The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region

Conformational conversion of the cellular isoform of prion protein, designated PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , is an essential pathogenic event in prion diseases. However, the exact conversion mechanism remains largely unknown. Lines of evidence indicate that the...

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Veröffentlicht in:	Molecular neurobiology 2020-02, Vol.57 (2), p.1203-1216
Hauptverfasser:	Das, Nandita Rani, Miyata, Hironori, Hara, Hideyuki, Chida, Junji, Uchiyama, Keiji, Masujin, Kentaro, Watanabe, Hitomi, Kondoh, Gen, Sakaguchi, Suehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloidogenesis Biomedical and Life Sciences Biomedicine Cell Biology Clonal deletion Codons Lysine Neurobiology Neurology Neurosciences Pathogenesis Prion protein Prions Transgenic mice
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