Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration
The lignan enterolactone, a phytoestrogen, may protect against hormone-dependent cancers and cardiovascular diseases. It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether ser...
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| Veröffentlicht in: | American journal of epidemiology 2002-03, Vol.155 (5), p.472-477 |
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| creator | Kilkkinen, Annamari Pietinen, Pirjo Klaukka, Timo Virtamo, Jarmo Korhonen, Pasi Adlercreutz, Herman |
| description | The lignan enterolactone, a phytoestrogen, may protect against hormone-dependent cancers and cardiovascular diseases. It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether serum enterolactone concentration is affected by previous use of oral antimicrobials. Enterolactone was measured by time-resolved fluoroimmunoassay in 2,753 Finnish men and women aged 25–64 years who participated in a cross-sectional national survey in 1997. Background information was collected by self-administered questionnaire, and data on antimicrobial treatment were gathered from the nationwide prescription database of the Social Insurance Institution. Serum enterolactone concentration was significantly lower in those who had used oral antimicrobials up to 12–16 months before serum sampling than in nonusers (16.4 vs. 19.3 nmol/liter). The concentration was associated with the number of treatments and the time from the last treatment. Modest differences were present between various antimicrobials. The authors' findings support the crucial role of gut microflora in the metabolism of lignans. Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied. |
| doi_str_mv | 10.1093/aje/155.5.472 |
| format | Article |
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It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether serum enterolactone concentration is affected by previous use of oral antimicrobials. Enterolactone was measured by time-resolved fluoroimmunoassay in 2,753 Finnish men and women aged 25–64 years who participated in a cross-sectional national survey in 1997. Background information was collected by self-administered questionnaire, and data on antimicrobial treatment were gathered from the nationwide prescription database of the Social Insurance Institution. Serum enterolactone concentration was significantly lower in those who had used oral antimicrobials up to 12–16 months before serum sampling than in nonusers (16.4 vs. 19.3 nmol/liter). The concentration was associated with the number of treatments and the time from the last treatment. Modest differences were present between various antimicrobials. The authors' findings support the crucial role of gut microflora in the metabolism of lignans. Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>EISSN: 0002-9262</identifier><identifier>DOI: 10.1093/aje/155.5.472</identifier><identifier>PMID: 11867359</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - blood ; Administration, Oral ; Adult ; Anti-Bacterial Agents - adverse effects ; Antibacterial agents ; antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; bacteria ; Biological and medical sciences ; biological markers ; Biomarkers - analysis ; BMI ; body mass index ; Chronic Disease ; confidence interval ; Cross-Sectional Studies ; Digestive System - microbiology ; drug therapy ; Female ; Humans ; intestines ; lignans ; Lignans - blood ; Medical sciences ; metabolism ; Middle Aged ; Pharmacology. Drug treatments ; Risk Factors ; standard deviation ; time-resolved fluoroimmunoassay ; TR-FIA</subject><ispartof>American journal of epidemiology, 2002-03, Vol.155 (5), p.472-477</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Mar 01, 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-16d52fbe3ab3704cc9c4b9f4dd0699d86fa0b1fba252b688a374c860b60a913e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13521798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11867359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilkkinen, Annamari</creatorcontrib><creatorcontrib>Pietinen, Pirjo</creatorcontrib><creatorcontrib>Klaukka, Timo</creatorcontrib><creatorcontrib>Virtamo, Jarmo</creatorcontrib><creatorcontrib>Korhonen, Pasi</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><title>Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration</title><title>American journal of epidemiology</title><addtitle>Am. J. Epidemiol</addtitle><description>The lignan enterolactone, a phytoestrogen, may protect against hormone-dependent cancers and cardiovascular diseases. It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether serum enterolactone concentration is affected by previous use of oral antimicrobials. Enterolactone was measured by time-resolved fluoroimmunoassay in 2,753 Finnish men and women aged 25–64 years who participated in a cross-sectional national survey in 1997. Background information was collected by self-administered questionnaire, and data on antimicrobial treatment were gathered from the nationwide prescription database of the Social Insurance Institution. Serum enterolactone concentration was significantly lower in those who had used oral antimicrobials up to 12–16 months before serum sampling than in nonusers (16.4 vs. 19.3 nmol/liter). The concentration was associated with the number of treatments and the time from the last treatment. Modest differences were present between various antimicrobials. The authors' findings support the crucial role of gut microflora in the metabolism of lignans. Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied.</description><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - blood</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibacterial agents</subject><subject>antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>bacteria</subject><subject>Biological and medical sciences</subject><subject>biological markers</subject><subject>Biomarkers - analysis</subject><subject>BMI</subject><subject>body mass index</subject><subject>Chronic Disease</subject><subject>confidence interval</subject><subject>Cross-Sectional Studies</subject><subject>Digestive System - microbiology</subject><subject>drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>intestines</subject><subject>lignans</subject><subject>Lignans - blood</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk Factors</subject><subject>standard deviation</subject><subject>time-resolved fluoroimmunoassay</subject><subject>TR-FIA</subject><issn>0002-9262</issn><issn>1476-6256</issn><issn>0002-9262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAYhoMobk6PXqUIHrvld5ujzs0JhQk6EC8hSRPo7NqZtKD_vZEVd_oO3_O9L98DwDWCUwQFmamtnSHGpmxKM3wCxohmPOWY8VMwhhDiVGCOR-AihC2ECAkGz8EIoZxnhIkxWG6CTVqXrL2qk_umq3aV8a2uVB2SR2u8VcGG5NX6fpcsms76tlamaxubzNvG2Kbzqqva5hKcuXhir4Y5AZvl4m2-Sov10_P8vkgNzUWXIl4y7LQlSpMMUmOEoVo4WpaQC1Hm3CmokdMKM6x5niuSUZNzqDlUAhFLJuD2kLv37VdvQye3be-bWCkxYbmgnIgIpQcofhKCt07ufbVT_kciKP-kyShNRmmSySgt8jdDaK93tjzSg6UI3A2ACkbVzqvGVOHIEYZRJvJjcRU6-_2_V_5TxqCMydX7hyzwwwsTvJCE_AI584OG</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Kilkkinen, Annamari</creator><creator>Pietinen, Pirjo</creator><creator>Klaukka, Timo</creator><creator>Virtamo, Jarmo</creator><creator>Korhonen, Pasi</creator><creator>Adlercreutz, Herman</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20020301</creationdate><title>Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration</title><author>Kilkkinen, Annamari ; Pietinen, Pirjo ; Klaukka, Timo ; Virtamo, Jarmo ; Korhonen, Pasi ; Adlercreutz, Herman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-16d52fbe3ab3704cc9c4b9f4dd0699d86fa0b1fba252b688a374c860b60a913e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - blood</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Antibacterial agents</topic><topic>antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>bacteria</topic><topic>Biological and medical sciences</topic><topic>biological markers</topic><topic>Biomarkers - analysis</topic><topic>BMI</topic><topic>body mass index</topic><topic>Chronic Disease</topic><topic>confidence interval</topic><topic>Cross-Sectional Studies</topic><topic>Digestive System - microbiology</topic><topic>drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>intestines</topic><topic>lignans</topic><topic>Lignans - blood</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk Factors</topic><topic>standard deviation</topic><topic>time-resolved fluoroimmunoassay</topic><topic>TR-FIA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilkkinen, Annamari</creatorcontrib><creatorcontrib>Pietinen, Pirjo</creatorcontrib><creatorcontrib>Klaukka, Timo</creatorcontrib><creatorcontrib>Virtamo, Jarmo</creatorcontrib><creatorcontrib>Korhonen, Pasi</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilkkinen, Annamari</au><au>Pietinen, Pirjo</au><au>Klaukka, Timo</au><au>Virtamo, Jarmo</au><au>Korhonen, Pasi</au><au>Adlercreutz, Herman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am. J. Epidemiol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>155</volume><issue>5</issue><spage>472</spage><epage>477</epage><pages>472-477</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><eissn>0002-9262</eissn><coden>AJEPAS</coden><abstract>The lignan enterolactone, a phytoestrogen, may protect against hormone-dependent cancers and cardiovascular diseases. It is produced by the intestinal microflora from dietary precursors. Because of the pronounced impact of antimicrobials on the intestinal microflora, the authors examined whether serum enterolactone concentration is affected by previous use of oral antimicrobials. Enterolactone was measured by time-resolved fluoroimmunoassay in 2,753 Finnish men and women aged 25–64 years who participated in a cross-sectional national survey in 1997. Background information was collected by self-administered questionnaire, and data on antimicrobial treatment were gathered from the nationwide prescription database of the Social Insurance Institution. Serum enterolactone concentration was significantly lower in those who had used oral antimicrobials up to 12–16 months before serum sampling than in nonusers (16.4 vs. 19.3 nmol/liter). The concentration was associated with the number of treatments and the time from the last treatment. Modest differences were present between various antimicrobials. The authors' findings support the crucial role of gut microflora in the metabolism of lignans. Furthermore, recent use of antimicrobials should be considered when the association between serum enterolactone concentration and risk of chronic diseases is studied.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>11867359</pmid><doi>10.1093/aje/155.5.472</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - blood Administration, Oral Adult Anti-Bacterial Agents - adverse effects Antibacterial agents antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents bacteria Biological and medical sciences biological markers Biomarkers - analysis BMI body mass index Chronic Disease confidence interval Cross-Sectional Studies Digestive System - microbiology drug therapy Female Humans intestines lignans Lignans - blood Medical sciences metabolism Middle Aged Pharmacology. Drug treatments Risk Factors standard deviation time-resolved fluoroimmunoassay TR-FIA |
| title | Use of Oral Antimicrobials Decreases Serum Enterolactone Concentration |
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