Randomized Phase I Chemoprevention Dose-Seeking Study of α-Difluoromethylornithine

Background: α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), the key enzyme in mammalian polyamine biosynthesis. Levels of ODC are closely related to tumor promotion, and inhibition of ODC is associated with suppression of tumor development in laborator...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1993-05, Vol.85 (9), p.732-737
Hauptverfasser:	Love, Richard R., Carbone, Paul P., Verma, Ajit K., Gilmore, Debra, Carey, Patrick, Tutsch, Kendra D., Pomplun, Marcia, Wilding, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic agents Biological and medical sciences Carcinoma - drug therapy Colonic Neoplasms - drug therapy Eflornithine - pharmacokinetics Eflornithine - therapeutic use Enzyme Induction - drug effects Enzymes Female General aspects Humans Male Medical research Medical sciences Ornithine Decarboxylase - metabolism Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Skin - enzymology Tetradecanoylphorbol Acetate - pharmacology Tumors Urinary Bladder Neoplasms - drug therapy
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