Constitutive Variability in the Pharmacokinetics of the Natural Retinoid, All-trans-Retinoic Acid, and Its Modulation by Ketoconazole

Background All-trans-retinoic acid (all-trans RA) induces complete remission in most patients with acute promyelocytic leukemia (APL). However, continuous oral dosing results in progressive decline in plasma drug concentrations, which is associated with relapse and resistance to this retinoid. We sp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1993-12, Vol.85 (23), p.1921-1926
Hauptverfasser:	Rigas, James R., Francis, Prudence A., Muindi, Josephia R. F., Kris, Mark G., Huselton, Christine, DeGrazia, Francis, Orazem, John P., Young, Charles W., Warrell, Raymond P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cancer Carcinoma, Non-Small-Cell Lung - metabolism Chemotherapy Cytochrome P-450 Enzyme Inhibitors Dose-Response Relationship, Drug Drug Interactions Drug therapy Drug Tolerance Humans Ketoconazole - pharmacology Leukemia, Promyelocytic, Acute - metabolism Lung Neoplasms - metabolism Medical research Medical sciences Neoplasms - enzymology Neoplasms - metabolism Pharmacology Pharmacology. Drug treatments Tretinoin - administration & dosage Tretinoin - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!