Radiotherapy-Related Lung Fibrosis Enhanced by Tamoxifen

Background: Tamoxifen is an antiestrogen with proven efficacy and low toxicity in the treatment of breast cancer. However, tamoxifen has been shown to exert a number of nonhor-monalas well as hormonal effects. One nonhormonal effect of tamoxifen is the induction of transforming growth factor-β (TGF-...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1996-07, Vol.88 (13), p.918-922
Hauptverfasser:	Bentzen, Søren M., Skoczylas, Jerzy Z., Overgaard, Marie, Overgaard, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - radiotherapy Chemotherapy, Adjuvant - adverse effects Female Genital system. Mammary gland Humans Lung cancer Mastectomy Medical sciences Middle Aged Pharmaceuticals Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - etiology Pulmonary Fibrosis - metabolism Radiology Radiotherapy Dosage Radiotherapy, Adjuvant - adverse effects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tamoxifen - adverse effects Tamoxifen - therapeutic use Transforming Growth Factor beta - metabolism
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