P-glycoprotein Interactions of Nefazodone and Trazodone in Cell Culture

This study investigated the effects of nefazodone (NFZ) and trazodone (TZD) on P‐glycoprotein (P‐gp) activity and expression in cell culture. NFZ and TZD showed no differential transport between the basolateral to apical and apical to basolateral direction across Caco‐2 cell monolayers. Transport in...

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Veröffentlicht in:	Journal of clinical pharmacology 2001-07, Vol.41 (7), p.708-714
Hauptverfasser:	Störmer, Elke, von Moltke, Lisa L., Perloff, Michael D., Greenblatt, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents, Second-Generation - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Biological and medical sciences Biological Transport - drug effects Caco-2 Cells Calcium Channel Blockers - pharmacology Chromatography, High Pressure Liquid Drug Interactions Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Piperazines Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Trazodone - pharmacology Triazoles - pharmacology Verapamil - pharmacology
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