Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin
[Display omitted] •Impedimetric sensitivity was improved by enlarging electroactive surface area.•Electroactive surface area was tuned by varying inter-sheet distance between rGOs.•Detection limit of electrochemical myoglobin-sensors was 2.37 pM.•High selectivity for myoglobin detection over other h...
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| creator | Yoo, Seong Soo Kim, So Young Kim, Kwang Su Hong, Sunghwan Oh, Min Jun Nam, Myeong Gyun Kim, Woo-Jae Park, Juhyun Chung, Chan-Hwa Choe, Woo-Seok Yoo, Pil J. |
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•Impedimetric sensitivity was improved by enlarging electroactive surface area.•Electroactive surface area was tuned by varying inter-sheet distance between rGOs.•Detection limit of electrochemical myoglobin-sensors was 2.37 pM.•High selectivity for myoglobin detection over other heme groups was confirmed.
In order to improve the sensitivity of electrochemical impedance spectroscopy (EIS)-based biosensors, a number of structuring strategies to promote enlarging the electroactive surface area have been recently proposed. However, these approaches have not been applicable to graphene-based electrodes especially due to their ultrathin film thickness (usually |
| doi_str_mv | 10.1016/j.snb.2019.127477 |
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•Impedimetric sensitivity was improved by enlarging electroactive surface area.•Electroactive surface area was tuned by varying inter-sheet distance between rGOs.•Detection limit of electrochemical myoglobin-sensors was 2.37 pM.•High selectivity for myoglobin detection over other heme groups was confirmed.
In order to improve the sensitivity of electrochemical impedance spectroscopy (EIS)-based biosensors, a number of structuring strategies to promote enlarging the electroactive surface area have been recently proposed. However, these approaches have not been applicable to graphene-based electrodes especially due to their ultrathin film thickness (usually <10 nm) and incompatibility with top-down based structuring methods. To challenge this limitation, in this work, we presented a novel means to increase the electroactive surface area and the sensitivity of graphene electrode-based EIS biosensors with obviation of any extrinsic structuring method, such as patterning or pore generation. Instead, graphene oxide (GO) nanosheets functionalized with octadecylamine (ODA) groups to alter the inter-sheet spacing were synthesized and assembled to stacked films. Then, GO films were thermally reduced to form the roughened surface to maximize the electroactive surface area and sensing sensitivity. As a proof of concept demonstration, the sensing performances of rGO electrodes with differential inter-sheet distance were assessed via EIS measurements for the detection of myoglobin (Mb), a representative biomarker of acute myocardial infarction. Taken together, the deliberate control of the extent of interlayer alkylation of stacked GO nanosheets proved to be an effective strategy to produce rGO electrodes with significantly enhanced and/or controlled surface area, giving rise to a remarkably high sensing performance with the detection limit of 2.37 pM concentration of Mb. The presented strategy is simple yet powerful and widely applicable to various types of target molecules, it is therefore expected to provide general platform for biomedical and environmental sensors.</description><identifier>ISSN: 0925-4005</identifier><identifier>EISSN: 1873-3077</identifier><identifier>DOI: 10.1016/j.snb.2019.127477</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Alkylation ; Biomarkers ; Biosensors ; Control surfaces ; Detection ; Electrochemical impedance spectroscopy ; Electrodes ; Film thickness ; Graphene ; Graphene oxide ; Incompatibility ; Inter-sheet distance ; Interlayers ; Myocardial infarction ; Myoglobin ; Myoglobins ; Nanostructure ; Sensitivity ; Surface area ; Thin films</subject><ispartof>Sensors and actuators. B, Chemical, 2020-02, Vol.305, p.127477, Article 127477</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. Feb 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-70a4ea50c400344cec6fe7544343747a819273ce2cb5379a6f2537ea7fde63123</citedby><cites>FETCH-LOGICAL-c325t-70a4ea50c400344cec6fe7544343747a819273ce2cb5379a6f2537ea7fde63123</cites><orcidid>0000-0002-5499-6566 ; 0000-0003-2808-1001 ; 0000-0003-3444-3486</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.snb.2019.127477$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Yoo, Seong Soo</creatorcontrib><creatorcontrib>Kim, So Young</creatorcontrib><creatorcontrib>Kim, Kwang Su</creatorcontrib><creatorcontrib>Hong, Sunghwan</creatorcontrib><creatorcontrib>Oh, Min Jun</creatorcontrib><creatorcontrib>Nam, Myeong Gyun</creatorcontrib><creatorcontrib>Kim, Woo-Jae</creatorcontrib><creatorcontrib>Park, Juhyun</creatorcontrib><creatorcontrib>Chung, Chan-Hwa</creatorcontrib><creatorcontrib>Choe, Woo-Seok</creatorcontrib><creatorcontrib>Yoo, Pil J.</creatorcontrib><title>Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin</title><title>Sensors and actuators. B, Chemical</title><description>[Display omitted]
•Impedimetric sensitivity was improved by enlarging electroactive surface area.•Electroactive surface area was tuned by varying inter-sheet distance between rGOs.•Detection limit of electrochemical myoglobin-sensors was 2.37 pM.•High selectivity for myoglobin detection over other heme groups was confirmed.
In order to improve the sensitivity of electrochemical impedance spectroscopy (EIS)-based biosensors, a number of structuring strategies to promote enlarging the electroactive surface area have been recently proposed. However, these approaches have not been applicable to graphene-based electrodes especially due to their ultrathin film thickness (usually <10 nm) and incompatibility with top-down based structuring methods. To challenge this limitation, in this work, we presented a novel means to increase the electroactive surface area and the sensitivity of graphene electrode-based EIS biosensors with obviation of any extrinsic structuring method, such as patterning or pore generation. Instead, graphene oxide (GO) nanosheets functionalized with octadecylamine (ODA) groups to alter the inter-sheet spacing were synthesized and assembled to stacked films. Then, GO films were thermally reduced to form the roughened surface to maximize the electroactive surface area and sensing sensitivity. As a proof of concept demonstration, the sensing performances of rGO electrodes with differential inter-sheet distance were assessed via EIS measurements for the detection of myoglobin (Mb), a representative biomarker of acute myocardial infarction. Taken together, the deliberate control of the extent of interlayer alkylation of stacked GO nanosheets proved to be an effective strategy to produce rGO electrodes with significantly enhanced and/or controlled surface area, giving rise to a remarkably high sensing performance with the detection limit of 2.37 pM concentration of Mb. The presented strategy is simple yet powerful and widely applicable to various types of target molecules, it is therefore expected to provide general platform for biomedical and environmental sensors.</description><subject>Alkylation</subject><subject>Biomarkers</subject><subject>Biosensors</subject><subject>Control surfaces</subject><subject>Detection</subject><subject>Electrochemical impedance spectroscopy</subject><subject>Electrodes</subject><subject>Film thickness</subject><subject>Graphene</subject><subject>Graphene oxide</subject><subject>Incompatibility</subject><subject>Inter-sheet distance</subject><subject>Interlayers</subject><subject>Myocardial infarction</subject><subject>Myoglobin</subject><subject>Myoglobins</subject><subject>Nanostructure</subject><subject>Sensitivity</subject><subject>Surface area</subject><subject>Thin films</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKBDEQRYMoOD4-wF3AdY95dcfBlQy-QHCj65BJqqdr6E7GpEecf_CjjbS4dFVQdW9V3UPIBWdzznhztZnnsJoLxhdzLrTS-oDM-LWWlWRaH5IZW4i6UozVx-Qk5w1jTMmGzcjXMoYxxb7HsKYYRkhV7gDGymMebXBQmjSB3znwdJ3stoMANH6iBwo9uOL1kGkbE-1w3fV7miFkHPHjb-46GNDZnuKwBY8DjAndJCs3Y0uHfVz3cYXhjBy1ts9w_ltPydv93evysXp-eXha3j5XTop6rDSzCmzNXMkjlXLgmhZ0rZRUskS313whtHQg3KqWemGbVpQKVrceGsmFPCWX095tiu87yKPZxF0K5aQRsm605lLpouKTyqWYc4LWbBMONu0NZ-YHutmYAt38QDcT9OK5mTxQ3v9ASCY7hILRYyowjI_4j_sb_GKNOw</recordid><startdate>20200215</startdate><enddate>20200215</enddate><creator>Yoo, Seong Soo</creator><creator>Kim, So Young</creator><creator>Kim, Kwang Su</creator><creator>Hong, Sunghwan</creator><creator>Oh, Min Jun</creator><creator>Nam, Myeong Gyun</creator><creator>Kim, Woo-Jae</creator><creator>Park, Juhyun</creator><creator>Chung, Chan-Hwa</creator><creator>Choe, Woo-Seok</creator><creator>Yoo, Pil J.</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-5499-6566</orcidid><orcidid>https://orcid.org/0000-0003-2808-1001</orcidid><orcidid>https://orcid.org/0000-0003-3444-3486</orcidid></search><sort><creationdate>20200215</creationdate><title>Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin</title><author>Yoo, Seong Soo ; Kim, So Young ; Kim, Kwang Su ; Hong, Sunghwan ; Oh, Min Jun ; Nam, Myeong Gyun ; Kim, Woo-Jae ; Park, Juhyun ; Chung, Chan-Hwa ; Choe, Woo-Seok ; Yoo, Pil J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-70a4ea50c400344cec6fe7544343747a819273ce2cb5379a6f2537ea7fde63123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alkylation</topic><topic>Biomarkers</topic><topic>Biosensors</topic><topic>Control surfaces</topic><topic>Detection</topic><topic>Electrochemical impedance spectroscopy</topic><topic>Electrodes</topic><topic>Film thickness</topic><topic>Graphene</topic><topic>Graphene oxide</topic><topic>Incompatibility</topic><topic>Inter-sheet distance</topic><topic>Interlayers</topic><topic>Myocardial infarction</topic><topic>Myoglobin</topic><topic>Myoglobins</topic><topic>Nanostructure</topic><topic>Sensitivity</topic><topic>Surface area</topic><topic>Thin films</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Seong Soo</creatorcontrib><creatorcontrib>Kim, So Young</creatorcontrib><creatorcontrib>Kim, Kwang Su</creatorcontrib><creatorcontrib>Hong, Sunghwan</creatorcontrib><creatorcontrib>Oh, Min Jun</creatorcontrib><creatorcontrib>Nam, Myeong Gyun</creatorcontrib><creatorcontrib>Kim, Woo-Jae</creatorcontrib><creatorcontrib>Park, Juhyun</creatorcontrib><creatorcontrib>Chung, Chan-Hwa</creatorcontrib><creatorcontrib>Choe, Woo-Seok</creatorcontrib><creatorcontrib>Yoo, Pil J.</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Seong Soo</au><au>Kim, So Young</au><au>Kim, Kwang Su</au><au>Hong, Sunghwan</au><au>Oh, Min Jun</au><au>Nam, Myeong Gyun</au><au>Kim, Woo-Jae</au><au>Park, Juhyun</au><au>Chung, Chan-Hwa</au><au>Choe, Woo-Seok</au><au>Yoo, Pil J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2020-02-15</date><risdate>2020</risdate><volume>305</volume><spage>127477</spage><pages>127477-</pages><artnum>127477</artnum><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>[Display omitted]
•Impedimetric sensitivity was improved by enlarging electroactive surface area.•Electroactive surface area was tuned by varying inter-sheet distance between rGOs.•Detection limit of electrochemical myoglobin-sensors was 2.37 pM.•High selectivity for myoglobin detection over other heme groups was confirmed.
In order to improve the sensitivity of electrochemical impedance spectroscopy (EIS)-based biosensors, a number of structuring strategies to promote enlarging the electroactive surface area have been recently proposed. However, these approaches have not been applicable to graphene-based electrodes especially due to their ultrathin film thickness (usually <10 nm) and incompatibility with top-down based structuring methods. To challenge this limitation, in this work, we presented a novel means to increase the electroactive surface area and the sensitivity of graphene electrode-based EIS biosensors with obviation of any extrinsic structuring method, such as patterning or pore generation. Instead, graphene oxide (GO) nanosheets functionalized with octadecylamine (ODA) groups to alter the inter-sheet spacing were synthesized and assembled to stacked films. Then, GO films were thermally reduced to form the roughened surface to maximize the electroactive surface area and sensing sensitivity. As a proof of concept demonstration, the sensing performances of rGO electrodes with differential inter-sheet distance were assessed via EIS measurements for the detection of myoglobin (Mb), a representative biomarker of acute myocardial infarction. Taken together, the deliberate control of the extent of interlayer alkylation of stacked GO nanosheets proved to be an effective strategy to produce rGO electrodes with significantly enhanced and/or controlled surface area, giving rise to a remarkably high sensing performance with the detection limit of 2.37 pM concentration of Mb. The presented strategy is simple yet powerful and widely applicable to various types of target molecules, it is therefore expected to provide general platform for biomedical and environmental sensors.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2019.127477</doi><orcidid>https://orcid.org/0000-0002-5499-6566</orcidid><orcidid>https://orcid.org/0000-0003-2808-1001</orcidid><orcidid>https://orcid.org/0000-0003-3444-3486</orcidid></addata></record> |
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| subjects | Alkylation Biomarkers Biosensors Control surfaces Detection Electrochemical impedance spectroscopy Electrodes Film thickness Graphene Graphene oxide Incompatibility Inter-sheet distance Interlayers Myocardial infarction Myoglobin Myoglobins Nanostructure Sensitivity Surface area Thin films |
| title | Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin |
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