The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling

Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties in various brain disord...

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Veröffentlicht in:	Journal of molecular neuroscience 2020-03, Vol.70 (3), p.422-432
Hauptverfasser:	Du, Jing-Jing, Liu, Zhi-Qin, Yan, Yue, Xiong, Jing, Jia, Xiao-Tao, Di, Zheng-Li, Ren, Jing-Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Benzoxazines - pharmacology Benzoxazines - therapeutic use Biomedical and Life Sciences Biomedicine Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoids - pharmacology Cannabinoids - therapeutic use Carbon monoxide Carbon monoxide poisoning Carbon Monoxide Poisoning - drug therapy Cell Biology Chemical compounds Cognition Cognitive ability Complications Cytokines Hippocampus Inhalation Interleukin-1 Receptor-Like 1 Protein - metabolism Interleukin-33 - genetics Interleukin-33 - metabolism Lectins, C-Type - genetics Lectins, C-Type - metabolism Male Mannose-Binding Lectins - genetics Mannose-Binding Lectins - metabolism Microglia Microglia - drug effects Microglia - metabolism Morpholines - pharmacology Morpholines - therapeutic use Naphthalenes - pharmacology Naphthalenes - therapeutic use Neurochemistry Neurological complications Neurology Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Pharmacology Phenotypes Poisoning Polarization Protein expression Proteins Proteomics Rats Rats, Sprague-Dawley Receptor mechanisms Receptors Receptors, Cannabinoid - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Signal Transduction Signaling
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