy ; Enterobacteriaceae Infections - microbiology ; Genetic disorders ; Glutarates - metabolism ; Glutarates - urine ; Health aspects ; Humans ; Infections ; Male ; Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics ; Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism ; Risk factors</subject><ispartof>Journal of postgraduate medicine, 2008-01, Vol.54 (1), p.35-36</ispartof><rights>Copyright 2008 Journal of Postgraduate Medicine.</rights><rights>COPYRIGHT 2008 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Jan-Mar 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b361t-43d6a1b321fd47b7ed055d31b00eff39fb59939312e9ee1bc17e12a1b7f346d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79426</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18296804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukhopadhyay, C</creatorcontrib><creatorcontrib>Dey, A</creatorcontrib><creatorcontrib>Bairy, I</creatorcontrib><title>Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury</title><title>Journal of postgraduate medicine</title><addtitle>J Postgrad Med</addtitle><description>Glutaric aciduria type 1 (GA1) is an inborn error of organic acid
metabolism, where the brain is the principal organ affected with
exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A
2-year-old boy with GA1 and delayed developmental milestones had an
acute neurological crisis leading to massive brain abscess with
Citrobacter freundii infection, a rare cause of neonatal meningitis
and often associated with brain abscess. Both 3-OHGA and C. freundii
can damage the blood-brain barrier and can cause significant trauma
which demands immediate and appropriate management. Encephalopathic
manifestations of GA1 may consequently increase the risk of meningeal
infection and it has not been previously documented.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Brain Abscess - drug therapy</subject><subject>Brain Abscess - etiology</subject><subject>Brain Abscess - microbiology</subject><subject>Brain abscess, Citrobacter freundii, glutaric aciduria type 1</subject><subject>Brain Diseases, Metabolic, Inborn - diagnosis</subject><subject>Brain Diseases, Metabolic, Inborn - genetics</subject><subject>Brain Diseases, Metabolic, Inborn - metabolism</subject><subject>Case studies</subject><subject>Central nervous system</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Citrobacter freundii - isolation & purification</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Enterobacteriaceae Infections - complications</subject><subject>Enterobacteriaceae Infections - drug therapy</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Genetic disorders</subject><subject>Glutarates - metabolism</subject><subject>Glutarates - urine</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics</subject><subject>Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism</subject><subject>Risk factors</subject><issn>0022-3859</issn><issn>0972-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1vGyEQhlHVqHacnnurVr2vw8B-0ZtltU2kSD00OSM-Bgtrvbgse_C_L67t-GKBxGh4XmaYl5AvQJcVUP5IKWMl72qx5AI68YHMqWhZyTrGP-b4cjsj9-O4pRSapuKfyAw6JpqOVnPyZ-1TDFqZhLFwEafBel_4waFJPgw5Kjb9lFT0plDG2yl6VaTDHgv4Xqys9cMmM-PUpyKFHG2neHggd071I34-nwvy9vPH6_qpfPn963m9eik1byCVFbeNAs0ZOFu1ukVL69py0JSic1w4XQvBBQeGAhG0gRaBZUXreNXYli_It9O7-xj-TjgmuQ1THHJJyXgtoM5TyFB5gjaqR5k_FlJUZoMDRtWHAZ3P6RW0dVVRVtPML2_weVnceXNT8HgSmBjGMaKT--h3Kh4kUHk0SR5tkEcb5H-TsuLrue9J79Be-bMr1x60D70f8J0wefryktzu86YdzSX-ATdPm_U</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Mukhopadhyay, C</creator><creator>Dey, A</creator><creator>Bairy, I</creator><general>Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</general><general>Medknow Publications and Media Pvt. 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administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Brain Abscess - drug therapy</topic><topic>Brain Abscess - etiology</topic><topic>Brain Abscess - microbiology</topic><topic>Brain abscess, Citrobacter freundii, glutaric aciduria type 1</topic><topic>Brain Diseases, Metabolic, Inborn - diagnosis</topic><topic>Brain Diseases, Metabolic, Inborn - genetics</topic><topic>Brain Diseases, Metabolic, Inborn - metabolism</topic><topic>Case studies</topic><topic>Central nervous system</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Citrobacter freundii - isolation & purification</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Enterobacteriaceae Infections - complications</topic><topic>Enterobacteriaceae Infections - drug therapy</topic><topic>Enterobacteriaceae Infections - microbiology</topic><topic>Genetic disorders</topic><topic>Glutarates - metabolism</topic><topic>Glutarates - urine</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics</topic><topic>Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukhopadhyay, C</creatorcontrib><creatorcontrib>Dey, A</creatorcontrib><creatorcontrib>Bairy, I</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of postgraduate medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukhopadhyay, C</au><au>Dey, A</au><au>Bairy, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury</atitle><jtitle>Journal of postgraduate medicine</jtitle><addtitle>J Postgrad Med</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>54</volume><issue>1</issue><spage>35</spage><epage>36</epage><pages>35-36</pages><issn>0022-3859</issn><eissn>0972-2823</eissn><abstract>Glutaric aciduria type 1 (GA1) is an inborn error of organic acid
metabolism, where the brain is the principal organ affected with
exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A
2-year-old boy with GA1 and delayed developmental milestones had an
acute neurological crisis leading to massive brain abscess with
Citrobacter freundii infection, a rare cause of neonatal meningitis
and often associated with brain abscess. Both 3-OHGA and C. freundii
can damage the blood-brain barrier and can cause significant trauma
which demands immediate and appropriate management. Encephalopathic
manifestations of GA1 may consequently increase the risk of meningeal
infection and it has not been previously documented.</abstract><cop>India</cop><pub>Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India</pub><pmid>18296804</pmid><doi>10.4103/0022-3859.39189</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3859 |
| ispartof | Journal of postgraduate medicine, 2008-01, Vol.54 (1), p.35-36 |
| issn | 0022-3859 0972-2823 |
| language | eng |
| recordid | cdi_proquest_journals_235915823 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Bacteria Bacterial infections Brain Abscess - drug therapy Brain Abscess - etiology Brain Abscess - microbiology Brain abscess, Citrobacter freundii, glutaric aciduria type 1 Brain Diseases, Metabolic, Inborn - diagnosis Brain Diseases, Metabolic, Inborn - genetics Brain Diseases, Metabolic, Inborn - metabolism Case studies Central nervous system Child, Preschool Children & youth Citrobacter freundii - isolation & purification Complications and side effects Diagnosis Diagnosis, Differential Enterobacteriaceae Infections - complications Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - microbiology Genetic disorders Glutarates - metabolism Glutarates - urine Health aspects Humans Infections Male Multiple Acyl Coenzyme A Dehydrogenase Deficiency - genetics Multiple Acyl Coenzyme A Dehydrogenase Deficiency - metabolism Risk factors |
| title | Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury |
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