Single-Dose Gabapentin Pharmacokinetics and Safety in Healthy Infants and Children

Gabapentin (Neurontin®) is a gamma‐aminobutyric acid analogue indicated in adults for adjunctive treatment of partial seizures with or without secondary generalization. Two studies were conducted to determine the single‐dose pharmacokinetics of gabapentin in healthy subjects age 1 month to 12 years...

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Veröffentlicht in:	Journal of clinical pharmacology 2001-05, Vol.41 (5), p.507-514
Hauptverfasser:	Haig, George M., Bockbrader, Howard N., Wesche, David L., Boellner, Samuel W., Ouellet, Daniele, Brown, Richard R., Randinitis, Edward J., Posvar, Edward L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - administration & dosage Acetates - adverse effects Acetates - pharmacokinetics Administration, Oral Amines Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Anticonvulsants. Antiepileptics. Antiparkinson agents Area Under Curve Biological and medical sciences Child Child, Preschool Cyclohexanecarboxylic Acids Female Gabapentin gamma-Aminobutyric Acid Half-Life Humans Infant Male Medical sciences Metabolic Clearance Rate Neuropharmacology Pharmacology. Drug treatments Regression Analysis
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