Pharmacokinetics and Pharmacodynamics of Dexamethasone Sodium-m-Sulfobenzoate (DS) after Intravenous and Intramuscular Administration: A Comparison with Dexamethasone Phosphate (DP)

The pharmacokinetics (PK) and pharmacodynamics (effects on blood lymphocytes) of dexamethasone (D) after intravenous (i.v.) administration of dexamethasone phosphate (DP, 10 mg, equivalent to 8.3 mg of dexamethasone) and after intravenous and intramuscular (i.m.) administration of dexamethasone sulf...

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Veröffentlicht in:	Journal of clinical pharmacology 2001-04, Vol.41 (4), p.425-434
Hauptverfasser:	Hochhaus, Günther, Barth, Jürgen, Al-Fayoumi, Suliman, Suarez, Sandra, Derendorf, Hartmut, Hochhaus, Renate, Möllmann, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cross-Over Studies Dexamethasone - administration & dosage Dexamethasone - adverse effects Dexamethasone - analogs & derivatives Dexamethasone - pharmacokinetics Flow Cytometry Glucocorticoids - therapeutic use Half-Life Humans Injections, Intramuscular Injections, Intravenous Lymphocytes - drug effects Lymphopenia - chemically induced Male Medical sciences Metabolic Clearance Rate Models, Biological Pharmacology. Drug treatments Radioimmunoassay
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