Molecular Epitope Determination of Aptamer Complexes of the Multidomain Protein C‐Met by Proteolytic Affinity‐Mass Spectrometry

C‐Met protein is a glycosylated receptor tyrosine kinase of the hepatocyte growth factor (HGF), composed of an α and a β chain. Upon ligand binding, C‐Met transmits intracellular signals by a unique multi‐substrate docking site. C‐Met can be aberrantly activated leading to tumorigenesis and other di...

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Veröffentlicht in:	ChemMedChem 2020-02, Vol.15 (4), p.363-369
Hauptverfasser:	Lupu, Loredana, Wiegand, Pascal, Hüttmann, Nico, Rawer, Stephan, Kleinekofort, Wolfgang, Shugureva, Irina, Kichkailo, Anna S., Tomilin, Felix N., Lazarev, Alexander, Berezovski, Maxim V., Przybylski, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity affinity-mass spectrometry aptamer epitopes aptamer-C-Met complexes Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - immunology Binding Biomarkers Biosensors C-Met protein Cancer Deoxyribonucleic acid Diagnostic systems DNA Dose-Response Relationship, Drug epitope peptide analysis Epitopes Epitopes - chemistry Epitopes - immunology Growth factors Hepatocyte growth factor Humans Kinases Ligands Mass Spectrometry Mass spectroscopy MET protein Molecular interactions Molecular Structure Peptides Peptides - chemistry Peptides - immunology Protein C Protein-tyrosine kinase receptors Proteins Proteolysis Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - immunology Scientific imaging SELEX Aptamer Technique Spectroscopy Structure-Activity Relationship Substrates tumor biomarkers Tumorigenesis Tyrosine
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