UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

Background: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of G2 arrest sensitizes cells to the effects of DNA-damaging agents. UCN-01 (7-hydroxystaurosporine), a protein kinase C...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1996-07, Vol.88 (14), p.956-965
Hauptverfasser:	Wang, Qizhi, Fan, Saijun, Eastman, Alan, Worland, Peter J., Sausville, Edward A., O'Connor, Patrick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Burkitt Lymphoma - drug therapy Cancer CDC2 Protein Kinase - drug effects CDC2 Protein Kinase - radiation effects Cell Division - drug effects Cell Division - genetics Cell Division - radiation effects Cell Survival - drug effects Cell Survival - radiation effects Cellular biology Cisplatin - pharmacology Colonic Neoplasms - drug therapy Cyclin B Cyclin B1 Cyclins - drug effects Cyclins - radiation effects Drug Synergism Flow Cytometry G2 Phase - drug effects G2 Phase - radiation effects Gamma Rays General aspects Genes, p53 - genetics Genetics Humans Immunoblotting Medical sciences Mitotic Index Mutation Pharmacology. Drug treatments Precipitin Tests Radiation Dosage Staurosporine - analogs & derivatives Tumor Cells, Cultured
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