Functional phenotype variations of two novel KV7.1 mutations identified in patients with Long QT syndrome

Background The slow delayed rectifier potassium current IKs is crucial for the repolarization of the cardiac action potential. It is conducted by the voltage‐gated channel KV7.1 encoded by KCNQ1, together with its β‐subunit KCNE1. Loss‐of‐function (LOF) mutations in KCNQ1 have been associated with h...

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